Results 191 to 200 of about 31,457 (263)

Staphylococcal enterotoxin B sensitization in eosinophilic asthma. [PDF]

Korean J Intern Med
Hur GY.
europepmc   +1 more source

The discovery and development of ensifentrine: A novel inhaled dual PDE3/4 inhibitor having ‘bifunctional’ bronchodilator and anti‐inflammatory activity

British Journal of Pharmacology, EarlyView.
Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley   +1 more source

Effects of azithromycin in severe eosinophilic asthma with concomitant monoclonal antibody treatment. [PDF]

Thorax
Lavoie G, Howell I, Melhorn J, Borg C, Bermejo-Sanchez L, Seymour J, Jabeen MF, Fries A, Hynes G, Pavord ID, Petousi N, Hinks TS.   +11 more
europepmc   +1 more source

Therapeutic potential of a Bax inhibitor‐1/TMBIM6 antagonist (BIA) and its analogues in Aspergillus fumigatus‐induced asthma via dual targeting of AKT and epithelial‐derived inflammatory cytokines

British Journal of Pharmacology, EarlyView.
Background and Purpose Aspergillus fumigatus (A. fumigatus) exposure causes of severe allergic asthma, characterized by airway inflammation and epithelial dysfunction. TMBIM6 (Bax inhibitor‐1) has been implicated in airway epithelial stress responses and AKT signalling.
Young‐Jin Yu, Ahsan Ullah, Jisun Kim, Mehedi Hasan Bappi, Yerim Heo, Jin Hee Ahn, Hyun‐Kyoung Kim, Han‐Jung Chae   +7 more
wiley   +1 more source

Inflammation-induced loss of CFTR-expressing airway ionocytes in non-eosinophilic asthma. [PDF]

Respirology
Chen L, A Hoefel G, Pathinayake PS, Reid A, Pillar AL, Kelly C, Tan H, Ali A, Kim RY, Hansbro PM, Brody SL, Foster PS, Horvat JC, Riveros C, Awatade N, Wark PAB, Kaiko GE.   +16 more
europepmc   +1 more source

The lung is more than an organ of gas exchange: immunocompetency, platelets and implications for drug discovery

British Journal of Pharmacology, EarlyView.
Abstract The lungs have for a long time been recognised as having pharmacological significance as a specific organ to modulate the pharmacokinetics of endogenous substances needed to maintain homeostasis. The lungs are therefore the site of action of certain drugs that act on these homeostatic processes, resulting in systemic effects on the ...
Simon C. Pitchford
wiley   +1 more source

SIRT5 Alleviated Eosinophilic Asthma Through ROS Inhibition and Nrf2/HO-1 Activation. [PDF]

Inflammation
Xie Y, He Y, Liang J, Liu J, Ke C, Mo X, Zeng C, Wang S, Chen X, Ao D, Tang J, Li W.   +11 more
europepmc   +1 more source

Eosinophilia Reflects Type 2 Immune Activation in Newly Diagnosed Bullous Pemphigoid, With No Evidence of Charcot‐Leyden Crystals

Allergy, EarlyView.
Janik Fleißner, Tassilo Dege, Sandrine Benoit, Matthias Goebeler, Andreas Kerstan   +4 more
wiley   +1 more source

Effect of the Arg16Gly β₂-Adrenergic Receptor Polymorphism on Long-Term Mepolizumab Response and Clinical Remission in Severe Eosinophilic Asthma: A Genotype-Stratified, Multicenter Study. [PDF]

Allergy
Nolasco S, Fagone E, Campisi R, Portacci A, Scioscia G, Pelaia C, Maglio A, Candia C, Quaranta VN, Carrieri I, Saglia A, Vatrella A, Pelaia G, Vancheri C, Foschino Barbaro MP, D'Amato M, Carpagnano GE, Crimi N, Crimi C, Southern Italy Network on Severe Asthma Therapy.   +19 more
europepmc   +1 more source