Results 221 to 230 of about 51,921 (307)

TNF Pathway‐Mediated Tolerogenic T‐Cell Trajectory Driven by Allergen Immunotherapy

Allergy, EarlyView.
The study shows that AIT re‐establishes local immune equilibrium by restoring Th17/Treg balance, while circulating Th17 cells remain functionally impaired. The transition from pro‐inflammatory Th17 to regulatory T cell states during AIT identifies Tr17 cells as an intermediate cell population.
Helen S. Charles, Amr A. Gabr, Shu‐Hung Wang, Ulrich M. Zissler, Sonja Heine, Alexander Heldner, Sebastian Kotz, Lisa Pechtold, Lynn S. zur Bonsen, Dimitrii Pogorelov, Josephine Kau, Mirjam Plaschke, Miriam Hills, Ferdinand Guerth, Madlen Oelsner, Caspar Ohnmacht, Francesca Alessandrini, Simon Blank, Adam M. Chaker, Carsten B. Schmidt‐Weber, Constanze A. Jakwerth   +20 more
wiley   +1 more source

Inflammation-induced loss of CFTR-expressing airway ionocytes in non-eosinophilic asthma. [PDF]

Respirology
Chen L, A Hoefel G, Pathinayake PS, Reid A, Pillar AL, Kelly C, Tan H, Ali A, Kim RY, Hansbro PM, Brody SL, Foster PS, Horvat JC, Riveros C, Awatade N, Wark PAB, Kaiko GE.   +16 more
europepmc   +1 more source

Staphylococcal enterotoxin B sensitization in eosinophilic asthma. [PDF]

Korean J Intern Med
Hur GY.
europepmc   +1 more source

Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?

British Journal of Pharmacology, EarlyView.
Psychedelic drugs that activate 5‐HT2A receptors have been long used for cultural, medicinal and recreational purposes. Interest in psychedelics for treating psychiatric disorders has resurged recently and is well documented; less well recognised are their anti‐inflammatory properties. Growing evidence now demonstrates that psychedelics modulate immune
Omar Qureshi, Jamie Cowley, Ashley Pegg, Alison J. Cooper, John Gordon, Catherine A. Brady, Antonio Belli, Sam Butterworth, Rachel Upthegrove, Nick Andrews, Nicholas M. Barnes   +10 more
wiley   +1 more source

SIRT5 Alleviated Eosinophilic Asthma Through ROS Inhibition and Nrf2/HO-1 Activation. [PDF]

Inflammation
Xie Y, He Y, Liang J, Liu J, Ke C, Mo X, Zeng C, Wang S, Chen X, Ao D, Tang J, Li W.   +11 more
europepmc   +1 more source

Safety, tolerability, pharmacokinetics and pharmacodynamics of the spleen tyrosine kinase inhibitor BI 894416 in healthy volunteers and patients with asthma

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Spleen tyrosine kinase (SYK) has broad biological functions in inflammation and immunity. The orally administered SYK inhibitor BI 894416 was investigated in a single‐rising‐dose Phase I study in healthy volunteers and in a combined single‐ and multiple‐rising‐dose Phase Ib study in patients with mild asthma ...
Saskia Carstensen‐Aurèche, Tobias Litzenburger, Dorothy De Sousa, Reinhard Sailer, Ewald Benediktus, Denis Delic, Fabian Müller, Meike Müller, Jens M. Hohlfeld   +8 more
wiley   +1 more source

Early and Sustained Clinical Benefits of Benralizumab in Severe Eosinophilic Asthma: Findings from the ORBE II Study. [PDF]

J Clin Med
Ausín P, Navarrete-Rouco ME, Carazo L, Sanchez-Trincado JL, Luzon E, Nuevo J, Santín M, Sánchez J, Padilla-Galo A.   +8 more
europepmc   +1 more source

The Effect of Mepolizumab on Blood Eosinophil Subtype Distribution and Granule Protein Gene Expression in Severe Eosinophilic Asthma. [PDF]

J Asthma Allergy
Rimkunas A, Januskevicius A, Vasyle E, Palacionyte J, Kalinauskaite-Zukauske V, Miliauskas S, Malakauskas K.   +6 more
europepmc   +1 more source