Results 241 to 250 of about 36,390 (302)

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, Volume 269, Issue 3, Page 268-283, July 2026.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Out of Breath, out of Options: Benralizumab as a Last Hope in ICU-Treated Near-Fatal Eosinophilic Asthma: A Case Series. [PDF]

Respirol Case Rep
Conemans L, Demir E, Bischoff M, Franssen F, Simons S.   +4 more
europepmc   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Consensus from European experts on severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps: Results from the OverSEA Delphi study. [PDF]

J Allergy Clin Immunol Glob
Bachert C, Brusselle G, Castillo Vizuete JA, Dávila I, Laudien M, Seccia V, Schmid-Grendelmeier P, Vultaggio A, Kallinikou K, Walrave L, Klimek L.   +10 more
europepmc   +1 more source

Longitudinal multi-trajectory phenotypes of severe eosinophilic asthma on type 2 biologics treatment. [PDF]

World Allergy Organ J
Pham DD, Lee JH, Kwon HS, Song WJ, Cho YS, Kim H, Kwon JW, Park SY, Kim S, Hur GY, Kim BK, Nam YH, Yang MS, Kim MY, Kim SH, Lee BJ, Lee T, Park SY, Kim MH, Cho YJ, Park C, Jung JW, Park HK, Kim JH, Moon JY, Bhavsar P, Adcock IM, Chung KF, Kim TB.   +28 more
europepmc   +1 more source

Autoimmune Mechanisms and Extracellular Traps in Non-eosinophilic Asthma. [PDF]

Allergy Asthma Immunol Res
Hur GY.
europepmc   +1 more source

Eosinophils in asthma.

Chinese medical journal, 2004
openaire   +1 more source

Mepolizumab: Which condition benefits more: Nasal polyps or eosinophilic asthma? [PDF]

Tuberk Toraks
Açar E, Köylüce S, Şeker S, Bozkurt Yilmaz HE, Aktaş Yapici E, Arslan B, Paçaci Çetin G, Türk M, Yilmaz İ.   +8 more
europepmc   +1 more source

Early and Sustained Response to Benralizumab in Severe, Eosinophilic Asthma: A Real-World Observational Study. [PDF]

J Asthma Allergy
Stolz D, Schuoler C, Charbonnier F, Bridevaux PO, Jandus P, Leuppi JD, Pavlov N, Piecyk A, Rothe T.   +8 more
europepmc   +1 more source