Results 131 to 140 of about 51,921 (307)

Olfactory Bulb Volume and Function Recovery in Eosinophilic Chronic Rhinosinusitis

The Laryngoscope, EarlyView.
This study investigated perioperative changes in olfactory bulb volume (OBV) in patients with eosinophilic chronic rhinosinusitis using high‐resolution 3T MRI. Postoperative increases in OBV were associated with improvements in olfactory identification, suggesting a potential link between olfactory bulb structural plasticity and functional recovery ...
Keisuke Yamamoto, Masaki Abukawa, Tsuyoshi Okuni, Mitsuhiro Nakanishi, Yuki Sakurai, Naoya Yama, Noriko Ogasawara, Ryuta Kamekura, Kenichi Takano   +8 more
wiley   +1 more source

Eosinophilic and Noneosinophilic Asthma [PDF]

American Journal of Respiratory and Critical Care Medicine, 2018
Tara F, Carr, Amir A, Zeki, Monica, Kraft   +2 more
openaire   +2 more sources

Corticosteroid Exposure in Chronic Rhinosinusitis and Global Airway Disease: Adrenal and Bone Impact

The Laryngoscope, EarlyView.
ABSTRACT Objective To investigate cumulative corticosteroid (CC) burden in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), with or without coexisting asthma (global airway disease, GAD), referred for biologic treatment, and to assess the prevalence of CC‐related comorbidities, including secondary adrenal insufficiency, osteopenia and ...
Christiane Haase, Kjell Erik Julius Håkansson, Peter Schwarz, Kasper Aanæs, Jens Tidemandsen, Charlotte Suppli. Ulrik, Bente Appel Esbensen, Vibeke Backer   +7 more
wiley   +1 more source

Neutrophilic asthma: current prospects. A review

Consilium Medicum
Asthma, caused by eosinophilic inflammation of the airways, is caused by exposure to allergen, is well treated with glucocorticostroids or monoclonal antibodies to interleukin-4 and 5, but some patients do not develop an answer to this therapy. The given
Viliya V. Gaynitdinova, Zamira M. Merzhoeva, Alena A. Aleksandrova   +2 more
doaj   +1 more source

Unique Features of Nasal Airway and Airflow Improvement Post‐Dupilumab: A Computational Cohort Study

The Laryngoscope, EarlyView.
The impact of dupilumab on nasal airway patency and airflow is not uniform. It is more pronounced in the middle and superior, but not inferior meatus. These unique regional changes significantly correlate with and potentially drive the improvement in patient symptoms.
Ahmad Odeh, Zhenxing Wu, Nidhi Jha, Aspen R. Schneller, James Mihalich, Zachary T. Root, Christopher Brooks, Casey Curtis, Monica Kraft, Kara Wada, Bradley A. Otto, Kathleen M. Kelly, Kai Zhao   +12 more
wiley   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

Differential Analysis of Hemogram Parameters and Cellular Ratios in Severe Asthma Exacerbations: A Comparative Study of Eosinophilic and Non-Eosinophilic Phenotypes

Life
Asthma exacerbations are acute worsening episodes in individuals with bronchial asthma, frequently necessitating emergency hospital care. Early differentiation between eosinophilic (≥150 eosinophils/mm3) and non-eosinophilic (
Nicolae Demenciuc, Corina Eugenia Budin, Corina Ureche, Mircea Stoian, Teodora Nicola-Varo, Dragos-Florin Baba, Dariana-Elena Pătrîntașu, Diana Deleanu   +7 more
doaj   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, EarlyView.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Differences in Type 2 Phenotype and Clinical Characteristics of Adult Asthma Patients with Different Severity, Across GINA Step 1 to 5 Asthma

Journal of Asthma and Allergy
Wang Chun Kwok, Julie Kwan Ling Wang, Terence Chi Chun Tam, James Chung Man Ho, David Chi Leung Lam, Mary Sau Man Ip Department of Medicine, the University of Hong Kong, Hong Kong, SAR, People’s Republic of ChinaCorrespondence: Mary Sau Man Ip ...
Kwok WC, Wang JKL, Tam TCC, Ho JCM, Lam DCL, Ip MSM   +5 more
doaj  

Effects of in vitro azithromycin treatment on bronchial epithelial antiviral immunity in asthma phenotypes

Frontiers in Allergy
BackgroundAzithromycin (AZM) effectively reduces asthma exacerbations and enhances bronchial epithelial cell (BEC) antiviral immunity in vitro. However, its clinical impact on different asthma phenotypes is not fully elucidated and differences in ...
Muzhda Ghanizada, Sofia Malm Tillgren, Louis Praeger-Jahnsen, Nihaya Mahmoud Said, Sisse Ditlev, Helle Frost Andreassen, Nanna Dyhre-Petersen, Samuel Cerps, Asger Sverrild, Celeste Porsbjerg, Lena Uller, Therese Lapperre, Therese Lapperre, Therese Lapperre, Mandy Menzel   +14 more
doaj   +1 more source