Results 191 to 200 of about 276,902 (250)

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

Recent Developments in Monoclonal-Antibody-Based Biologic Therapy for Severe Refractory Eosinophilic Asthma. [PDF]

Antibodies (Basel)
Walsh GM.
europepmc   +1 more source

Benralizumab in severe eosinophilic asthma: a comprehensive systematic review and meta-analysis of randomized controlled trials evaluating lung function, asthma control, and safety outcomes. [PDF]

Syst Rev
Al Mutair A, Alabbasi Y, Alharbi HF, Alyami H, Al-Shammari HM, Al-Omari AA, Bomozah EA, Aljarameez F, Daniyal M.   +8 more
europepmc   +1 more source

Functional respiratory imaging reveals early structural and functional airway responses to benralizumab in severe eosinophilic asthma. [PDF]

BMJ Open Respir Res
Conemans L, Deng Q, Simons SO, Franssen FME, Spruit MA, Hajian B.   +5 more
europepmc   +1 more source

Revisiting Platelet‐Activating Factor in Asthma: An Exploratory Metabolomics Analysis of PAF C‐18:1 and Type 2 Inflammation

Allergy, EarlyView.
Noeul Kang, Young Jin Pyung, Deog Kyeom Kim, Cheol‐Heui Yun, Hyun Woo Lee   +4 more
wiley   +1 more source

European Guidelines on Eosinophilic Esophagitis: Evidence‐Based Statements and Recommendations for Diagnosis and Management in Children and Adults. Part 1: Diagnosis, Epidemiology and Natural History

Allergy, EarlyView.
The European evidence‐based guidelines on eosinophilic esophagitis (Part 1). This infographic summarizes the methodological framework and core clinical outputs of the updated consensus developed by multidisciplinary experts from EUREOS, EAACI, ESPGHAN, and ESP.
Alfredo J. Lucendo, Javier Molina‐Infante, Ángel Arias, Ulrike von Arnim, Henrik Bergquist, Luc Biedermann, Albert J. Bredenoord, Marie Carlson, Javier Chahuan, Jorge Amil Dias, Thomas Eiwegger, Sara Feo‐Ortega, Sandra L. Garcia‐Dionisio, Matteo Ghisa, Jesús González‐Cervera, Thomas Greuter, Danila Guagnozzi, Carolina Gutiérrez‐Junquera, Lucía Gutiérrez‐Ramírez, Cord Langner, Helen Larsson, Anne Lund Krarup, Salvatore Oliva, Alexandra Papadopoulou, Francesca Racca, Cecilio Santander, Edoardo Vincenzo Savarino, Christoph Schlag, Alain M. Schoepfer, Martin A. Storr, Antonio Tejera‐Muñoz, Noam Zevit, Stephen E. Attwood, Alex Straumann   +33 more
wiley   +1 more source

Long-Term Adherence to Benralizumab and Sustained Clinical Benefits in Patients with Severe Eosinophilic Asthma: Insights from GALERNA, a Retrospective Real-World Study in Spain. [PDF]

J Clin Med
García-Moguel I, Agüero Calvo J, Betancor Pérez D, Carretero Gracia JÁ, Díaz-Campos RM, Fernández Martínez de Septien C, Gómez-Bastero Fernández A, Hernández Galván Y, Lloret-Queraltó JA, Lluch Tortajada I, Malanda NM, Martín-García C, Martínez Mesa Á, Martínez-Moragon E, Medina Gallardo JF, Padilla-Galo A, Pérez Chica G, Plasencia García I, Prieto Montaño P, Puchaes Manchón C, Romero Ribate D, Valverde-Monge M, Zamarro Parra MS, Sanchez-Trincado JL, Nuevo J, Luzon E, Velasco-Garrido JL.   +26 more
europepmc   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Local Delivery of a Bio‐Engineered IL‐37 Fc‐Fusion Ameliorates Experimental Allergic Asthma in Mice

Allergy, EarlyView.
Lars P. Lunding, Marcel F. Nold, Claudia A. Nold‐Petry, Michael Wegmann   +3 more
wiley   +1 more source