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Eosinophilic Endotype of Asthma
Immunology and Allergy Clinics of North America, 2016Asthma is a heterogeneous disease that can be classified into different clinical endotypes, depending on the type of airway inflammation, clinical severity, and response to treatment. This article focuses on the eosinophilic endotype of asthma, which is defined by the central role that eosinophils play in the pathophysiology of the condition.
Fernando, Aleman +2 more
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Eosinophils and Allergy in Asthma
Allergy and Asthma Proceedings, 1995Eosinophils are recruited to the site of IgE-mediated allergic reaction in the airway in asthma. Major eosinophil-chemotactic factors released from mast cells are platelet activating factor and Leukotriene B4. In addition, T cells and bronchial epithelial cells produce eosinophil chemotactic cytokines.
S, Makino, T, Fukuda
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The Role of the Eosinophil in Asthma
American Review of Respiratory Disease, 1991After the initial description of the histochemical characteristics of the eosinophil by Paul Erhlich in 1879 (1), recognition that this cell has associations with asthma was soon appreciated. Some of the earlier histopathologic descriptions of bronchial tissue from patients who had died from asthma contain vivid descriptions of the heavy eosinophil ...
S T, Holgate, W R, Roche, M K, Church
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Parasitology Today, 1990
Regulation of eosinophils in man mast cells and eosinophils (abstract only) control of eosinophil production immunoglobulin-mediated activation of eosinophils lipid metabolism by eosinophils role of eosinophils chemotactic factors on eosinophil activation and leukotriene C4 production eosinophil heterogeneity changes in the number of hypodense ...
J. Morley, I. Colditz
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Regulation of eosinophils in man mast cells and eosinophils (abstract only) control of eosinophil production immunoglobulin-mediated activation of eosinophils lipid metabolism by eosinophils role of eosinophils chemotactic factors on eosinophil activation and leukotriene C4 production eosinophil heterogeneity changes in the number of hypodense ...
J. Morley, I. Colditz
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The role of eosinophils in asthma
Lung, 1990During recent years it has become apparent that the eosinophil may represent a powerful effector cell in the pathogenesis of asthma, particularly in the late asthmatic response. It can be stimulated by a number of stimuli among which PAF appears to be one of the most effective.
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Targeting of eosinophils in asthma
Expert Opinion on Biological Therapy, 2012Severe asthma continues to be an important source of morbidity despite the availability of bronchodilators and corticosteroids. Although new treatments are needed, better identification of asthma phenotypes may improve treatment effectiveness. One phenotype that has emerged is eosinophilic asthma. Eosinophils in asthma have been studied for many years,
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New England Journal of Medicine, 1991
To the Editor: Bousquet et al. (Oct. 11 issue)1 and others2 2345 report that there is a general association between numbers of eosinophils and the severity of asthma. Unfortunately, the controls for their bronchial-biopsy data1 may not have been appropriate, since material obtained post mortem ...
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To the Editor: Bousquet et al. (Oct. 11 issue)1 and others2 2345 report that there is a general association between numbers of eosinophils and the severity of asthma. Unfortunately, the controls for their bronchial-biopsy data1 may not have been appropriate, since material obtained post mortem ...
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Eosinophils in exercise-induced asthma
Journal of Allergy and Clinical Immunology, 1991The variations in serum levels of eosinophil cationic protein (ECP) have been measured after exercise challenge of 13 patients with asthma with exercise-induced asthma (EIA) and nine patients with asthma without EIA. The patients were treated before exercise in a randomized and blinded fashion with inhalation of one dose of either disodium ...
P, Venge, J, Henriksen, R, Dahl
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2000
Bronchial hyperresponsiveness (BHR) to both specific and nonspecific stimuli is a characteristic feature of bronchial asthma. While the mechanisms underlying this exaggerated responsiveness are still unclear, there is a considerable body of evidence to suggest that mucosal inflammation of the airways is of central importance.
Anthony J. Coyle +1 more
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Bronchial hyperresponsiveness (BHR) to both specific and nonspecific stimuli is a characteristic feature of bronchial asthma. While the mechanisms underlying this exaggerated responsiveness are still unclear, there is a considerable body of evidence to suggest that mucosal inflammation of the airways is of central importance.
Anthony J. Coyle +1 more
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Annals of allergy, 1992
Eosinophils, a prominent feature of asthma, are found in increased numbers in the circulation and sputum, usually in relation to the severity of asthma. As a consequence of these clinical observations, investigators now speculate that the eosinophil has a central role in the pathogenesis of asthma.
W W, Busse, J B, Sedgwick
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Eosinophils, a prominent feature of asthma, are found in increased numbers in the circulation and sputum, usually in relation to the severity of asthma. As a consequence of these clinical observations, investigators now speculate that the eosinophil has a central role in the pathogenesis of asthma.
W W, Busse, J B, Sedgwick
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