Results 21 to 30 of about 2,008,123 (283)
Nature Network Boston, 2016 Although mechanisms of acquired resistance of epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancers to EGFR inhibitors have been identified, little is known about how resistant clones evolve during drug therapy.
A. Hata +29 more
semanticscholar +1 more source
Epidermal growth factor as a biologic switch in hair growth cycle [PDF]
, 2002 The hair growth cycle consists of three stages known as the anagen (growing), catagen (involution), and telogen (resting) phases. This cyclical growth of hair is regulated by a diversity of growth factors.
Chan, SY, Mak, KKL
core +1 more source
Tumor Biology, 2017 The use of trastuzumab in patients with breast cancer that overexpresses human epidermal growth factor receptor 2 has significantly improved treatment outcomes.
Marianne Nordlund Broughton +6 more
doaj +1 more source
Inhibiting epidermal growth factor receptor at a distance. [PDF]
, 2014 The epidermal growth factor receptor (EGFR) tyrosine kinase is implicated in a large number of human cancers. Most EGFR inhibitors target the extracellular, growth factor-binding domain or the intracellular, ATP-binding domain. Here we describe molecules
Denton, Elizabeth +2 more
core +2 more sources
Epidermal growth factor in the oesophagus. [PDF]
Gut, 1992 Epidermal growth factor (EGF) has been implicated in mitogenesis and oncogenesis in the gastrointestinal tract. To determine the role of EGF in oesophageal disease, its quantity and distribution in the oesophageal mucosa of control subjects and patients with oesophageal disease were studied.
K. G. Wormsley +4 more
openaire +2 more sources
Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. [PDF]
, 2019 BACKGROUND:The Human Epidermal Growth Factor Receptor (EGFR/HER1) can be activated by several ligands including Transforming Growth Factor alpha (TGF-α) and Epidermal Growth Factor (EGF).
Dutta, Pranabananda +5 more
core +5 more sources
Tumor Biology, 1990 The article is a review of recent knowledge of the structural relationships of epidermal growth factor (EGF) with other biological products occurring in a wide range of animal species and some viruses. The place of EGF and related products in the physiology of the whole organism is discussed against this background.
D.J.R. Laurence, B.A. Gusterson
openaire +2 more sources
Targeting the EGFR in ovarian cancer with the tyrosine kinase inhibitor ZD1839 (“Iressa”). [PDF]
, 2002 The modulating effects of the orally active epidermal growth factor receptor-specific tyrosine kinase inhibitor ZD 1839 (‘Iressa’) on cell growth and signalling were evaluated in four ovarian cancer cell lines (PE01, PE04, SKOV-3, OVCAR-5) that express ...
A Berchuck +29 more
core +2 more sources
Differential activity of 2-methylene-19-nor vitamin D analogs on growth factor gene expression in rhino mouse skin and comparison to all-trans retinoic acid. [PDF]
PLoS ONE, 2017 While all 2-methylene-19-nor analogs of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) tested produce an increase in epidermal thickness in the rhino mouse, only a subset reduce utricle size (comedolysis).
Jamie M Ahrens +5 more
doaj +1 more source
The urine as a diagnostic key for a homozygous EGFR mutation [PDF]
Revista Portuguesa de Nefrologia e Hipertensão, 2022 Primary inherited epidermal growth factor receptor defects have recently been described in severe inflammatory skin disease and diarrhoea case reports. We describe two case reports of female preterm newborns of Roma consanguineous parents who presented ...
Mafalda Casinhas Santos +4 more
doaj +1 more source