Results 1 to 10 of about 136,090 (244)

Epigenetic and transcriptional programming of murine eosinophils in the esophagus [PDF]

Nature Communications
Eosinophils accumulate in different tissues in allergies, cancer, and infectious diseases, adopting distinct properties. Herein, we profiled murine esophageal eosinophils during allergic inflammation using single-cell sequencing, epigenomic mapping, and ...
Jennifer M. Felton, Lee E. Edsall, Ty D. Troutman, Lydia Mack, Michael Kotliar, Netali Ben-Baruch Morgenstern, Annalise M. Psaila, Mark Rochman, Andrea M. Klingler, Garrett A. Osswald, Simin Zhang, Julia L. M. Dunn, Ben Wronowski, Tetsuo Shoda, Julie M. Caldwell, Rana Herro, Artem Barski, Kate G. R. Quinlan, Matthew T. Weirauch, Marc E. Rothenberg   +19 more
doaj   +2 more sources

The multiple functions and subpopulations of eosinophils in tissues under steady-state and pathological conditions

Allergology International, 2021
Eosinophils not only play a critical role in the pathogenesis of eosinophil-associated diseases, but they also have multiple important biological functions, including the maintenance of homeostasis, host defense against infections, immune regulation ...
Akira Kanda, Yasutaka Yun, Dan Van Bui, Linh Manh Nguyen, Yoshiki Kobayashi, Kensuke Suzuki, Akitoshi Mitani, Shunsuke Sawada, Satoko Hamada, Mikiya Asako, Hiroshi Iwai   +10 more
doaj   +1 more source

Transcriptional Profiling of Mouse Eosinophils Identifies Distinct Gene Signatures Following Cellular Activation

Frontiers in Immunology, 2021
Eosinophils are multifunctional, evolutionary conserved leukocytes that are involved in a plethora of responses ranging from regulation of tissue homeostasis to host defense and cancer.
Avishay Dolitzky, Guy Shapira, Sharon Grisaru-Tal, Inbal Hazut, Shmulik Avlas, Yaara Gordon, Micahl Itan, Noam Shomron, Ariel Munitz   +8 more
doaj   +1 more source

Differential regulation of Type 1 and Type 2 mouse eosinophil activation by apoptotic cells

Frontiers in Immunology, 2022
Eosinophils are multifunctional, evolutionary conserved leukocytes that are involved in a plethora of responses ranging from regulation of tissue homeostasis, host defense and cancer. Although eosinophils have been studied mostly in the context of Type 2
Avishay Dolitzky, Inbal Hazut, Shmulik Avlas, Sharon Grisaru-Tal, Michal Itan, Ilan Zaffran, Francesca Levi-Schaffer, Motti Gerlic, Ariel Munitz   +8 more
doaj   +1 more source

Eosinophils: A Friend or Foe in human health and diseases

Kidney Diseases, 2022
Since their discovery, around 150 years, eosinophils research has been a field of changing perspective, and new directions are emerging since then. Initially, eosinophils were perceived as terminally-differentiated cytotoxic effector cells.
Madiha Zahra Syeda, Tu Hong, Chao Zhang, Songmin Ying, Huahao Shen   +4 more
doaj   +1 more source

Dermatomyositis with Eosinophils

Dermatopathology, 2023
Dermatomyositis is an idiopathic inflammatory myopathy that often presents with symmetric proximal skeletal muscle weakness and characteristic skin findings. Typical skin biopsy findings include vacuolar changes of the basal layer, increased dermal mucin,
Isabella I. Sanchez, Henry O. Herrera, Ashley Elsensohn, Bonnie A. Lee, Christina N. Kraus   +4 more
doaj   +1 more source

Eosinophils Decrease Pulmonary Metastatic Mammary Tumor Growth

Frontiers in Oncology, 2022
Metastatic breast cancer is challenging to effectively treat, highlighting the need for an improved understanding of host factors that influence metastatic tumor cell colonization and growth in distant tissues.
Rachel A. Cederberg, Rachel A. Cederberg, Sarah Elizabeth Franks, Brennan J. Wadsworth, Brennan J. Wadsworth, Alvina So, Lisa R. Decotret, Lisa R. Decotret, Michael G. Hall, Michael G. Hall, Rocky Shi, Rocky Shi, Michael R. Hughes, Kelly M. McNagny, Kelly M. McNagny, Kevin L. Bennewith, Kevin L. Bennewith, Kevin L. Bennewith   +17 more
doaj   +1 more source

Role of IL-25 on Eosinophils in the Initiation of Th2 Responses in Allergic Asthma

Frontiers in Immunology, 2022
BackgroundEosinophils act as a secondary antigen-presenting cell (APC) to stimulate Th cell responses against antigens. IL-25 plays a significant role in eosinophil activation in allergic asthma.
Bo Peng, Bo Peng, Bo Peng, Lin Sun, Lin Sun, Lin Sun, Meng Zhang, Huacheng Yan, Huacheng Yan, Huacheng Yan, Guochao Shi, Guochao Shi, Guochao Shi, Zhenwei Xia, Ranran Dai, Ranran Dai, Ranran Dai, Wei Tang, Wei Tang, Wei Tang   +19 more
doaj   +1 more source

CD44 on blood eosinophils as a novel marker of bronchial asthma management

Allergology International, 1998
Bronchial asthma (BA) is characterized by infiltration of the respiratory tracts by eosinophils. A wide variety of adhesion molecules is involved in the binding of eosinophils to the vascular endothelium and their subsequent transmigration from the ...
Kunio Sano, Kohei Yamauchi, Hiroki Hoshi, Masaaki Honma, Gen Tamura, Kunio Shirato   +5 more
doaj   +1 more source

Phosphodiesterase 4 inhibitors attenuate virus‐induced activation of eosinophils from asthmatics without affecting virus binding

Pharmacology Research & Perspectives, 2020
Acute respiratory virus infections, such as influenza and RSV, are predominant causes of asthma exacerbations. Eosinophils act as a double‐edged sword in exacerbations in that they are activated by viral infections but also can capture and inactivate ...
Yanaika Shari Sabogal Piñeros, Tamara Dekker, Barbara Smids, Christof J. Majoor, Lara Ravanetti, Gino Villetti, Maurizio Civelli, Fabrizio Facchinetti, René Lutter   +8 more
doaj   +1 more source