Results 111 to 120 of about 29,397,810 (306)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Building Interdisciplinary Partnerships for Community-Engaged Environmental Health Research in Appalachian Virginia

, 2020
This article describes a collaboration among a group of university faculty, undergraduate students, local governments, local residents, and U.S. Army staff to address long-standing concerns about the environmental health effects of an Army ammunition ...
Lauren Buttling, Satterwhite, Emily M., Emily Satterwhite, Prussin, Aaron J. II, Christopher K. Thompson, Gohlke, Julia M., Shannon Elizabeth Bell, Aaron J. Prussin, Buttling, Lauren G., Julia M. Gohlke, Pan, Jin, Thompson, Christopher K., Bell, Shannon E., Linsey C. Marr, Marr, Linsey C., Jin Pan   +15 more
core   +1 more source

Occupational Exposure to Volatile Organic Compounds in Polyurethane Foam Production—Concentration, Variability and Health Risk Assessment

Molecules
Volatile organic compounds (VOCs) are a major occupational concern in polyurethane foam production, where exposure may impact worker health. This study identified key VOCs and evaluated their concentrations across different sections of a polyurethane ...
Andrzej R. Reindl, Ewa Olkowska, Jakub Pawłowski, Lidia Wolska   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

CDC's Division of Environmental Health Science and Practice [PDF]

CDC\u2019s Division of Environmental Health Science and Practice (DEHSP) works to protect the health and quality of life of all people in the United States.

core  

Carcinogenic contaminants in groundwater in the Ebocha and Mgbede oil fields of Southern Nigeria

RUDN Journal of Ecology and Life Safety
In accordance with the purpose and objectives of this study, standard methods were applied with the aim and objectives of this study, standard methods were applied in evaluating groundwater contamination from an oil waste pit in the Mgbede and Ebocha Oil
Mazico Henry Ikwulemenze, Ifeanyichukwu Clinton Ezekwe, Enos Ihediohamma Emereibeole, Leonard Udochi Mgbeahuruike, Joseph Ikechukwu Nwachukwu   +4 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Addressing Environmental Health Problems in Ogoniland through Implementation of United Nations Environment Program Recommendations: Environmental Management Strategies

, 2017
On 4 August 2011, United Nations Environment Program (UNEP) submitted an unprecedented, scientific, groundbreaking environmental assessment report (EAR) on Ogoniland to the Nigerian government.
O. H. Yakubu
semanticscholar   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source