Results 31 to 40 of about 651,887 (304)
High-efficient production of mushroom polyketide compounds in a platform host Aspergillus oryzae
Microbial Cell Factories, 2023 Background Orsellinic acid (2,4-dihydroxy-6-methylbenzoic acid, OA) and its structural analog o-Orsellinaldehyde, have become widely used intermediates in clinical drugs synthesis.
Haiyan Han +8 more
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Engineering productive enzyme confinement [PDF]
Trends in Biotechnology, 2007 Natural enzymes were selected to function inside the cell, not in the test tube; therefore, their performance is optimized for the crowded conditions encountered in vivo. Most man-made matrices for enzyme confinement lead to suboptimal catalytic activity.
A Keith, Dunker, Ariel, Fernández
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Physics-based visual characterization of molecular interaction forces [PDF]
, 2017 Molecular simulations are used in many areas of biotechnology, such as drug design and enzyme engineering. Despite the development of automatic computational protocols, analysis of molecular interactions is still a major aspect where human comprehension ...
Estrada, Jorge +5 more
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Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools. [PDF]
, 2020 Appropriate empirical-based evidence and detailed theoretical considerations should be used for evolutionary explanations of phenotypic variation observed in the field of human population genetics (especially Indigenous populations). Investigators within
Fox, Keolu +2 more
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MycologyThe medicinal mushroom Inonotus obliquus is renowned for producing a wide array of pharmacologically active terpenoids, yet the enzymatic basis for this diversity remains partially elusive.
Yingce Duan +5 more
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CHIMIA, 1975 Design procedures for enzyme reactors do not differ fundamentally from those of conventional catalytic reactors. Initially, the decision must be made whether continuous operation has economic advantages over batchwise processing. Generally, a continuous
Irving J. Dunn
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Enzymatic functionalization of carbon-hydrogen bonds [PDF]
, 2011 The development of new catalytic methods to functionalize carbon–hydrogen (C–H) bonds continues to progress at a rapid pace due to the significant economic and environmental benefits of these transformations over traditional synthetic methods.
Arnold, Frances H. +2 more
core +1 more source
Computer simulations explain mutation-induced effects on the DNA editing by adenine base editors. [PDF]
, 2020 Adenine base editors, which were developed by engineering a transfer RNA adenosine deaminase enzyme (TadA) into a DNA editing enzyme (TadA*), enable precise modification of A:T to G⋮C base pairs. Here, we use molecular dynamics simulations to uncover the
Komor, Alexis C +2 more
core
Toward eradication of B-vitamin deficiencies : considerations for crop biofortification [PDF]
, 2018 'Hidden hunger' involves insufficient intake of micronutrients and is estimated to affect over two billion people on a global scale. Malnutrition of vitamins and minerals is known to cause an alarming number of casualties, even in the developed world ...
Strobbe, Simon +1 more
core +3 more sources
Enzyme Cascade Reaction Engineering
, 2021 Biocatalytic transformations are of growing interest due to their high chemo-, regio-, and enantioselectivity, sustainability, and biocompatibility. In order to build on these advantages, to reinforce them, and not to weaken them, as well as to ensure the fulfillment of economic framework conditions, it is important to harmonize the reaction with its ...
Petermeier, Philipp, Kara, Selin
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