Results 1 to 10 of about 4,886,955 (347)

Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme [PDF]

, 2010
Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP ...
Andrew C. Hemmert, C. Linn Cadieux, Carol C. Edwards, Douglas M. Cerasoli, Fernando Rodrigues-Lima, John R. Cashman, Jonathan S. Edwards, Lyudmila Tsurkan, Matthew R. Redinbo, Monika Wierdl, Philip M. Potter, Roberto A. Chica, Shane A. Kasten, Stephen L. Mayo, Steven M. Lewis, Tamara C. Otto   +15 more
core   +14 more sources

Aesculin based glucosamine-6-phosphate synthase inhibitors as novel preservatives for food and pharmaceutical products: in-silico studies, antioxidant, antimicrobial and preservative efficacy evaluation

BMC Chemistry, 2021
Background Presently available chemical based synthetic preservative have emerged with various side effects, so the aspiration of natural and side effect free novel preservative has been greatly increased.
Amit Lather, Sunil Sharma, Anurag Khatkar   +2 more
doaj   +1 more source

Inhibition Properties of Some Pyrimidine Derivatives as Anticancer Agents on Glutathione S-Transferase

Van Tıp Dergisi, 2021
INTRODUCTION: Glutathione S-transferase (GST; EC 2.5.1.18), which is a member of the family of transferase enzymes, is an enzyme that has a very important role in maintaining the internal and external balance of the body by catalyzing the first stage of ...
Hatice Esra Duran
doaj   +1 more source

Valonea Tannin: Tyrosinase Inhibition Activity, Structural Elucidation and Insights into the Inhibition Mechanism

Molecules, 2021
Valonea tannin is a natural product readily extracted from acorn shells that has been suggested to have potential skin whitening properties. This study investigated the tyrosinase inhibition activity of extracted valonea tannin and the associated ...
Jiaman Liu, Yuqing Liu, Xiaofeng He, Bo Teng, Jacqui M. McRae   +4 more
doaj   +1 more source

Tyrosinase Inhibition Ability Provided by Hop Tannins: A Mechanistic Investigation

Biology and Life Sciences Forum, 2021
The hop is rich in tannins used as a conventional additive in the beer industry, but other applications are limited. This study investigated the tyrosinase inhibition activity of extracted hop tannins and the associated structure–function activity.
Jiaman Liu, Yanbiao Chen, Xinxin Zhang, Jie Zheng, Jiaying Wang, Weiying Hu, Bo Teng   +6 more
doaj   +1 more source

Naringin derivatives as glucosamine-6-phosphate synthase inhibitors based preservatives and their biological evaluation

Scientific Reports, 2020
Glucosamine-6-Phosphate synthase enzyme has been targeted for development of better and safe preservative due to its role in microbial cell wall synthesis.
Amit Lather, Sunil Sharma, Anurag Khatkar   +2 more
doaj   +1 more source

Naringenin derivatives as glucosamine-6-phosphate synthase inhibitors: synthesis, antioxidants, antimicrobial, preservative efficacy, molecular docking and in silico ADMET analysis

BMC Chemistry, 2020
Background Preservatives have to be added in food, pharmaceuticals and cosmetics products to maintain their shelf life. However, the existing chemical based preservatives have been associated with severe side effects that compel the researchers to find ...
Amit Lather, Sunil Sharma, Anurag Khatkar   +2 more
doaj   +1 more source

Lead optimization for promising monoamine oxidase inhibitor from eugenol for the treatment of neurological disorder: synthesis and in silico based study

BMC Chemistry, 2019
Natural based inhibitors of monoamine oxidase are promising drug candidates for the treatment of several neurodegenerative and neuropsychological disorders including depression, anxiety, Parkinson’s disease and Alzheimer’s disease.
Priyanka Dhiman, Neelam Malik, Anurag Khatkar   +2 more
doaj   +1 more source

Natural based piperine derivatives as potent monoamine oxidase inhibitors: an in silico ADMET analysis and molecular docking studies

BMC Chemistry, 2020
Neurodegenerative disorders follow numerous pathological ways concerning overexpression of monoamine oxidase and formation of reactive oxygen species.
Priyanka Dhiman, Neelam Malik, Anurag Khatkar   +2 more
doaj   +1 more source

Optimal designs for enzyme inhibition kinetic models [PDF]

, 2017
In this paper we present a new method for determining optimal designs for enzyme inhibition kinetic models, which are used to model the influence of the concentration of a substrate and an inhibition on the velocity of a reaction.
Dette, Holger, Kettelhake, Katrin, Möller, Tilman, Schorning, Kirsten   +3 more
core   +2 more sources