Results 61 to 70 of about 651,887 (304)

The alkynyl-containing compounds from mushrooms and their biological activities

Natural Products and Bioprospecting, 2023
Mushrooms have been utilized by humans for thousands of years due to their medicinal and nutritional properties. They are a crucial natural source of bioactive secondary metabolites, and recent advancements have led to the isolation of several alkynyl ...
Ji-shuang Qi, Yingce Duan, Zhao-chen Li, Jin-ming Gao, Jianzhao Qi, Chengwei Liu   +5 more
doaj   +1 more source

Study of Enzymatic Hydrolysis of Dilute Acid Pretreated Coconut Husk [PDF]

, 2012
Coconut husk is classified as complex lignocellulosic material that contains cellulose, hemicellulose, lignin, and some other extractive compounds. Cellulose from coconut husk can be used as fermentation substrate after enzymatic hydrolysis. In contrary,
Agustriyanto, Rudy, Fatmawati, Akbarningrum, Liasari, Yusnita   +2 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Tri©DB: an integrated platform of knowledgebase and reporting system for cancer precision medicine

Journal of Translational Medicine, 2023
Background With the development of cancer precision medicine, a huge amount of high-dimensional cancer information has rapidly accumulated regarding gene alterations, diseases, therapeutic interventions and various annotations.
Wei Jiang, Peng-Ying Wang, Qi Zhou, Qiu-Tong Lin, Yao Yao, Xun Huang, Xiaoming Tan, Shihui Yang, Weicai Ye, Yuedong Yang, Yun-Juan Bao   +10 more
doaj   +1 more source

Accessing Nature’s diversity through metabolic engineering and synthetic biology [PDF]

, 2016
In this perspective, we highlight recent examples and trends in metabolic engineering and synthetic biology that demonstrate the synthetic potential of enzyme and pathway engineering for natural product discovery.
Edgar, Steven McBride, King, Jason R, Qiao, Kangjian, Stephanopoulos, Gregory   +3 more
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Recent advances in Flavin-dependent halogenase biocatalysis : sourcing, engineering, and application [PDF]

, 2019
The introduction of a halogen atom into a small molecule can effectively modulate its properties, yielding bioactive substances of agrochemical and pharmaceutical interest.
Buller, Rebecca, Büchler, Johannes, Papadopoulou, Athena   +2 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A Whole-Process Visible Strategy for the Preparation of Rhizomucor miehei Lipase with Escherichia coli Secretion Expression System and the Immobilization

Microbial Cell Factories
Background Rhizomucor miehei (RM) lipase is a regioselective lipase widely used in food, pharmaceutical and biofuel industries. However, the high cost and low purity of the commercial RM lipase limit its industrial applications.
Mingjun Yang, Xianhui Su, Jun Yang, Zhiwen Lu, Jie Zhou, Fei Wang, Yang Liu, Lixin Ma, Chao Zhai   +8 more
doaj   +1 more source

Engineering Pichia pastoris with surface-display minicellulosomes for carboxymethyl cellulose hydrolysis and ethanol production

Biotechnology for Biofuels, 2020
Backgrounds Engineering yeast as a consolidated bioprocessing (CBP) microorganism by surface assembly of cellulosomes has been aggressively utilized for cellulosic ethanol production.
Ce Dong, Jie Qiao, Xinping Wang, Wenli Sun, Lixia Chen, Shuntang Li, Ke Wu, Lixin Ma, Yi Liu   +8 more
doaj   +1 more source