Results 11 to 20 of about 1,019,197 (164)
A perspective on the discovery of enzyme activators
SLAS Discovery, 2022 Enzyme activation remains a largely under-represented and poorly exploited area of drug discovery despite some key literature examples of the successful application of enzyme activators by various mechanisms and their importance in a wide range of ...
Antonia Turberville +4 more
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Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation
Frontiers in Immunology, 2019 5-lipoxygenase (5-LOX) is a non-heme iron-containing dioxygenase expressed in immune cells that catalyzes the two initial steps in the biosynthesis of leukotrienes.
Beatrice Dufrusine +13 more
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Scientific Reports, 2023 The assembly state of enzymes is gaining interest as a mechanism for regulating the function of enzymes in living cells. One of the current topics in enzymology is the relationship between enzyme activity and the assembly state due to liquid–liquid phase
Tomoto Ura +7 more
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Scanning Electron Microscopic Study of the Tongue Papillae Formation
Central Asian Journal of Medical Sciences, 2017 Objectives: To clarify the morphology of the tongue papillae formation and the metabolic characteristics along the papillae distribution in rats. Methods: The experiment was designed as a cross-sectional study and included; a scanning electron and light ...
Shine-Od Dalkhsuren +2 more
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Activation of oxidoreductases by the formation of enzyme assembly
Scientific Reports, 2023 Biological properties of protein molecules depend on their interaction with other molecules, and enzymes are no exception. Enzyme activities are controlled by their interaction with other molecules in living cells.
Tomoto Ura +6 more
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Computational and Structural Biotechnology Journal, 2021 AMP-activated protein kinase (AMPK) is a key energy sensor regulating the cell metabolism in response to energy supply and demand. The evolutionary adaptation of AMPK to different tissues is accomplished through the expression of distinct isoforms that ...
Elnaz Aledavood +3 more
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The structural basis of the multi-step allosteric activation of Aurora B kinase
eLife, 2023 Aurora B, together with IN-box, the C-terminal part of INCENP, forms an enzymatic complex that ensures faithful cell division. The [Aurora B/IN-box] complex is activated by autophosphorylation in the Aurora B activation loop and in IN-box, but it is not ...
Dario Segura-Peña +8 more
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, 2019 Citation: 'enzyme activator' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.E02153 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +2 more sources
mBio, 2019 Carboxyl (C)-terminal processing proteases (CTPs) participate in protective and regulatory proteolysis in bacteria. The PDZ domain is central to the activity of CTPs but plays inherently different regulatory roles.
Chuang-Kai Chueh +5 more
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Enzyme-mediated hydrolytic activation of prodrugs
Acta Pharmaceutica Sinica B, 2011 Prodrug design is an important part of drug discovery. Prodrugs can offer many advantages over parent drugs such as increased solubility, enhanced stability, improved bioavailability, reduced side effects, and better selectivity.
Yan-hui Yang +4 more
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