Results 21 to 30 of about 198,261 (297)

Correlation between eosinophil count, its genetic background and body mass index: The Nagahama Study

Allergology International, 2020
Background: Obesity affects the pathogenesis of various chronic diseases, including asthma. Research on correlations between obesity/BMI and eosinophilic inflammation in asthma has yielded contradictory results, which could be partly ascribed to the ...
Hironobu Sunadome, Hisako Matsumoto, Yumi Izuhara, Tadao Nagasaki, Yoshihiro Kanemitsu, Yumi Ishiyama, Chie Morimoto, Tsuyoshi Oguma, Isao Ito, Kimihiko Murase, Shigeo Muro, Takahisa Kawaguchi, Yasuharu Tabara, Kazuo Chin, Fumihiko Matsuda, Toyohiro Hirai   +15 more
doaj   +1 more source

Omalizumab effectiveness in patients with severe allergic asthma according to blood eosinophil count: the STELLAIR study

European Respiratory Journal, 2018
Omalizumab is a monoclonal anti-IgE antibody used to treat severe allergic asthma (SAA). The aim of the STELLAIR study was to determine the importance of pre-treatment blood eosinophil count as a predictive measure for response to omalizumab.
M. Humbert, C. Taillé, L. Mala, V. Le Gros, J. Just, M. Molimard   +5 more
semanticscholar   +1 more source

mTOR complexes differentially orchestrates eosinophil development in allergy

Scientific Reports, 2018
Eosinophil infiltration is considered a hallmark in allergic airway inflammation, and the blockade of eosinophil differentiation may be an effective approach for treating eosinophil-related disorders.
Chen Zhu, Lixia Xia, Fei Li, Lingren Zhou, Qingyu Weng, Zhouyang Li, Yinfang Wu, Yuanyuan Mao, Chao Zhang, Yanping Wu, Miao Li, Songmin Ying, Zhihua Chen, Huahao Shen, Wen Li   +14 more
doaj   +1 more source

Evaluation of exacerbations and blood eosinophils in UK and US COPD populations

Respiratory Research, 2019
Background Blood eosinophil counts and history of exacerbations have been proposed as predictors of patients with chronic obstructive pulmonary disease (COPD) who may benefit from triple therapy (inhaled corticosteroid, long-acting β2-agonist and long ...
Claus F. Vogelmeier, Konstantinos Kostikas, Juanzhi Fang, Hengfeng Tian, Bethan Jones, Christopher Ll Morgan, Robert Fogel, Florian S. Gutzwiller, Hui Cao   +8 more
doaj   +1 more source

Eosinophil may be a predictor of immune‐related adverse events induced by different immune checkpoint inhibitor types: A retrospective multidisciplinary study

Cancer Medicine, 2023
Background Immune checkpoint inhibitors (ICIs) can cause severe immune‐related adverse events (irAEs). However, biomarkers for irAEs common to different types of ICIs and cancers have not been reported. This study examined whether eosinophils can be used
Yoshihiko Tasaki, Yosuke Sugiyama, Shuzo Hamamoto, Taku Naiki, Takehiro Uemura, Keisuke Yokota, Daisuke Kawakita, Motoki Nakamura, Ryo Ogawa, Takaya Shimura, Yoshihisa Mimura, Yuji Hotta, Kunihiro Odagiri, Nanami Ito, Moeko Iida, Yuka Kimura, Hirokazu Komatsu, Hiromi Kataoka, Shuji Takiguchi, Akimichi Morita, Shinichi Iwasaki, Katsuhiro Okuda, Akio Niimi, Takahiro Yasui, Yoko Furukawa‐Hibi   +24 more
doaj   +1 more source

Natural killer cells induce eosinophil activation and apoptosis.

PLoS ONE, 2014
Eosinophils are potent inflammatory cells with numerous immune functions, including antigen presentation and exacerbation of inflammatory responses through their capacity to release a range of largely preformed cytokines and lipid mediators. Thus, timely
Ali Awad, Hanane Yassine, Mathieu Barrier, Han Vorng, Philippe Marquillies, Anne Tsicopoulos, Catherine Duez   +6 more
doaj   +1 more source

Metformin: A potential adjunct for treatment of systemic mastocytosis

Journal of Allergy and Clinical Immunology: Global
Background: Systemic mastocytosis (SM) is a clonal disorder of mast cells in which the KIT Asp816Val mutation can be detected not only in mature mast cells but also in the hematopoietic stem cell and in non–mast cell lineages.
Joseph H. Butterfield, MD, Kathleen Bartemes, PhD   +1 more
doaj   +1 more source

Esophageal Squamous Cell Carcinoma with Marked Eosinophil Infiltration

Case Reports in Gastroenterology, 2011
We report a case of esophageal squamous cell carcinoma (SCC) with marked eosinophil infiltration which was identified postoperatively in the esophageal wall in areas not surrounding the SCC.
Minoru Fukuchi, Shinji Sakurai, Masaki Suzuki, Hiroshi Naitoh, Yuichi Tabe, Takaharu Fukasawa, Shinsuke Kiriyama, Takehiko Yokobori, Hiroyuki Kuwano   +8 more
doaj   +1 more source

Prediction value of neutrophil and eosinophil count at risk of COPD exacerbation

Annals of Medicine, 2023
Introduction Predicting acute exacerbations (AEs) in chronic obstructive pulmonary disease (COPD) is crucial. This study aimed to identify blood biomarkers for predicting COPD exacerbations by inflammatory phenotypes.Materials and methods We analyzed ...
Tzu-Tao Chen, Kang-Yun Lee, Jer-Hwa Chang, Chi-Li Chung, Huan Minh Tran, Amja Manullang, Shu-Chuan Ho, Kuan-Yuan Chen, Chien-Hua Tseng, Sheng-Ming Wu, Hsiao-Chi Chuang   +10 more
doaj   +1 more source

Identification of autoantigens and their potential post-translational modification in EGPA and severe eosinophilic asthma

Frontiers in Immunology, 2023
BackgroundThe chronic airway inflammation in severe eosinophilic asthma (SEA) suggests potential autoimmune aetiology with unidentified autoantibodies analogous to myeloperoxidase (MPO) in ANCA-positive EGPA (eosinophilic granulomatosis with polyangiitis)
Ilaria Esposito, Ioanna Kontra, Chiara Giacomassi, Chiara Giacomassi, Sotiria Manou-Stathopoulou, James Brown, Richard Stratton, Richard Stratton, Galateia Verykokou, Roberto Buccafusca, Michael Stevens, Michael Stevens, Ahuva Nissim, Myles J. Lewis, Paul E. Pfeffer, Paul E. Pfeffer   +15 more
doaj   +1 more source