Results 181 to 190 of about 216,083 (239)

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

IRF1 Is an upstream regulatory transcription factor of eosinophils in type 1 environments. [PDF]

J Allergy Clin Immunol
Nazaroff CD, Kienzl M, Schutte CA, LeSuer WE, Ochkur SI, Folmes CDL, Doyle AD, Wright BL, Rank MA, Krupnick A, Jacobsen EA.   +10 more
europepmc   +1 more source

Safety Assessment and Hypoglycemic Effect of Moringa oleifera Lam. Seed Lectin (WSMoL) in Alloxan‐Induced Diabetic Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos, Matheus Cavalcanti de Barros, Cleidiane Silva Vieira de Souza, Ryan Cristian da Silva, Luana Cassandra Breitenbach Barroso Coelho, Maria Tereza dos Santos Correia, Fernanda das Chagas Ângelo Mendes Tenório, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Robson Raion de Vasconcelos Alves, Patrícia Maria Guedes Paiva   +10 more
wiley   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

From esophagus to colon: A narrative review of eosinophilic gastrointestinal disorders. [PDF]

World J Gastrointest Pathophysiol
Qasim A, Zacharia GS, Veena F, Kandhi SD, Patel H.   +4 more
europepmc   +1 more source

Novel Laboratory Approaches in Heavy Chain Disease With Discordant Immunoglobulin Quantitation: A Case Report and Literature Review

Journal of Clinical Laboratory Analysis, EarlyView.
In this study, we investigated a rare case of γ‐heavy chain disease (γ‐HCD) through an integrated laboratory approach. Routine protein analyses (serum protein electrophoresis, immunotyping, and serum/urine immunofixation) identified an IgG monoclonal component without detectable light chains.
Eleonora Longhi, Artan Çeka, Fabiola Olivieri, Marco Moretti, Jacopo Sabbatinelli   +4 more
wiley   +1 more source

Standardisation of histologic reporting in eosinophilic oesophagitis: Expert recommendations. [PDF]

Pathologica
Giordano C, Angerilli V, Masci M, D'Armiento M, Parente P, Pilozzi E, Vanoli A, Oliva S, Savarino EV, Fassan M, Mastracci L.   +10 more
europepmc   +1 more source

The Application Value of Flow Cytometry‐Based Peripheral Blood Leukocyte Classification in Screening for Acute Leukemia and Posttreatment Monitoring

Journal of Clinical Laboratory Analysis, EarlyView.
Example of leukocyte classification results by FCM. The 16 cell populations are displayed in different colors according to the set gate logic. ABSTRACT Objective Assess the application value of flow cytometry (FCM) for peripheral blood leukocyte (PBL) classification in acute leukemia (AL) screening and monitoring.
Penghua Yan, Lianfeng Wu, Xiangyang Lin, Hong Lu, Jingjing Qian   +4 more
wiley   +1 more source

Profiling of rare immune cell populations and integrative analysis identify immune ecotypes in newly diagnosed meningiomas. [PDF]

Acta Neuropathol Commun
Lotsch C, Giuliani Canizales N, Jassowicz L, Rommel C, Barthel M, Lamszus K, Kessler AF, Grabe N, Loehr M, Ketter R, Senft C, Maas SLN, Sievers P, Westphal M, Simon M, von Deimling A, Unterberg A, Krieg SM, Sahm F, Warta R, Herold-Mende C.   +20 more
europepmc   +1 more source

Eosinophils unleashed

Blood, 2008
openaire   +3 more sources