Results 61 to 70 of about 24,045 (247)

Role of Adhesion Molecules in Eosinophil Activation: A Comparative Study on the Effect of Adhesion Molecules on Eosinophil Survival

Allergology International, 2004
Background: Adhesion molecules participate in an important part of inflammatory process in relation to the accumulation of inflammatory cells, such as eosinophils. The expression of adhesion molecules differs depending upon the cells and tissue.
Kazutoshi Yamaguchi, Shigeharu Ueki, Hajime Oyamada, Yumiko Kamada, Kazuyuki Hamada, Akira Kanda, Takahito Chiba, Hiroyuki Kayaba, Junichi Chihara   +8 more
doaj   +1 more source

Review on the correlation between chronic obstructive pulmonary disease and eosinophil in peripheral blood [PDF]

, 2021
Hongxiang Liu, Na Cui, Yifan Li
openalex   +1 more source

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, EarlyView.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

Protective Effects of Licochalcone A Improve Airway Hyper-Responsiveness and Oxidative Stress in a Mouse Model of Asthma

Cells, 2019
Licochalcone A was isolated from Glycyrrhiza uralensis and previously reported to have antitumor and anti-inflammatory effects. Licochalcone A has also been found to inhibit the levels of Th2-associated cytokines in the bronchoalveolar lavage fluid (BALF)
Wen-Chung Huang, Chien-Yu Liu, Szu-Chuan Shen, Li-Chen Chen, Kuo-Wei Yeh, Shih-Hai Liu, Chian-Jiun Liou   +6 more
doaj   +1 more source

Exploration of Novel Biomarkers Through a Precision Medicine Approach Using Multi‐Omics and Brain Organoids in Patients With Atypical Depression and Psychotic Symptoms

Advanced Science, EarlyView.
This study examines major depressive disorder with atypical features and psychotic symptoms through a multi‐omics precision medicine approach. By integrating clinical assessments, WBC scRNA‐seq, plasma proteomics, and brain organoid models, it uncovers immune dysregulation, synaptic protein alterations, and stress‐sensitive neuronal changes.
Insook Ahn, Soyeon Chang, Jiyoung Lee, Seok‐Ho Choi, Jinju Han, Yangsik Kim   +5 more
wiley   +1 more source

Clinical Utility of Machine Learning Methods Using Regression Models for Diagnosing Eosinophilic Chronic Rhinosinusitis

OTO Open
Objective Machine learning methods using regression models can predict actual values of histological eosinophil count from blood eosinophil levels. Therefore, these methods might be useful for diagnosing eosinophilic chronic rhinosinusitis, but their ...
Hiroatsu Hatsukawa, Masaaki Ishikawa
doaj   +1 more source

COPD patients prescribed inhaled corticosteroid in primary care – Time for re-assessment based on exacerbation rate and blood eosinophils? [PDF]

, 2021
Osman Savran, Nina Godtfredsen, Torben Lykke Sørensen, Christian S. Jensen, Charlotte Suppli Ulrik   +4 more
openalex   +1 more source

Eosinophil Depletion with Benralizumab for Eosinophilic Esophagitis

New England Journal of Medicine
Benralizumab is an eosinophil-depleting anti-interleukin-5 receptor α monoclonal antibody. The efficacy and safety of benralizumab in patients with eosinophilic esophagitis are unclear.In a phase 3, multicenter, double-blind, randomized, placebo-controlled trial, we assigned patients 12 to 65 years of age with symptomatic and histologically active ...
Marc E Rothenberg 1, Evan S Dellon 1, Margaret H Collins 1, Albert J Bredenoord 1, Ikuo Hirano 1, Kathryn A Peterson 1, Laura Brooks 1, Julie M Caldwell 1, Harald Fjällbrant 1, Hanna Grindebacke 1, Calvin N Ho 1, Matthew Keith 1, Christopher McCrae 1, Dominic Sinibaldi 1, Wendy I White 1, Catherine J Datto 1, MESSINA Trial Investigators: Fabio Almerigogna, Ignacio Antepara Ercoreca, Ana María Alonso Llamazares, Laurent Alric, Dhandapani Ashok, Kevin Bax, Lindsey McLeish, María Basagaña Torrentó, Amir Ben Tov, Adi Anafy, Dmitry S Bordin, Elen R Valitova, Albert J Bredenoord, M Laura Haasnoot, Aaltje Lei, Marco Caminati, Mirna Chehade, Constanza Ciriza de Los Ríos, Steven Clayton, Anca Mihaela Safta, Prerana Williamson, Elżbieta Czkwianianc, Wit Danilkiewicz, Nicola De Bortoli, Santino Marchi, Evan Dellon, Anjan Dhar, Rafael Firszt, Natalia Filipof, Ronald Fogel, Yasuhiro Fujiwara, Beata Gawdis-Wojnarska, Maciej Gonciarz, Nirmala Gonsalves, Frédéric Gottrand, Matthieu Antoine, Ian M Gralnek, Matthieu Groh, Catherine Nizou, Mar Guilarte Clavero, Laura Company-Sapiña, Ingrid Johana Gil, Paula Galván-Blasco, Thirumazhisai Gunasekaran, Jamal Hayat, Samantha Baillie, Attah Ocholi, Abigail Seward, Enrico Heffler, Alessandro Repici, Gaia Pellegatta, Francesca Racca, Navneet Hundal, Norihisa Ishimura, Eiko Okimoto, Anand S Jain, Halley Fowler, Maria Janiak, Jayaprakash Kamath, Showkat Hossain, Sergey Kashin, Jun Kato, Sibylle Koletzko, Hannes Leon, Tobias Schwerd, Bartosz Korczowski, Michał Korczowski, Natalya Krasnopeeva, Santhosh Kumar, Guillaume Lefevre, Jaroslaw Leszczyszyn, John Leung, Evan Cunningham, Joel Liem, Lindsay Douglas, Tracey Bondy, Delina Copland, Amanda Vieira, Maxime Luu, Kristle Lee Lynch, Jonathan Matz, François Mion, Sabine Roman, Ziva Mrevlje-Roman, Zdenka Cipinova, Rosa Muñoz-Cano, Gemma Lopez, Jason Ohayon, Sibgha Rehman, Vaidehi Bhatt, Gurnoor Walia, Robert Pesek, Erin Thomas, Safin Attwal, Kathryn Peterson, Amy Holman, Mohammed Mannan, Anupama Ravi, Imad Absah, Puanani Hopson, Yehuda Ringel, Marc Rothenberg, Kara Kliewer, Cristin Murray Petzold, Vincent Mukkada, Phil Putnam, Scott Bolton, Justin Schwartz, Pablo Abonia, Erinn Kellner, Ashley Devonshire, Frederick Ruthardt, Cecilio Santander Vaquero, Sergio Casabona Francés, Teresa Pérez Fernandez, Verónica Martin Domínguez, Pedro Majano Rodriguez, Francisca Molina Jiménez, Jennifer Fernandez Pacheco, Ellen Sher, Gary Gross, Jacqueline Ross, Ulyana Trytko, Peter Siersema, Dareen Siri, María Luisa Somoza Álvarez, Kathrin Sprinzl, Anna Stanziola, Miguel Stein, Robert Szalewski, Vinay Mehta, Alexander Trukhmanov, Vladimir Ivashkin, Tatiana Lapina, Toshio Uraoka, Christoph Schlag, Simon Weidlich, Jörg Ulrich, Bas Weusten, Phillip Woodland, William Yang, Patrizia Zentilin, Manuele Furnari, Elisabetta Giuliana, Giorgia Bodini, Elisa Marabotto, Frank Zerbib, Noam Zevit, Maciej Żymła   +164 more
openaire   +5 more sources

Bifurcate Regulation of Hematopoietic Homeostasis and Bone Osteogenesis by VHL‐HIF2α‐Controlled Adipocyte Function

Advanced Science, EarlyView.
The VHL‐HIF2α (VHL is Von Hippel‐Lindau) axis in adipocytes differentially regulates hematopoiesis and bone formation through stem cell factor (SCF) and chemerin, respectively. This hypoxia‐responsive pathway in adipocytes establishes a systemic signaling network with HSCs and MSCs to maintain tissue homeostasis, revealing a targetable axis for ...
Qian Li, Jia Li, Anshu Tang, Cong Li, Chao Zhang, Congcong Zhang, Yun‐Cai Liu   +6 more
wiley   +1 more source

Eosinophils in glioblastoma biology

Journal of Neuroinflammation, 2012
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. The development of this malignant glial lesion involves a multi-faceted process that results in a loss of genetic or epigenetic gene control, un-regulated cell growth, and ...
Curran Colleen S, Bertics Paul J
doaj   +1 more source