Results 71 to 80 of about 3,038,812 (378)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Cyanobacteria: A Promising Source of Antifungal Metabolites

Marine Drugs, 2023
Cyanobacteria are a rich source of secondary metabolites, and they have received a great deal of attention due to their applicability in different industrial sectors. Some of these substances are known for their notorious ability to inhibit fungal growth.
Samuel Cavalcante do Amaral, Luciana Pereira Xavier, Vítor Vasconcelos, Agenor Valadares Santos   +3 more
doaj   +1 more source

Information propagation in time through allosteric signaling [PDF]

Phys. Rev. Research 2, 023367 (2020), 2019
Naively, one expects the information communicated by an enzyme downstream within a signaling network, in which the enzyme is embedded, to grow monotonically with the enzyme's rate of product formation. However, here we observe that this does not necessarily hold true for allosterically regulated enzymes, often observed in signaling networks.
arxiv   +1 more source

New Insights Into Sunflower (Helianthus annuus L.) FatA and FatB Thioesterases, Their Regulation, Structure and Distribution [PDF]

, 2018
Sunflower seeds (Helianthus annuus L.) accumulate large quantities of triacylglycerols (TAG) between 12 and 28 days after flowering (DAF). This is the period of maximal acyl-acyl carrier protein (acyl-ACP) thioesterase activity in vitro, the enzymes that
Antonio J. Moreno-Pérez, Enrique Martínez-Force, Joaquín J. Salas, Jose A. Aznar-Moreno, Mónica Venegas Calerón, Mónica Venegas Calerón, Rafael Garcés, Robert T. Mullen, Rosario Sánchez, Satinder K. Gidda   +9 more
core   +3 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Immune System Abnormalities in Schizophrenia: An Integrative View and Translational Perspectives

Frontiers in Psychiatry, 2022
The immune system is generally known to be the primary defense mechanism against pathogens. Any pathological conditions are reflected in anomalies in the immune system parameters.
Evgeny A. Ermakov, Evgeny A. Ermakov, Mark M. Melamud, Valentina N. Buneva, Valentina N. Buneva, Svetlana A. Ivanova   +5 more
doaj   +1 more source

Microtubule-severing enzymes: From cellular functions to molecular mechanism. [PDF]

, 2018
Microtubule-severing enzymes generate internal breaks in microtubules. They are conserved in eukaryotes from ciliates to mammals, and their function is important in diverse cellular processes ranging from cilia biogenesis to cell division, phototropism ...
Ahmad, Akhmanova, Akhmanova, Allison, Antonina Roll-Mecak, Aubin-Tam, Banks, Barton, Benz, Bichet, Burk, Burk, Carlier, Carlier, Carlier, Charafeddine, Cheung, Chi, Connell, Denton, DeSantis, DesMarais, Dominguez, Dong, Doyle, Dymek, Dymek, Díaz-Valencia, Eckert, Evans, Francis J. McNally, Ganem, Gates, Grode, Guizetti, Han, Hara, Hartman, Hartman, Hawkins, Hazan, Hu, Hu, Iwaya, Jiang, Jiang, Jiang, Johjima, Joly, Kasher, Keating, Lacroix, Lata, Lee, Leo, Lindeboom, Liu, Loughlin, Lundin, Lučič, Maillard, Mains, Mao, Matsuo, McNally, McNally, McNally, McNally, McNally, McNally, Minoura, Mishra-Gorur, Mitchison, Monroe, Moretti, Mukherjee, Murata, Nakamura, Nicklas, Nithianantham, Olivares, Park, Peng, Portis, Puchades, Qiang, Rao, Reid, Rezabkova, Ribbeck, Rogers, Roll-Mecak, Roll-Mecak, Roll-Mecak, Roll-Mecak, Sharma, Sharp, Shaw, Sherwood, Sonbuchner, Srayko, Stamatakis, Stewart, Stone, Tao, Taylor, Ti, Tirnauer, Tran, Trotta, Vale, Valenstein, Vemu, Vemu, Vietri, Walker, Wang, Waterman-Storer, Wen, White, Whitehead, Wightman, Yang, Yang, Yang, Yu, Zehr, Zhang, Zhang, Zhang, Zhao   +130 more
core   +2 more sources

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Diversity and function of phage encoded depolymerases [PDF]

, 2020
Bacteriophages of the Podoviridae family often exhibit so-called depolymerases as structural components of the virion. These enzymes appear as tail spike proteins (TSPs).
Fieseler, Lars, Knecht, Leandra E., Veljkovic, Marjan   +2 more
core   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source