Results 171 to 180 of about 276,902 (250)

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean‐Christoph Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

IL-33 Modulates Cytotoxic NK Cell Subsets in Severe Eosinophilic Asthma. [PDF]

Life (Basel)
Bergantini L, Paggi I, Pianigiani T, Bargagli E, Cameli P.   +4 more
europepmc   +1 more source

Factors for Success and Failure of Allergen Immunotherapy (AIT) Trial Design in the Light of Evidence‐Based Medicine: Current Aspects 2026

Allergy, EarlyView.
ABSTRACT Allergen immunotherapy (AIT) has been acknowledged as the only disease‐modifying treatment for respiratory diseases since its introduction in 1911. Although the efficacy and safety have convincingly been established in numerous randomized clinical trials (RCTs), the AIT study results may vary substantially.
Roy Gerth van Wijk, Vera Mahler, Melanie Albrecht, Danilo di Bona, Benjamin Hofner, Jasper Kappen, Susanne Kaul, Graham Roberts, Mohamed H. Shamji, Stefan Vieths, Oliver Pfaar   +10 more
wiley   +1 more source

Mepolizumab Modifies Blood Eosinophil Proteome and Transcriptome in Severe Eosinophilic Asthma

Allergy, EarlyView.
This study investigates the effect of mepolizumab on the proteomic and transcriptomic profile of blood eosinophils in SEA patients. Mepolizumab reduces the migratory capacity and effector‐related molecular signatures of circulating eosinophils in SEA patients.
Pablo Miguéns‐Suárez, Sara Vázquez‐Mera, Laura Martelo‐Vidal, Marina Blanco Aparicio, Uxío Calvo Álvarez, Coral González Fernández, Mar Mosteiro Añón, Dolores Corbacho Abelaira, Tamara Hermida Valverde, Christian Calvo Henríquez, Susana B. Bravo, Lena Uller, Juan J. Nieto‐Fontarigo, Francisco J. Salgado, Francisco J. González‐Barcala   +14 more
wiley   +1 more source

Pulmonary Function in Adults with Severe Eosinophilic Asthma Using Biologicals:A Case-Control Study. [PDF]

Curr Health Sci J
Beserra ADS, Borges JR, Ferreira IDN, Santos MPC, Mafort TT, Bártholo TP, Lopes AJ.   +6 more
europepmc   +1 more source

Selective Absence of Co‐Inhibitory Receptor‐Expressing CD4+ T Cells in Lungs of Obese House Dust Mite‐Allergic C57BL/6 Mice

Allergy, EarlyView.
Obesity altered the inflammatory phenotype of HDM‐induced allergic airway inflammation in C57BL/6 mice, indicated by changed BAL cell composition. Single‐cell CITE‐Seq identified the lack of a CD4+ T‐cell subcluster characterized by co‐inhibitory receptor expression in obese HDM‐exposed C57BL/6 mice.
Sarah Miethe, Daniel P. Potaczek, Kim Pauck, Andrea Berlin, Bilal Alashkar Alhamwe, Stefanie Hagner, Andrea Nist, Elke Pogge von Strandmann, Thorsten Stiewe, Paul Klemm, Hartmann Raifer, Clemens Thölken, Holger Garn   +12 more
wiley   +1 more source

Comparative efficacy of mepolizumab and benralizumab in severe eosinophilic asthma: a retrospective cohort study. [PDF]

BMC Pulm Med
Huang WC, Shen YL, Cheng WC, Huang CW, Chen CH, Tu CY, Hsu WH.   +6 more
europepmc   +1 more source

Asthma Remission From Childhood to Young Adulthood–A Population‐Based Cohort Study

Allergy, EarlyView.
Among 257 participants with asthma at age 8 years, 39% achieved symptom‐based remission by age 24, 29% achieved clinical remission, and 18% achieved complete remission. Male sex increased the likelihood of symptom‐based remission, while food sensitization and overweight/obesity decreased the likelihood.
Lina Broström, Anna Bergström, Anne‐Sophie Merritt, Maria Ödling, Erik Melén, Inger Kull, Sandra Ekström   +6 more
wiley   +1 more source

Decoding the “Metallic” Immune Imprint: Single‐Cell Exposomics Reveals the Immune Imprint of Fire Smoke

Allergy, EarlyView.
Takafumi Kubota, Yuki Matsumoto, Takahiro Tabuchi   +2 more
wiley   +1 more source

Rademikibart for Asthma With Type 2 Biomarkers: Exploratory Subgroup Analyses From a Phase 2b Randomized Clinical Trial

Allergy, EarlyView.
This study reports exploratory and predominantly post hoc subgroup analyses, according to baseline eosinophil count and FeNO levels. In adults with moderate‐to‐severe uncontrolled asthma, rademikibart produced rapid and sustained improvements in lung function and asthma control.
Michael E. Wechsler, Praveen Akuthota, Barry Quart, Raúl Collazo   +3 more
wiley   +1 more source