Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation. [PDF]
Nat Struct Mol Biol, 2020 DUOX1, an NADPH oxidase family member, catalyzes the production of hydrogen peroxide. DUOX1 is expressed in various tissues, including the thyroid and respiratory tract, and plays a crucial role in processes such as thyroid hormone biosynthesis and ...
Sun J.
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Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems. [PDF]
Nat Commun, 2020 Non-enzymatic proteins including antibodies function as biomarkers and are used as biopharmaceuticals in several diseases. Protein-responsive soft materials capable of the controlled release of drugs and proteins have potential for use in next-generation
Shigemitsu H +7 more
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Molecular Mechanisms of Enzyme Activation by Monovalent Cations. [PDF]
J Biol Chem, 2016 Gohara DW, Di Cera E.
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Enzyme activation through the utilization of intrinsic dianion binding energy. [PDF]
Protein Eng Des Sel, 2017 43 We consider 'the proposition that the intrinsic binding energy that results from the noncovalent interaction of a specific substrate with the active site of the enzyme is considerably larger than is generally believed.
Amyes TL +4 more
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Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog. [PDF]
Elife, 2016 Catalytically inactive enzyme paralogs occur in many genomes. Some regulate their active counterparts but the structural principles of this regulation remain largely unknown.
Volkov OA +8 more
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Protein Stabilization and Enzyme Activation in Ionic Liquids: Specific Ion Effects. [PDF]
J Chem Technol Biotechnol, 2016 There are still debates on whether the hydration of ions perturbs the water structure, and what is the degree of such disturbance; therefore, the origin of Hofmeister effect on protein stabilization continues being questioned.
Zhao H.
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Mathematical modelling of OAS2 activation by dsRNA and effects of dsRNA lengths
AIMS Mathematics, 2021 The activation of 2'-5'-oligoadenylate synthetase (OAS) enzymes by direct interaction with viral double-stranded RNA (dsRNA) is a key part of the innate immune response to viral infection.
Deokro Lee +4 more
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Conditionally Activated (“Caged”) Oligonucleotides
Molecules, 2021 Conditionally activated (“caged”) oligonucleotides provide useful spatiotemporal control for studying dynamic biological processes, e.g., regulating in vivo gene expression or probing specific oligonucleotide targets.
Linlin Yang, Ivan J. Dmochowski
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Cyclic nucleotide specificity of the activator and catalytic sites of a cGMP-stimulated cGMP phosphodiesterase from Dictyostelium discoideum [PDF]
, 1985 The cellular slime mold Dictyostelium discoideum has an intracellular phosphodiesterase which specifically hydrolyzes cGMP. The enzyme is activated by low cGMP concentrations, and is involved in the reduction of chemoattractant-mediated elevations of ...
Baraniak, Janina, +8 more
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Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation
Frontiers in Immunology, 2019 5-lipoxygenase (5-LOX) is a non-heme iron-containing dioxygenase expressed in immune cells that catalyzes the two initial steps in the biosynthesis of leukotrienes.
Beatrice Dufrusine +13 more
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