Results 101 to 110 of about 162,632 (357)

UniMap: Type‐Level Integration Enhances Biological Preservation and Interpretability in Single‐Cell Annotation

Advanced Science, Volume 12, Issue 16, April 24, 2025.
UniMap introduces a novel multiselective adversarial network that functions as a discerner in single‐cell dataset integration. It enables type‐level integration, ensuring accurate cell type annotation across diverse biological contexts while preserving shared and domain‐specific features.
Haitao Hu, Yue Guo, Fujing Ge, Hao Yin, Hao Zhang, Zhesheng Zhou, Fangjie Yan, Qing Ye, Jialu Wu, Ji Cao, Chang‐Yu Hsieh, Bo Yang   +11 more
wiley   +1 more source

Clinical Utility of Machine Learning Methods Using Regression Models for Diagnosing Eosinophilic Chronic Rhinosinusitis

OTO Open
Objective Machine learning methods using regression models can predict actual values of histological eosinophil count from blood eosinophil levels. Therefore, these methods might be useful for diagnosing eosinophilic chronic rhinosinusitis, but their ...
Hiroatsu Hatsukawa, Masaaki Ishikawa
doaj   +1 more source

The value of peripheral blood eosinophil count in predicting in-stent restenosis in patients with stable angina pectoris undergoing drug eluting stenting

Romanian Journal of Internal Medicine, 2017
Introduction. In-stent restenosis (ISR) remains a major limitation of percutaneous coronary intervention (PCI). A role for peripheral blood cells as major regulators of immune and inflammatory systems has been proposed.
Hajizadeh Reza, Ghaffari Samad, Separham Ahmad, Shokouhi Behrouz, Kavandi Hadiseh, Pourafkari Leili, Nader Nader D.   +6 more
doaj   +1 more source

A Spleen‐Targeted Tolerogenic mRNA‐LNPs Vaccine for the Treatment of Experimental Asthma

Advanced Science, Volume 12, Issue 13, April 3, 2025.
Splenic DCs‐targeted co‐delivery of nucleoside‐modified antigen mRNA and Cel‐loaded LNPs vaccine induces tolerogenic DCs and subsequent antigen‐specific CD4+ regulatory T cells for the treatment of experimental allergic asthma. Abstract Lipid nanoparticles (LNPs)‐based mRNA vaccines have witnessed their great advantages in the fight against infectious ...
Fazhan Wang, Jia Lou, Xiaohan Lou, Fang Wu, Xiaoke Gao, Xiaohan Yao, Jiajia Wan, Xixi Duan, Wenjing Deng, Lixia Ma, Lijing Zhang, Guangjie He, Ming Wang, Chen Ni, Ningjing Lei, Zhihai Qin   +15 more
wiley   +1 more source

Recombinant human interleukin 5 is a selective activator of human eosinophil function

Journal of Experimental Medicine, 1988
Human rIL-5 was found to selectively stimulate morphological changes and the function of human eosinophils. This molecule is thus a prime candidate for the selective eosinophilia and eosinophil activation seen in disease.
Angel Lopez, C. Sanderson, J. Gamble, H. Campbell, I. Young, M. Vadas   +5 more
semanticscholar   +1 more source

Multifunctional Boron‐based 2D Nanoplatforms Ameliorate Severe Respiratory Inflammation by Targeting Multiple Inflammatory Mediators

Advanced Science, Volume 12, Issue 13, April 3, 2025.
There are many limitations of conventional corticosteroids in the treatment of respiratory inflammation. Here, a multifunctional 2D nanoplatform is designed that simultaneously targets cfDNA, NETs, RONS, and bacterial infection. The nanoplatforms exhibited excellent therapeutic efficacy in vivo and could serve as a new therapeutic approach for severe ...
Changyi Xu, Ming Liu, Xinran Xie, Zhixin Li, Yuefei Zhu, Yang Ye, Mengya Du, Suhua Hu, Tianrun Liu, Yubiao Guo, Weiping Wen, Huanliang Liu, Zhaoxu Tu   +12 more
wiley   +1 more source

Clinical Significance of Interleukin 33 (IL-33) in Patients with Eosinophilic Pneumonia

Allergology International, 2013
Background: Interleukin 33 (IL-33) works as a functional mediator in allergic disease by enhancing the activity of eosinophils and inducing expression of T helper 2 (Th2)-associated cytokines.
Naoko Mato, Masashi Bando, Aya Kusano, Toshikatsu Hirano, Masayuki Nakayama, Tomohiro Uto, Takakiyo Nakaya, Hideaki Yamasawa, Yukihiko Sugiyama   +8 more
doaj   +1 more source

The Innate Immune Sensor Zbp1 Mediates Central Nervous System Inflammation Induced by Angiostrongylus Cantonensis by Promoting Macrophage Inflammatory Phenotypes

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This study reveals that Zbp1 plays a pivotal role in regulating neuroimmune interactions during Angiostrongylus cantonensis (AC) infection. Zbp1 modulates lymphocyte infiltration and natural killer (NK) cell cytotoxicity by promoting cytokine secretion and M1 polarization of macrophages, shaping the CNS immune microenvironment.
Hongli Zhou, Minyu Zhou, XiPing Liao, Liangyu Zhang, Hang Wei, Yuting Lu, Yiqing Zhang, Hui Huang, Yue Hu, Tao Chen, Zhiyue Lv   +10 more
wiley   +1 more source

Metformin: A potential adjunct for treatment of systemic mastocytosis

Journal of Allergy and Clinical Immunology: Global
Background: Systemic mastocytosis (SM) is a clonal disorder of mast cells in which the KIT Asp816Val mutation can be detected not only in mature mast cells but also in the hematopoietic stem cell and in non–mast cell lineages.
Joseph H. Butterfield, MD, Kathleen Bartemes, PhD   +1 more
doaj  

Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation

Journal of Experimental Medicine, 1994
Eosinophil accumulation is a prominent feature of allergic inflammatory reactions, such as those occurring in the lung of the allergic asthmatic, but the endogenous chemoattractants involved have not been identified.
Airways Inflammation, P. Jose, D. Grif, P. Collins, D. Walsh, R. Moqbel, N. Totty, O. Truong, J. Hsuan, Timothy Williams   +9 more
semanticscholar   +1 more source