Parasympathetic Airway Hyperreactivity Is Enhanced in Acute but Not Chronic Eosinophilic Asthma Mouse Models. [PDF]
Pincus AB +6 more
europepmc +1 more source
Urinary Lipid Production Profile of Patients With Food Allergy
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 256-259, March 2025.
Sakura Masuko +10 more
wiley +1 more source
Impact of Biologics on Oscillometry Defined Small Airway Dysfunction in Uncontrolled Asthma
Forced oscillometry technique defined small airways dysfunction as a treatable trait in asthma. Monoclonal antibodies can improve small airways dysfunction, but their effects vary by mechanism of action. ABSTRACT Small airways dysfunction (SAD) is a recognised treatable trait within severe asthma, associated with worse symptom control and increased ...
Robert Greig +3 more
wiley +1 more source
Reduced IL-10 production by FoxP3+IL-10+ Treg cells is partially compensated by complosome-associated induction of regulatory FoxP3-IL-10+ T cells in allergic eosinophilic asthma. [PDF]
Stichova J +6 more
europepmc +1 more source
Eosinophils in Asthma and Airway Hyperresponsiveness
Christopher E. Brightling +5 more
openaire +2 more sources
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 264-266, March 2025.
Kirsten E. Stewart +3 more
wiley +1 more source
Abstract The landscape of asthma management is undergoing significant transformation. This change is driven by several factors: deeper understanding of asthma pathophysiology, appreciation of the long‐term harm of oral corticosteroids, biological treatments that dramatically improve patient outcomes with asthma remission becoming a realistic goal, and ...
John Politis +4 more
wiley +1 more source
Population Pharmacokinetics and Exposure-Response Analysis of Benralizumab in Chinese Adults, Adolescents, and Pediatric Participants with Severe Eosinophilic Asthma. [PDF]
Jin Y +9 more
europepmc +1 more source
Tissue Resident Memory Cells: Friend or Foe?
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude +2 more
wiley +1 more source
Benralizumab and the integrated management of co-morbid severe eosinophilic asthma with chronic rhinosinusitis with nasal polyps. [PDF]
Mullol J +4 more
europepmc +1 more source

