Prevalence of asthma and COPD and blood eosinophil count in a middle-aged Belgian population [PDF]
, 2019 Various phenotypes exist in asthma and Chronic Obstructive Pulmonary Disease (COPD). These are important to identify in order to guide treatment decisions.
Brusselle, Guy +4 more
core +1 more source
Advancing Eosinophilic Esophagitis Diagnosis and Phenotype Assessment with Deep Learning Computer Vision [PDF]
arXiv, 2021 Eosinophilic Esophagitis (EoE) is an inflammatory esophageal disease which is increasing in prevalence. The diagnostic gold-standard involves manual review of a patient's biopsy tissue sample by a clinical pathologist for the presence of 15 or greater eosinophils within a single high-power field (400x magnification).
arxiv
Eosinophil Apoptosis and Clearance in Asthma [PDF]
, 2013 Peer reviewedPublisher ...
Bickham U.R. +9 more
core +3 more sources
The reproducibility of COPD blood eosinophil counts
European Respiratory Journal, 2018 Post hoc and pre-specified analyses of chronic obstructive pulmonary disease (COPD) randomised controlled trials have shown that higher blood eosinophil counts predict greater inhaled corticosteroid (ICS) effects on exacerbation prevention [1–5].
T. Southworth +4 more
semanticscholar +1 more source
Inhalation Toxicity of Coal Fly Ash in Mice Models [PDF]
Asia Pacific Journal of Medical Toxicology, 2020 Background: Indonesia is one of world’s largest producers of coal. Coal fly ash (CFA), a product of the coal combustion process, consists of various minerals and causes toxic effects by inhalation.
Dewita Putri +2 more
doaj +1 more source
Uncertainty Quantification for Eosinophil Segmentation [PDF]
arXiv, 2023 Eosinophilic Esophagitis (EoE) is an allergic condition increasing in prevalence. To diagnose EoE, pathologists must find 15 or more eosinophils within a single high-power field (400X magnification). Determining whether or not a patient has EoE can be an arduous process and any medical imaging approaches used to assist diagnosis must consider both ...
arxiv
Regulation of eosinophilia and allergic airway inflammation by the glycan-binding protein galectin-1 [PDF]
, 2016 Galectin-1 (Gal-1), a glycan-binding protein with broad antiinflammatory activities, functions as a proresolving mediator in autoimmune and chronic inflammatory disorders. However, its role in allergic airway inflammation has not yet been elucidated.
Abramoff +15 more
core +1 more source
IL-33 Precedes IL-5 in Regulating Eosinophil Commitment and Is Required for Eosinophil Homeostasis
Journal of Immunology, 2016 Eosinophils are important in the pathogenesis of many diseases, including asthma, eosinophilic esophagitis, and eczema. Whereas IL-5 is crucial for supporting mature eosinophils (EoMs), the signals that support earlier eosinophil lineage events are less ...
L. Johnston +7 more
semanticscholar +1 more source
Dupilumab in persistent asthma with elevated eosinophil levels.
New England Journal of Medicine, 2013 BACKGROUND Moderate-to-severe asthma remains poorly treated. We evaluated the efficacy and safety of dupilumab (SAR231893/REGN668), a fully human monoclonal antibody to the alpha subunit of the interleukin-4 receptor, in patients with persistent ...
S. Wenzel +16 more
semanticscholar +2 more sources
Natural killer cells induce eosinophil activation and apoptosis.
PLoS ONE, 2014 Eosinophils are potent inflammatory cells with numerous immune functions, including antigen presentation and exacerbation of inflammatory responses through their capacity to release a range of largely preformed cytokines and lipid mediators. Thus, timely
Ali Awad +6 more
doaj +1 more source