Cyclic nucleotide specificity of the activator and catalytic sites of a cGMP-stimulated cGMP phosphodiesterase from Dictyostelium discoideum [PDF]
, 1985 The cellular slime mold Dictyostelium discoideum has an intracellular phosphodiesterase which specifically hydrolyzes cGMP. The enzyme is activated by low cGMP concentrations, and is involved in the reduction of chemoattractant-mediated elevations of ...
Baraniak, Janina, +8 more
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Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis. [PDF]
, 2017 Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including the release of inflammatory mediators, mammalian target of rapamycin (mTOR) activation, and autophagy.
Castegna, Alessandra +12 more
core +8 more sources
Scientific Reports, 2023 The assembly state of enzymes is gaining interest as a mechanism for regulating the function of enzymes in living cells. One of the current topics in enzymology is the relationship between enzyme activity and the assembly state due to liquid–liquid phase
Tomoto Ura +7 more
doaj +1 more source
How does conformational flexibility influence key structural features involved in activation of anaplastic lymphoma kinase? [PDF]
, 2014 Anaplastic Lymphoma Kinase (ALK) plays a major role in developing tumor processes and therefore has emerged as a validated therapeutic target. Applying atomistic molecular dynamics simulations on the wild type enzyme and the nine most frequently ...
Adcock +28 more
core +1 more source
Activity of enzymes and fitness variation [PDF]
Genetics Selection Evolution, 1989 Uploaded by Plazi for TaxoDros. We do not have abstracts.
Milošević, M., Marinković, D.
openaire +7 more sources
An Extended Polyanion Activation Surface in Insulin Degrading Enzyme. [PDF]
PLoS ONE, 2015 Insulin degrading enzyme (IDE) is believed to be the major enzyme that metabolizes insulin and has been implicated in the degradation of a number of other bioactive peptides, including amyloid beta peptide (Aβ), glucagon, amylin, and atrial natriuretic ...
Eun Suk Song +9 more
doaj +1 more source
A new intrinsic thermal parameter for enzymes reveals true temperature optima [PDF]
, 2004 Two established thermal properties of enzymes are the Arrhenius activation energy and thermal stability. Arising from anomalies found in the variation of enzyme activity with temperature, a comparison has been made of experimental data for the activity ...
Daniel, Roy M. +4 more
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mBio, 2019 Carboxyl (C)-terminal processing proteases (CTPs) participate in protective and regulatory proteolysis in bacteria. The PDZ domain is central to the activity of CTPs but plays inherently different regulatory roles.
Chuang-Kai Chueh +5 more
doaj +1 more source
Activity of glucose oxidase functionalized onto magnetic nanoparticles [PDF]
, 2005 BACKGROUND: Magnetic nanoparticles have been significantly used for coupling with biomolecules, due to their unique properties. METHODS: Magnetic nanoparticles were synthesized by thermal co-precipitation of ferric and ferrous chloride using two ...
Irudayaraj, Joseph +2 more
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The effects of nitroxyl (HNO) on soluble guanylate cyclase activity: interactions at ferrous heme and cysteine thiols [PDF]
, 2009 It has been previously proposed that nitric oxide (NO) is the only biologically relevant nitrogen oxide capable of activating the enzyme soluble guanylate cyclase (sGC). However, recent reports implicate HNO as another possible activator of sGC.
Adrian J. Hobbs +85 more
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