Results 11 to 20 of about 1,224,230 (307)
Enzyme-Catalyzed Kinetic Resolution of Chiral Precursors to Antiviral Prodrugs [PDF]
Biochemistry, 2019 Nucleoside analogues are among the most common medications given for the treatment of viral infections and cancers. The therapeutic effectiveness of nucleoside analogues can be dramatically improved by phosphorylation. The ProTide approach was developed using a phosphorylated nucleoside that is masked by esterification with an amino acid and phenol ...
Dao Feng Xiang +4 more
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Foods, 2023 Cocoa fermentation is an essential process that produces flavor precursors. However, many small farmers in Indonesia directly dry their cocoa beans without fermentation due to low yield and long fermentation time, resulting in fewer flavor precursors and
Krisna Purbaningrum +3 more
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Enzyme associations in T4 phage DNA precursor synthesis [PDF]
Proceedings of the National Academy of Sciences, 1977 A direct approach is described to the question: Are enzymes of DNA precursor synthesis organized into a supramolecular structure? This approach involved sedimentation analysis of several T4 phage-coded early enzyme activities in crude lysates of infected Escherichia coli .
G P, Reddy +3 more
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Marine Drugs, 2018 Marine invertebrates, such as sponges, tunicates and cnidarians (zoantharians and scleractinian corals), form functional assemblages, known as holobionts, with numerous microbes.
Jean-Étienne R. L. Morlighem +7 more
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Distinct functional and temporal requirements for zebrafish Hdac1 during neural crest-derived craniofacial and peripheral neuron development. [PDF]
PLoS ONE, 2013 The regulation of gene expression is accomplished by both genetic and epigenetic means and is required for the precise control of the development of the neural crest. In hdac1(b382) mutants, craniofacial cartilage development is defective in two distinct
Myron S Ignatius +5 more
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The properties of nerve cell precursors in hydra [PDF]
, 1986 Two signals, the head activator and an injury stimulus, control differentiation of nerve cells from uncommitted stem cells in hydra [Th. Holstein, H. C. Schaller, and C. N. David, (1986) Dev. Biol. 115, 9–17].
Holstein, Thomas W., David, Charles N.
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Quantitative and evolutionary global analysis of enzyme reaction mechanisms [PDF]
, 2015 The most widely used classification system describing enzyme-catalysed reactions is the Enzyme Commission (EC) number. Understanding enzyme function is important for both fundamental scientific and pharmaceutical reasons.
Nath, Neetika
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Microbial Cell Factories, 2021 Background The aryltetralin lignan (−)−podophyllotoxin is a potent antiviral and anti-neoplastic compound that is mainly found in Podophyllum plant species. Over the years, the commercial demand for this compound rose notably because of the high clinical
Davide Decembrino +4 more
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Structural and Functional Adaptation of Vancomycin Resistance VanT Serine Racemases
mBio, 2015 Vancomycin resistance in Gram-positive bacteria results from the replacement of the d-alanyl–d-alanine target of peptidoglycan precursors with d-alanyl–d-lactate or d-alanyl–d-serine (d-Ala-d-Ser), to which vancomycin has low binding affinity.
Djalal Meziane-Cherif +5 more
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Redox Biology, 2021 The antioxidant function of the phospholipid hydroperoxide glutathione peroxidase (GPx4) is vital for the homeostasis of many cell types, from neoplastic cells to normal erythroid precursors.
Jeffrey M. Stolwijk +6 more
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