Results 11 to 20 of about 220,016 (194)
Magnetic Iron Nanocubes Effectively Capture Epithelial and Mesenchymal Cancer Cells [PDF]
ACS Omega 2020, 5, 37, 23724 23735, 2020 Current methods for capturing circulating tumor cells (CTCs) are based on the overexpression of cytokeratin (CK) or epithelial cell-adhesion molecule (EpCAM) on cancer cells. However, during the process of metastasis, tumor cells undergo epithelial to mesenchymal transition (EMT) that can lead to the loss of CK/EpCAM expression.
arxiv +1 more source
Tumor Spheroid Chemotaxis in Epidermal Growth Factor Gradients Revealed by a 3D Microfluidic Device [PDF]
, 2021 Epidermal growth factor (EGF), a potent cytokine, is known to promote tumor invasion both in vivo and in vitro. Previously, we observed that single breast tumor cells (MDA-MB-231 cell line) embedded within a 3D collagen matrix displayed enhanced motility but no discernible chemotaxis in the presence of linear EGF gradients using a microfluidic platform.
arxiv +1 more source
Algebraic Model Selection and Experimental Design in Biological Data Science [PDF]
Advances in Applied Mathematics, 133 (2022), 2021 Design of experiments and model selection, though essential steps in data science, are usually viewed as unrelated processes in the study and analysis of biological networks. Not accounting for their inter-relatedness has the potential to introduce bias and increase the risk of missing salient features in the modeling process.
arxiv +1 more source
Tumor Biology, 2017 The finding of epidermal growth factor receptor tyrosine kinase inhibitors, which reflects a classical process of translational research, is a critical milestone for non-small-cell lung cancer treatment.
Shaohua Cui, Liyan Jiang
doaj +1 more source
Tumor Biology, 2017 Gallbladder cancer has poor prognosis and limited therapeutic options. Arctigenin, a representative dibenzylbutyrolactone lignan, occurs in a variety of plants.
Mingdi Zhang +11 more
doaj +1 more source
Balkan Medical Journal, 2017 Aims: Epidermal growth factor receptor mutation analysis in non-small cell lung cancer is important for selecting patients who will receive treatment with tyrosine kinase inhibitors.
Gaye Güler Tezel +3 more
doaj +1 more source
Epidermal growth factor receptor and KRAS mutations in Brazilian lung cancer patients
Clinics, 2012 OBJECTIVE: Epidermal growth factor receptor is involved in the pathogenesis of non-small cell lung cancer and has recently emerged as an important target for molecular therapeutics.
Carlos E. Bacchi +5 more
doaj +1 more source
Technology in Cancer Research & Treatment, 2020 Background: The efficacy of next-generation epidermal growth factor receptor-tyrosine kinase inhibitors in patients with advanced non-small cell lung cancer who have failed first-generation epidermal growth factor receptor-tyrosine kinase inhibitors ...
Yi-Tian Qi MM +2 more
doaj +1 more source
Technology in Cancer Research & Treatment, 2020 Background: To investigate the mechanism of microRNA9 in inhibiting proliferation and migration of lung squamous cell carcinoma cells via neuron-restricted silencing factor/epidermal growth factor receptor.
Kangning Wang MD +4 more
doaj +1 more source
BMC Medical Imaging, 2021 Background Human epidermal growth factor receptor2+ subtype breast cancer has a high degree of malignancy and a poor prognosis. The aim of this study is to develop a prediction model for the human epidermal growth factor receptor2+ subtype (non-luminal ...
Jin Zhou +9 more
doaj +1 more source