Current Strategies for Real-Time Enzyme Activation [PDF]
Biomolecules, 2022 Enzyme activation is a powerful means of achieving biotransformation function, aiming to intensify the reaction processes with a higher yield of product in a short time, and can be exploited for diverse applications.
Fang Wang +3 more
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Biophysical characterization of hit compounds for mechanism-based enzyme activation. [PDF]
PLoS ONE, 2018 Across all families of enzymes, only a dozen or so distinct classes of non-natural small molecule activators have been characterized, with only four known modes of activation among them.
Xiangying Guan +3 more
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Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation. [PDF]
Nat Struct Mol Biol, 2020 DUOX1, an NADPH oxidase family member, catalyzes the production of hydrogen peroxide. DUOX1 is expressed in various tissues, including the thyroid and respiratory tract, and plays a crucial role in processes such as thyroid hormone biosynthesis and ...
Sun J.
europepmc +2 more sources
Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems. [PDF]
Nat Commun, 2020 Non-enzymatic proteins including antibodies function as biomarkers and are used as biopharmaceuticals in several diseases. Protein-responsive soft materials capable of the controlled release of drugs and proteins have potential for use in next-generation
Shigemitsu H +7 more
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Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog. [PDF]
Elife, 2016 Catalytically inactive enzyme paralogs occur in many genomes. Some regulate their active counterparts but the structural principles of this regulation remain largely unknown.
Volkov OA +8 more
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P2X7 Receptor Induces Tumor Necrosis Factor-α Converting Enzyme Activation and Release to Boost TNF-α Production. [PDF]
Front Immunol, 2017 Tumor necrosis factor (TNF)-α is a major pro-inflammatory cytokine produced in response to toll-like receptor stimulation. TNF-α release is controlled by the activity of TNF-α converting enzyme (TACE) that cut membrane-bound TNF-α to shed its ectodomain ...
Barberà-Cremades M +6 more
europepmc +2 more sources
An enzyme activation network reveals extensive regulatory crosstalk between metabolic pathways [PDF]
Molecular Systems BiologyEnzyme activation by cellular metabolites plays a pivotal role in regulating metabolic processes. Nevertheless, our comprehension of such activation events on a global network scale remains incomplete.
Sultana Mohammed Al Zubaidi +4 more
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Ibrutinib-induced pulmonary angiotensin-converting enzyme activation promotes atrial fibrillation in rats [PDF]
iScienceSummary: The molecular mechanism of ibrutinib-induced atrial fibrillation (AF) remains unclear. We here demonstrate that treating rats with ibrutinib for 4 weeks resulted in the development of inducible AF, left atrial enlargement, atrial fibrosis, and ...
Sen Yan +13 more
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Molecular Mechanisms of Enzyme Activation by Monovalent Cations. [PDF]
J Biol Chem, 2016 Gohara DW, Di Cera E.
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Enzyme activation through the utilization of intrinsic dianion binding energy. [PDF]
Protein Eng Des Sel, 2017 Amyes TL +4 more
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