Results 211 to 220 of about 24,553 (253)
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Establishment of Mouse Epiblast Stem Cells
2022Epiblast stem cells are made from the epiblast of mouse post-implantation embryo. They have been critical in the understanding of mammalian pluripotent stem cells as they share similar properties, such as their incapability to contribute to the formation of an embryo after injection into blastocyst.
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A fate map of the epiblast of the early chick embryo
Development, 1994ABSTRACT We have used carbocyanine dyes (DiI and DiO) to generate fate maps for the epiblast layer of the chick embryo between stage X and the early primitive streak stage (stages 2 –3). The overall distribution of presumptive cell types in these maps is similar to that described for other laboratory species (zebrafish ...
Y, Hatada, C D, Stern
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Reprogramming and Pluripotency of Epiblast Stem Cells
2012Pluripotent stem cells established in vitro from mammalian embryos are essential tools to understand pluripotency. From the mouse embryo, two kinds of stem cells can be derived, both being pluripotent: embryonic stem cells (ESCs) are derived from the pluripotent cells in the inner cell mass of the blastocyst, whereas epiblast stem cells (EpiSCs) are ...
Veillard, Anne-Clémence +2 more
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Modeling Human Epiblast Morphogenesis
2023The development of the human embryo is arguably the most complex process that we could care to study. In this process, the developing embryo must undergo proliferation, reorganization, lineage diversification, and dozens of cell fate specification events. During this time, a myriad of events are happening in parallel at the cell level, each one setting
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Avian primordial germ cells are of epiblastic origin
Development, 1981ABSTRACTWe have demonstrated that quail PGCs possess a characteristic heterochromatin nuclear marker demonstrable already at stage 6 H & H with Feulgen staining. Chimaeras of stage-XIII E. G & K. chick epiblast and quail hypoblast and vice versa have been made.
H, Eyal-Giladi, M, Ginsburg, A, Farbarov
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Heterogeneity in Epiblast Stem Cells
2019Epiblast stem cells (EpiSCs) are pluripotent cells that are derived from mouse embryos at gastrulation stages. They represent the primed state of pluripotency, in which cells are on the verge of differentiation and already express markers of the three primary lineages (mesoderm, endoderm, neurectoderm).
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Modeling Epiblast Shape in Implanting Mammalian Embryos
2022An indispensable prerequisite of mammalian development is successful morphogenesis in the epiblast, the embryonic tissue that gives rise to all differentiated cells of the adult mammal. The right control of both epiblast morphogenesis and the events that regulate its shape in particular during implantation is henceforth of tremendous importance ...
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Characterisation of bovine epiblast-derived outgrowth colonies
Reproduction, Fertility and Development, 2010The aim of the present study was to characterise bovine epiblast-derived outgrowth colonies (OCs) with respect to the embryonic origin of their cellular components. Epiblasts were isolated mechanically from bovine Day 12 embryos. Epiblasts were cultured on feeder layers of SNL cells (neomycin-resistant leukaemia inhibitory factor (LIF)-producing STO ...
Østrup, Esben +5 more
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Isolation and Culture of Pig Epiblast Stem Cells
2013Regulation of early development can be directly interrogated in the embryo or can be studied in cultured cells isolated in the laboratory. New understanding of the developmental stages and the signalling requirements of the pig embryo have enabled the development of improved protocols for the derivation of pluripotent cells from early epiblasts.
Aida, Rodriguez +2 more
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Direct reprogramming of fibroblasts into epiblast stem cells
Nature Cell Biology, 2010Epiblast stem cells (EpiSCs) derived from epiblast tissue of post-implantation embryos are pluripotent and can give rise to all three germ layers in teratoma assays. Introduction of the four transcription factors Oct4, Sox2, Klf4 and c-Myc into somatic cells has been shown to generate induced pluripotent stem cells (iPSCs) that are very similar to ...
Dong Wook, Han +8 more
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