Results 41 to 50 of about 355,555 (310)

Prothrombin concentrations in middle-aged men and women – stability over time and correlations with cardiovascular risk factors

Thrombosis Update
Background: Prothrombin is a vitamin K-dependent glycoprotein synthesized in the liver and circulating in blood as an inactive zymogen. The corresponding activated thrombin enzyme is a central player in hemostasis and thrombosis.
Bengt Zöller, Mark Jonas Haastrup, Niels Tækker Foged, Gunnar Engström   +3 more
doaj   +1 more source

Successive translocation into and out of the mitochondrial matrix [PDF]

, 1987
We investigated the import and sorting pathways of cytochrome b2 and cytochrome c1, which are functionally located in the intermembrane space of mitochondria.
Alt, Appleby, Bradford, Böhni, Chen, Conboy, Daum, Dowhan, Duffaud, Eilers, Fujiki, Gabellini, Gabellini, Gasser, Gasser, Gubler, Guiard, Hallermayer, Harmey, Hartl, Hartl, Hartl, Hauska, Hay, Hayashi, Horwich, Hurt, Hurt, Hurt, Kaput, Kolanski, Krieg, Laemmli, Lewin, Li, McAda, Miura, Ohashi, Pelham, Perara, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pratje, Riezmann, Rottier, Römisch, Sadler, Schatz, Schleyer, Schleyer, Schmidt, Schmidt, Schwaiger, Simon, Smeekens, Stueber, Talmadge, Teintze, van Loon, van Loon, van Loon, Voordouw, Zimmermann, Zwizinski   +67 more
core   +1 more source

MOF-derived Porous NiO Nanorod and Microflower Structures with Enhanced Non-enzymatic Glucose Electrochemical Sensing Performance

International Journal of Electrochemical Science, 2021
The porous and hierarchical structure with plentiful electroactive sites may ensure high activity and stability in electrocatalytic oxidation glucose by accelerating the transport of analyzer and electron during the electrochemical process.
Xiaobei Zhang, Rui Wang, Yaqing Wei, Xiaoqi Pei, Zhuo Zhou, Jingchao Zhang, Renchun Zhang, Daojun Zhang   +7 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Biogenesis of Glyoxysomes [PDF]

, 1980
Biosynthesis of isocitrate lyase, a tetrameric enzyme of the glyoxysomal matrix, was studied in Neurospora crassa, in which the formation of glyoxysomes was induced by a substitution of sucrose medium by acetate medium. * 1.
Neupert, Walter, Zimmermann, Richard
core   +1 more source

Toxoplasma gondii relies on both host and parasite isoprenoids and can be rendered sensitive to atorvastatin. [PDF]

PLoS Pathogens, 2013
Intracellular pathogens have complex metabolic interactions with their host cells to ensure a steady supply of energy and anabolic building blocks for rapid growth.
Zhu-Hong Li, Srinivasan Ramakrishnan, Boris Striepen, Silvia N J Moreno   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Biocatalysis for the Production of Pharmaceutical Intermediates: Statin Precursors [PDF]

Kemija u Industriji, 2019
The application of enzymes in chemical synthesis, due to the recent advances, has a strong impact in multiple industries, especially the pharmaceutical industry. Namely, the use of enzymes shows remarkable advantages over classical chemical catalysis and
Anera Švarc, Dino Skendrović, Ana Vrsalović Presečki   +2 more
doaj   +1 more source

Interconnected Set of Enzymes Provide Lysine Biosynthetic Intermediates and Ornithine Derivatives as Key Precursors for the Biosynthesis of Bioactive Secondary Metabolites

Antibiotics, 2023
Bacteria, filamentous fungi, and plants synthesize thousands of secondary metabolites with important biological and pharmacological activities. The biosynthesis of these metabolites is performed by networks of complex enzymes such as non-ribosomal ...
Paloma Liras, Juan Francisco Martín
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source