Results 181 to 190 of about 651,887 (304)

Enzyme engineering of cytochrome P450 RosC provides mechanistic insights into factors controlling iterative oxidation. [PDF]

Appl Microbiol Biotechnol
Iizaka Y, Suzuki H, Sasa N, Ishiuchi K, Kumakiri Y, Kawasaki H, Sato H, Fujimoto K, Noguchi S, Anzai Y.   +9 more
europepmc   +1 more source

Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium: Integration of herbal medicine, enzyme engineering, and nanotechnology. [PDF]

J Pharm Anal, 2023
Lu Y, Luo Q, Jia X, Tam JP, Yang H, Shen Y, Li X.   +6 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

A generalized platform for artificial intelligence-powered autonomous enzyme engineering. [PDF]

Nat Commun
Singh N, Lane S, Yu T, Lu J, Ramos A, Cui H, Zhao H.   +6 more
europepmc   +1 more source

Computational Enzyme Engineering Pipelines for Optimized Production of Renewable Chemicals. [PDF]

Front Bioeng Biotechnol, 2021
Scherer M, Fleishman SJ, Jones PR, Dandekar T, Bencurova E.   +4 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Advances in microbial biofuel production by metabolic and enzyme engineering, synthetic biology, metagenomics, and genome editing applications. [PDF]

Emerg Top Life Sci
Alam SS, Mehdi A, Zafar A, Ali S, Rehman AU, Liaqat I, Peng L, Kanwal F, Afzal S, Haq IU, Aftab MN.   +10 more
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Electrostatic potential as a reactivity scoring function in computer-assisted enzyme engineering. [PDF]

FEBS J
Vega A, Planas A, Biarnés X.
europepmc   +1 more source

Improvement of a synthetic live bacterial therapeutic for phenylketonuria with biosensor-enabled enzyme engineering. [PDF]

Nat Commun, 2021
Adolfsen KJ, Callihan I, Monahan CE, Greisen PJ, Spoonamore J, Momin M, Fitch LE, Castillo MJ, Weng L, Renaud L, Weile CJ, Konieczka JH, Mirabella T, Abin-Fuentes A, Lawrence AG, Isabella VM.   +15 more
europepmc   +1 more source