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Hematopoietic Processes in Eosinophilic Asthma
Chest, 2017Airway eosinophilia is a hallmark of allergic asthma, and understanding mechanisms that promote increases in lung eosinophil numbers is important for effective pharmacotherapeutic development. It has become evident that expansion of hematopoietic compartments in the bone marrow (BM) promotes differentiation and trafficking of mature eosinophils to the ...
Brittany M, Salter, Roma, Sehmi
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Pentraxin levels in non‐eosinophilic versus eosinophilic asthma
Clinical & Experimental Allergy, 2018SummaryBackgroundInnate immunity has been thought to be involved in asthma pathogenesis. Pentraxins, acting as soluble pattern recognition molecules, play an important role in humoral innate immunity. Asthma is a heterogeneous inflammatory disease of airways and can be classified as eosinophilic or non‐eosinophilic asthma.ObjectiveTo investigate ...
Pengfei Gao +7 more
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Mepolizumab for severe eosinophilic asthma
Expert Review of Respiratory Medicine, 2013In this large (616 patients), double-blind, placebo-controlled, dose-ranging study of mepolizumab (a monoclonal antibody that blocks IL-5 binding to its receptor), patients were given placebo, 75-, 250- or 750-mg mepolizumab by intravenous infusion every 4 weeks for 1 year.
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Targeting of eosinophils in asthma
Expert Opinion on Biological Therapy, 2012Severe asthma continues to be an important source of morbidity despite the availability of bronchodilators and corticosteroids. Although new treatments are needed, better identification of asthma phenotypes may improve treatment effectiveness. One phenotype that has emerged is eosinophilic asthma. Eosinophils in asthma have been studied for many years,
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Eosinophil Activity in Bronchial Asthma
Allergy and Asthma Proceedings, 1994Eosinophil cationic proteins (ECP), eosinophil protein X (EPX), eosinophil peroxidase (EPO), eosinophil-derived neurotoxin (EDN), and the major basic protein (MBP) have been identified as potent cytotoxic secretory proteins in degranulated eosinophils.
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Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques, 1993
There has been continuing debate concerning the precise role of eosinophils. They appear to be an integral component in the pathogenesis of asthma, albeit their role has not as yet fully delineated.
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There has been continuing debate concerning the precise role of eosinophils. They appear to be an integral component in the pathogenesis of asthma, albeit their role has not as yet fully delineated.
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Comparative features of eosinophilic and non‐eosinophilic asthma
Clinical & Experimental Allergy, 2021Isabelle Xu +4 more
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Asthma phenotypes: the evolution from clinical to molecular approaches
Nature Medicine, 2012Sally E Wenzel
exaly