Results 1 to 10 of about 4,881,257 (236)
Current Bioactive Compounds, 2007 One aspect of the importance of enzymes in biology can be appreciated by considering the attention that continues to be focused on the inhibition of enzymatic activity. Historically, inhibitors played important roles in the elucidation of metabolic pathways.
Perry A. Frey, Adrian D. Hegeman
semanticscholar +4 more sources
Sensors, 2018 A large number of enzyme inhibitors are used as drugs to treat several diseases such as gout, diabetes, AIDS, depression, Parkinson’s and Alzheimer’s diseases. Electrochemical biosensors based on enzyme inhibition are useful devices for an easy, fast and
Loubna El Harrad +3 more
doaj +2 more sources
Biosensors Based on Enzyme Inhibition [PDF]
Advances in Biochemical Engineering/Biotechnology, 2013 The present chapter describes the use of biosensors based on enzyme inhibition as analytical tools. The parameters that affect biosensor sensitivity, such as the amount of immobilized enzyme, incubation time, and immobilization type, were critically evaluated, highlighting how the knowledge of enzymatic kinetics can help researchers optimize the ...
ARDUINI, FABIANA, Amine, A.
openaire +4 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 The formal mechanism of linear mixed and non-competitive enzyme inhibition implies the binding of inhibitors to both the active site of the free enzyme in competition with the substrate, and to an allosteric site on the enzyme-substrate complex. However,
A. Pesaresi
semanticscholar +1 more source
Journal of Medicinal Chemistry, 2021 Here, we report the synthesis, structure–activity relationship studies, enzyme inhibition, antiviral activity, and X-ray crystallographic studies of 5-chloropyridinyl indole carboxylate derivatives as a potent class of SARS-CoV-2 chymotrypsin-like ...
Arun K. Ghosh +9 more
semanticscholar +1 more source
BMC Chemistry, 2021 Background Presently available chemical based synthetic preservative have emerged with various side effects, so the aspiration of natural and side effect free novel preservative has been greatly increased.
Amit Lather +2 more
doaj +1 more source
Van Tıp Dergisi, 2021 INTRODUCTION: Glutathione S-transferase (GST; EC 2.5.1.18), which is a member of the family of transferase enzymes, is an enzyme that has a very important role in maintaining the internal and external balance of the body by catalyzing the first stage of ...
Hatice Esra Duran
doaj +1 more source
Molecules, 2021 Valonea tannin is a natural product readily extracted from acorn shells that has been suggested to have potential skin whitening properties. This study investigated the tyrosinase inhibition activity of extracted valonea tannin and the associated ...
Jiaman Liu +4 more
doaj +1 more source
Tyrosinase Inhibition Ability Provided by Hop Tannins: A Mechanistic Investigation
Biology and Life Sciences Forum, 2021 The hop is rich in tannins used as a conventional additive in the beer industry, but other applications are limited. This study investigated the tyrosinase inhibition activity of extracted hop tannins and the associated structure–function activity.
Jiaman Liu +6 more
doaj +1 more source
Scientific Reports, 2020 Glucosamine-6-Phosphate synthase enzyme has been targeted for development of better and safe preservative due to its role in microbial cell wall synthesis.
Amit Lather +2 more
doaj +1 more source