Results 1 to 10 of about 1,019,177 (144)

Current Strategies for Real-Time Enzyme Activation [PDF]

Biomolecules, 2022
Enzyme activation is a powerful means of achieving biotransformation function, aiming to intensify the reaction processes with a higher yield of product in a short time, and can be exploited for diverse applications.
Fang Wang, Yuchen Liu, Chang Du, Renjun Gao   +3 more
doaj   +2 more sources

Biophysical characterization of hit compounds for mechanism-based enzyme activation. [PDF]

PLoS ONE, 2018
Across all families of enzymes, only a dozen or so distinct classes of non-natural small molecule activators have been characterized, with only four known modes of activation among them.
Xiangying Guan, Alok Upadhyay, Sudipto Munshi, Raj Chakrabarti   +3 more
doaj   +2 more sources

An enzyme activation network reveals extensive regulatory crosstalk between metabolic pathways [PDF]

Molecular Systems Biology
Enzyme activation by cellular metabolites plays a pivotal role in regulating metabolic processes. Nevertheless, our comprehension of such activation events on a global network scale remains incomplete.
Sultana Mohammed Al Zubaidi, Muhammad Ibtisam Nasar, Richard A Notebaart, Markus Ralser, Mohammad Tauqeer Alam   +4 more
doaj   +2 more sources

Ibrutinib-induced pulmonary angiotensin-converting enzyme activation promotes atrial fibrillation in rats [PDF]

iScience
Summary: The molecular mechanism of ibrutinib-induced atrial fibrillation (AF) remains unclear. We here demonstrate that treating rats with ibrutinib for 4 weeks resulted in the development of inducible AF, left atrial enlargement, atrial fibrosis, and ...
Sen Yan, Wei Xu, Ning Fang, Luyifei Li, Ning Yang, Xinbo Zhao, Hongting Hao, Yun Zhang, Qian Liang, Zhiqi Wang, Yu Duan, Song Zhang, Yongtai Gong, Yue Li   +13 more
doaj   +2 more sources

“Water-like” Dual-Functionalized Ionic Liquids for Enzyme Activation [PDF]

ACS Omega, 2019
Hua Zhao, Glenn A. Harter, Caden J. Martin   +2 more
doaj   +2 more sources

High selectivity of the hyperthermophilic subtilase propeptide domain toward inhibition of its cognate protease

Microbiology Spectrum, 2023
Microbial extracellular subtilases are highly active proteolytic enzymes commonly used in commercial applications. These subtilases are synthesized in their inactive proform, which matures into the active protease under the control of the propeptide ...
Miha Bahun, Nataša Poklar Ulrih
doaj   +1 more source

Differentiated modulation of signaling molecules AMPK and SIRT1 in experimentally drug-induced hepatocyte injury

Biomedical Papers, 2023
Aim. Currently available medicines have little to offer in terms of supporting the regeneration of injured hepatic cells. Previous experimental studies have shown that resveratrol and metformin, less specific activators of AMP-activated protein kinase ...
Lea Njeka Wojnarova, Nikolina Kutinova Canova, Mahak Arora, Hassan Farghali   +3 more
doaj   +1 more source

Strigolactones Modulate Cellular Antioxidant Defense Mechanisms to Mitigate Arsenate Toxicity in Rice Shoots

Antioxidants, 2021
Metalloid contamination, such as arsenic poisoning, poses a significant environmental problem, reducing plant productivity and putting human health at risk. Phytohormones are known to regulate arsenic stress; however, the function of strigolactones (SLs)
Mohammad Golam Mostofa, Chien Van Ha, Md. Mezanur Rahman, Kien Huu Nguyen, Sanjida Sultana Keya, Yasuko Watanabe, Misao Itouga, Abeer Hashem, Elsayed Fathi Abd_Allah, Masayuki Fujita, Lam-Son Phan Tran   +10 more
doaj   +1 more source

A Novel Method of a High Pressure Processing Pre-Treatment on the Juice Yield and Quality of Persimmon

Foods, 2021
This study investigates the effects of a high pressure processing pre-treatment (pre-HPP) on the juice yield of persimmon (Diospyros kaki L.) pulp and the pre-HPP plus HPP or thermal processing (TP) on microorganism inactivation and quality changes of ...
Jiayue Xu, Yilun Wang, Xinyue Zhang, Zhen Zhao, Yao Yang, Xin Yang, Yongtao Wang, Xiaojun Liao, Liang Zhao   +8 more
doaj   +1 more source

Conditionally Activated (“Caged”) Oligonucleotides

Molecules, 2021
Conditionally activated (“caged”) oligonucleotides provide useful spatiotemporal control for studying dynamic biological processes, e.g., regulating in vivo gene expression or probing specific oligonucleotide targets.
Linlin Yang, Ivan J. Dmochowski
doaj   +1 more source