Current Strategies for Real-Time Enzyme Activation [PDF]
Biomolecules, 2022 Enzyme activation is a powerful means of achieving biotransformation function, aiming to intensify the reaction processes with a higher yield of product in a short time, and can be exploited for diverse applications.
Fang Wang +3 more
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Biophysical characterization of hit compounds for mechanism-based enzyme activation. [PDF]
PLoS ONE, 2018 Across all families of enzymes, only a dozen or so distinct classes of non-natural small molecule activators have been characterized, with only four known modes of activation among them.
Xiangying Guan +3 more
doaj +3 more sources
Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation. [PDF]
Nat Struct Mol Biol, 2020 DUOX1, an NADPH oxidase family member, catalyzes the production of hydrogen peroxide. DUOX1 is expressed in various tissues, including the thyroid and respiratory tract, and plays a crucial role in processes such as thyroid hormone biosynthesis and ...
Sun J.
europepmc +2 more sources
Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems. [PDF]
Nat Commun, 2020 Non-enzymatic proteins including antibodies function as biomarkers and are used as biopharmaceuticals in several diseases. Protein-responsive soft materials capable of the controlled release of drugs and proteins have potential for use in next-generation
Shigemitsu H +7 more
europepmc +2 more sources
Enzyme activation through the utilization of intrinsic dianion binding energy. [PDF]
Protein Eng Des Sel, 2017 43 We consider 'the proposition that the intrinsic binding energy that results from the noncovalent interaction of a specific substrate with the active site of the enzyme is considerably larger than is generally believed.
Amyes TL +4 more
europepmc +2 more sources
Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog. [PDF]
Elife, 2016 Catalytically inactive enzyme paralogs occur in many genomes. Some regulate their active counterparts but the structural principles of this regulation remain largely unknown.
Volkov OA +8 more
europepmc +2 more sources
Protein Stabilization and Enzyme Activation in Ionic Liquids: Specific Ion Effects. [PDF]
J Chem Technol Biotechnol, 2016 There are still debates on whether the hydration of ions perturbs the water structure, and what is the degree of such disturbance; therefore, the origin of Hofmeister effect on protein stabilization continues being questioned.
Zhao H.
europepmc +2 more sources
Enzyme localization can drastically affect signal amplification in signal transduction pathways [PDF]
, 2007 Push-pull networks are ubiquitous in signal transduction pathways in both prokaryotic and eukaryotic cells. They allow cells to strongly amplify signals via the mechanism of zero-order ultrasensitivity. In a push-pull network, two antagonistic enzymes control the activity of a protein by covalent modification.
van Albada, Siebe B. +1 more
arxiv +6 more sources
Enzyme-Activation by Antibody [PDF]
The Journal of Immunology, 1971 Abstract Antisera to bovine pancreatic ribonuclease were fractionated on columns of DEAE Sephadex A-50 and the fractions were characterized by allotype content, electrophoretic mobility, the heterogeneity of heavy chains and the effect on enzyme activity.
B. Cinader +2 more
openalex +2 more sources
Ibrutinib-induced pulmonary angiotensin-converting enzyme activation promotes atrial fibrillation in rats [PDF]
iScienceSummary: The molecular mechanism of ibrutinib-induced atrial fibrillation (AF) remains unclear. We here demonstrate that treating rats with ibrutinib for 4 weeks resulted in the development of inducible AF, left atrial enlargement, atrial fibrosis, and ...
Sen Yan +13 more
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