Results 171 to 180 of about 216,083 (239)

CCL26‐Mediated Modulation of Endothelial Secretome by Hypoxia‐Induced Tumor‐Derived Exosomes Enhances Metastatic Progression in Head and Neck Cancer

Head &Neck, EarlyView.
ABSTRACT Background Tumor cells adapt to hypoxia by releasing hiTDExs enriched with bioactive molecules that modulate endothelial behavior and promote tumor progression. This study aimed to characterize how hypoxia‐induced HNSCC exosomes reshape the endothelial secretome and contribute to metastatic potential.
Ozel Capik, Sevil Tekman, Betul Gundogdu, Ahsen Kilic, Rumeysa Polat, Omer Aydin, Omer Faruk Karatas   +6 more
wiley   +1 more source

Multidomain clinical and biological remission with tezepelumab in severe asthma: a 12-month multicentre real-world study. [PDF]

Respir Res
García-Rivero JL, Hannaoui Anaaoui A, Pallarés-Sanmartín A, Blanco-Aparicio M, García-Hernáez R, García-Gallardo Sanz V, Calvo-Álvarez U, Carazo-Fernández L, Hermida-Valverde T, Dorronsoro S, Carrascosa-Anguiano I, Lobato Astiárraga I, de Los Santos I, Enríquez-Rodríguez AI, Perez de Llano L, Álvarez Vega P, Abascal-Bolado B, Santibañez M.   +17 more
europepmc   +1 more source

Establishment of Salivary Gland Tumors Arising in Salivary Gland‐Specific EWSR1::ATF1 Transgenic Mice

Head &Neck, EarlyView.
ABSTRACT Background Salivary gland carcinomas are uncommon malignancies with various histological subtypes harboring fusion genes. The EWSR1::ATF1 fusion gene, resulting from a translocation between chromosomes 12 and 22, is frequently observed in hyalinizing clear cell carcinoma (HCCC). However, the role of this fusion gene in HCCC oncogenesis remains
Yuri Hirai, Yoshitaka Utsumi, Daisuke Sano, Tatsu Kuwahara, Yoshihiro Aizawa, Takashi Hatano, Hisashi Hasumi, Yutaro Soejima, Tatsukata Kawagoe, Ryosuke Jikuya, Nobuhisa Mizuki, Satoshi Fujii, Toshitaka Nagao, Nobuhiko Oridate   +13 more
wiley   +1 more source

Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils. [PDF]

Pediatr Allergy Immunol
Gautam R, Lal M, Carroll MC, Mrozek Z, Trachsel T, Beers J, Ruffner MA.   +6 more
europepmc   +1 more source

Eosinophilic Heart Disease: Pathophysiology, Diagnosis, and Management - A Narrative Review. [PDF]

Int J Gen Med
Dong J, Fu H, Wu N, Hu L, Du Y, Li H, Liu L.   +6 more
europepmc   +1 more source

Stratification of chronic rhinosinusitis with nasal polyps by distinct sinonasal microbial communities and their clinical and pathological correlations

iMetaOmics, EarlyView.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory condition. Dysbiosis is commonly observed. This study identified distinct sinonasal microbial communities in CRSwNP patients and explored their clinical and pathological associations. Two distinct microbial communities were identified: community type 1 (CT1), dominated by
Bixing Fang, Yanmin Liu, Qing Bao, Lin Sun, Hexin Chen, Qingxiang Meng, Linyi Jiao, Xiaoyan Ye, Jian Li, Tao Ding, Chunwei Li   +10 more
wiley   +1 more source

IL-1 delineates squalene-based adjuvant efficacy and reactogenicity in a cell-type-specific manner. [PDF]

NPJ Vaccines
Yoshioka Y, Nishinaka-Yoshioka A, Kobiyama K, Hayashi T, Kidani Y, Yanagida Y, Kasahara J, Tsujii K, Asaoka Y, Kuroda N, Kugimiya A, Osawa H, Yoshimura A, Onishi M, Nakagawa T, Ishida S, Omoto S, Nagira M, Coban C, Ishii KJ.   +19 more
europepmc   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Comment on: Eosinophilic granulomatosis with polyangiitis across the eosinophilic spectrum: from molecular mechanisms to practical differential diagnosis and targeted therapy. [PDF]

Reumatologia
Kosałka-Węgiel J, Korkosz M.
europepmc   +1 more source