Results 11 to 20 of about 651,887 (304)

Molecular, biochemical and kinetic analysis of a novel, thermostable lipase (LipSm) from Stenotrophomonas maltophilia Psi-1, the first member of a new bacterial lipase family (XVIII)

Journal of Biological Research - Thessaloniki, 2018
Background Microbial lipases catalyze a broad spectrum of reactions and are enzymes of considerable biotechnological interest. The focus of this study was the isolation of new lipase genes, intending to discover novel lipases whose products bear ...
Maria Parapouli, Athanasios Foukis, Panagiota-Yiolanda Stergiou, Maria Koukouritaki, Panagiotis Magklaras, Olga A. Gkini, Emmanuel M. Papamichael, Amalia-Sofia Afendra, Efstathios Hatziloukas   +8 more
doaj   +1 more source

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo. [PDF]

, 2014
Spores of some species of the strictly anaerobic bacteria Clostridium naturally target and partially lyse the hypoxic cores of tumors, which tend to be refractory to conventional therapies. The anti-tumor effect can be augmented by engineering strains to
Dubois, L, Ehsaan, M, Heap, JT, Knox, R, Kubiak, AM, Kuehne, SA, Lambin, P, Mellaert, LV, Minton, NP, Paesmans, K, Theys, J   +10 more
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Correction to: Molecular, biochemical and kinetic analysis of a novel, thermostable lipase (LipSm) from Stenotrophomonas maltophilia Psi‑1, the first member of a new bacterial lipase family (XIX)

Journal of Biological Research - Thessaloniki, 2018
We have recently (8th February 2018) published our article entitled “Molecular, biochemical and kinetic analysis of a novel, thermostable lipase (LipSm) from Stenotrophomonas maltophilia Psi-1, the first member of a new bacterial lipase family (XVIII ...
Maria Parapouli, Athanasios Foukis, Panagiota‑Yiolanda Stergiou, Maria Koukouritaki, Panagiotis Magklaras, Olga A. Gkini, Emmanuel M. Papamichael, Amalia‑Sofia Afendra, Efstathios Hatziloukas   +8 more
doaj   +1 more source

Synthetic biology—putting engineering into biology [PDF]

, 2006
Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we ...
Heinemann, Matthias,, Panke, Sven,
core   +1 more source

Biosynthesis of Sesquiterpenes in Basidiomycetes: A Review

Journal of Fungi, 2022
Sesquiterpenes are common small-molecule natural products with a wide range of promising applications and are biosynthesized by sesquiterpene synthase (STS). Basidiomycetes are valuable and important biological resources.
Jiajun Wu, Xiaoran Yang, Yingce Duan, Pengchao Wang, Jianzhao Qi, Jin-Ming Gao, Chengwei Liu   +6 more
doaj   +1 more source

Biocatalysis, Enzyme Engineering and Biotechnology [PDF]

, 2012
Enzymes are biocatalysts evolved in nature to achieve the speed and coordination of nearly all the chemical reactions that define cellular metabolism necessary to develop and maintain life.
Axarli, I. A., Chronopoulou, E. G., Karamitros, C., Kotzia, G. A., Labrou, N. E., Platis, D.   +5 more
core   +1 more source

Genome-wide study of Cerrena unicolor 87613 laccase gene family and their mode prediction in association with substrate oxidation

BMC Genomics, 2023
Background Laccases are green biocatalysts with wide industrial applications. The study of efficient and specific laccase producers remains a priority.
Long-Bin Zhang, Wu-Wei-Jie Yang, Ting-Ting Qiu   +2 more
doaj   +1 more source

Enzyme engineering in biomimetic compartments. [PDF]

, 2015
The success of a directed evolution approach to creating custom-made enzymes relies in no small part on screening as many clones as possible. The miniaturisation of assays into pico to femtoliter compartments (emulsion droplets, vesicles or gel-shell ...
Colin, Pierre-Yves, Hollfelder, Florian, Zinchenko, Anastasia   +2 more
core   +2 more sources

The chemical structures and biological activities of indole diterpenoids

Natural Products and Bioprospecting, 2023
Indole diterpenoids (IDTs) are an essential class of structurally diverse fungal secondary metabolites, that generally appear to be restricted to a limited number of fungi, such as Penicillium, Aspergillus, Claviceps, and Epichloe species, etc.
Jingwen Niu, Jianzhao Qi, Pengchao Wang, Chengwei Liu, Jin-ming Gao   +4 more
doaj   +1 more source

Engineering of GlcNAc-1-phosphotransferase for production of highly phosphorylated lysosomal enzymes for enzyme replacement therapy [PDF]

, 2017
Several lysosomal enzymes currently used for enzyme replacement therapy in patients with lysosomal storage diseases contain very low levels of mannose 6-phosphate, limiting their uptake via mannose 6-phosphate receptors on the surface of the deficient ...
Doray, Balraj, Kornfeld, Stuart, Lee, Wang-Sik, Liu, Lin   +3 more
core   +3 more sources