Results 11 to 20 of about 6,536,634 (394)

ACTIVATION OF ENZYMES

open access: hybridJournal of Biological Chemistry, 1938
Leslie Hellerman, Christiane Stock
  +5 more sources

High selectivity of the hyperthermophilic subtilase propeptide domain toward inhibition of its cognate protease

open access: yesMicrobiology Spectrum, 2023
Microbial extracellular subtilases are highly active proteolytic enzymes commonly used in commercial applications. These subtilases are synthesized in their inactive proform, which matures into the active protease under the control of the propeptide ...
Miha Bahun, Nataša Poklar Ulrih
doaj   +1 more source

Differentiated modulation of signaling molecules AMPK and SIRT1 in experimentally drug-induced hepatocyte injury

open access: yesBiomedical Papers, 2023
Aim. Currently available medicines have little to offer in terms of supporting the regeneration of injured hepatic cells. Previous experimental studies have shown that resveratrol and metformin, less specific activators of AMP-activated protein kinase ...
Lea Njeka Wojnarova   +3 more
doaj   +1 more source

Strigolactones Modulate Cellular Antioxidant Defense Mechanisms to Mitigate Arsenate Toxicity in Rice Shoots

open access: yesAntioxidants, 2021
Metalloid contamination, such as arsenic poisoning, poses a significant environmental problem, reducing plant productivity and putting human health at risk. Phytohormones are known to regulate arsenic stress; however, the function of strigolactones (SLs)
Mohammad Golam Mostofa   +10 more
doaj   +1 more source

A Novel Method of a High Pressure Processing Pre-Treatment on the Juice Yield and Quality of Persimmon

open access: yesFoods, 2021
This study investigates the effects of a high pressure processing pre-treatment (pre-HPP) on the juice yield of persimmon (Diospyros kaki L.) pulp and the pre-HPP plus HPP or thermal processing (TP) on microorganism inactivation and quality changes of ...
Jiayue Xu   +8 more
doaj   +1 more source

Mathematical modelling of OAS2 activation by dsRNA and effects of dsRNA lengths

open access: yesAIMS Mathematics, 2021
The activation of 2'-5'-oligoadenylate synthetase (OAS) enzymes by direct interaction with viral double-stranded RNA (dsRNA) is a key part of the innate immune response to viral infection.
Deokro Lee   +4 more
doaj   +1 more source

Conditionally Activated (“Caged”) Oligonucleotides

open access: yesMolecules, 2021
Conditionally activated (“caged”) oligonucleotides provide useful spatiotemporal control for studying dynamic biological processes, e.g., regulating in vivo gene expression or probing specific oligonucleotide targets.
Linlin Yang, Ivan J. Dmochowski
doaj   +1 more source

A perspective on the discovery of enzyme activators

open access: yesSLAS Discovery, 2022
Enzyme activation remains a largely under-represented and poorly exploited area of drug discovery despite some key literature examples of the successful application of enzyme activators by various mechanisms and their importance in a wide range of ...
Antonia Turberville   +4 more
doaj   +1 more source

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