Results 171 to 180 of about 783,012 (204)

Quantitative structure–activity study of some enzyme‐inhibitory quinazolines

International Journal of Quantum Chemistry, 1980
AbstractRelationships are formulated to explain the variation in dihydrofolate reductase inhibitory potency for a series of 25 substituted quinazolines, with an antineoplastic potential. Highly significant correlations are obtained using CNDO/2–3R calculated indices and/or the empirically estimated molecular polarizability as independent variables. The
P. G. Abdul‐Ahad, T. Blair, G. A. Webb
openaire   +1 more source

Screening of angiotensin-converting enzyme inhibitory activities in microalgae

Journal of Applied Phycology, 1989
As part of the investigation on useful constituents in microalgae, we searched for angiotensin converting enzyme inhibitory activities in water-soluble and fat-soluble fractions of sixteen species and strains. Water-soluble fractions of eleven species and fat-soluble fractions of eight species showed inhibitory activities.
Katsumi Yamaguchi, Masahiro Murakami, Tatsufumi Okino   +2 more
openaire   +1 more source

Big Endothelin Analogues with Inhibitory Activity on Endothelin-Converting Enzyme-1

Journal of Cardiovascular Pharmacology, 1998
Big endothelin-1 (big ET-1) is converted into an active form, ET-1, by endothelin-converting enzyme-1 (ECE-1). To assess the mechanism of substrate recognition by ECE-1, we examined the effects of variously substituted analogues of big ET-1 on ECE-1 activity, using solubilized membranes prepared from human ECE-1-expressed CHO-K1 cells. Among the big ET-
R, Takayanagi, W, Liu, T, Ito, K, Ohnaka, H, Nawata   +4 more
openaire   +2 more sources

Angiotensin converting enzyme inhibitory activity of amino acid esters of carbohydrates

International Journal of Biological Macromolecules, 2006
L-alanyl-D-glucose, L-valyl-D-glucose, L-phenylalanyl-D-glucose and L-phenylalanyl-lactose esters were synthesized enzymatically using two lipases viz., Rhizomucor miehei lipase (RML) and porcine pancreas lipase (PPL) and tested for their potential as inhibitors of angiotensin converting enzyme (ACE) in vitro. The esters exhibited concentration related
Vasudeva, Kamath, P S, Rajini, K, Lohith, B R, Somashekar, S, Divakar   +4 more
openaire   +2 more sources

Phenolic Composition, Antioxidant and Enzyme Inhibitory Activities of Eryngium bornmuelleri leaf

Plant Foods for Human Nutrition, 2013
Eryngium bornmuelleri Nab. (Tusî) is an endemic botanical from the Eastern Anatolia region of Turkey traditionally used for preparation of herbal tea. Within this study, phenolic composition, antioxidant capacities and inhibitory activities towards selected digestive enzymes of E. bornmuelleri leaf were investigated.
Türker, Musa, Dalar, Abdullah, KONCZAK, Izabela, ZABARAS, Dimitrios   +3 more
openaire   +4 more sources

Inhibitory activity of Plantago major L. on angiotensin I-converting enzyme

Archives of Pharmacal Research, 2011
Eight compounds were isolated from methanol extract of Plantago major L. leaves and investigated for their ability to inhibit angiotensin I-converting enzyme activity. Among them, compound 1 showed the most potent inhibition with rate of 28.06 ± 0.21% at a concentration of 100 μM. Compounds 2 and 8 exhibited weak activities.
Nguyen Xuan, Nhiem, Bui Huu, Tai, Phan, Van Kiem, Chau, Van Minh, Nguyen Xuan, Cuong, Nguyen Huu, Tung, Vu Kim, Thu, Trinh Nam, Trung, Hoang Le Tuan, Anh, Sung-Hoon, Jo, Hae-Dong, Jang, Young-In, Kwon, Young Ho, Kim   +12 more
openaire   +2 more sources

Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity

Xenobiotica, 2010
Commonly used herbal supplements were screened for their potential to inhibit UGT1A1 activity using human liver microsomes. Extracts screened included ginseng, echinacea, black cohosh, milk thistle, garlic, valerian, saw palmetto, and green tea epigallocatechin gallate (EGCG).
Mohamed-Eslam F, Mohamed, Tiffany, Tseng, Reginald F, Frye   +2 more
openaire   +2 more sources

Screening of African medicinal plants for antimicrobial and enzyme inhibitory activity

Journal of Ethnopharmacology, 2002
Seven plant species, belonging to different families, were collected in the eastern part of the Republic of Congo (Kivu) based on ethnopharmacological information. Their dichloromethane and methanolic extracts were tested for biological activity. Five of the seven collected plants exhibited antiplasmodial activity with IC(50) values ranging from 1.1 to
Jeannette Ndaya, Tshibangu, Kusamba, Chifundera, Ronald, Kaminsky, Anthony David, Wright, Gabriele Maria, König   +4 more
openaire   +2 more sources

Milk Protein Peptides With Angiotensin I-Converting Enzyme Inhibitory (ACEI) Activity

Critical Reviews in Food Science and Nutrition, 2010
Bioactive peptides derived from milk proteins are currently of great scientific interest due to their beneficial health properties. The group of bioactive peptides most studied up until now are the angiotensin-I converting enzyme inhibitory (ACEI) peptides, which, when administered orally, seem to possess the capacity to lower blood pressure in ...
Ignacio, Ricci, Reyes, Artacho, Manuel, Olalla   +2 more
openaire   +2 more sources

Acaricidal activity and enzyme inhibitory activity of active compounds of essential oils against Psoroptes cuniculi

Veterinary Parasitology, 2019
Plant essential oils and its chemical compositions are commonly applied in medicinal and other industries due to their broad advanced pharmacological activities. In the present study, we systematically evaluated the acaricidal activities of twelve compounds of essential oils against Psoroptes cuniculi in vitro and in vivo.
Xiao-Fei, Shang, Li-Xia, Dai, Ying-Qian, Liu, Zhong-Min, Zhao, Jun-Cai, Li, Guan-Zhou, Yang, Cheng-Jie, Yang   +6 more
openaire   +2 more sources