Results 31 to 40 of about 485,092 (339)

Single-domain antibodies for radio nuclear imaging and therapy of esophageal squamous cell carcinoma: a narrative review

Journal of Bio-X Research, 2020
. Single-domain antibodies have the characteristics of small molecular weight, strong tissue penetration, and high affinity, and are widely used to construct molecular probes for disease diagnosis and treatment.
Huifang Liu, Xu Nie, Zhenchao Tian, Dan Chen, Xueli Chen, Qi Zeng, Xinyi Xu   +6 more
doaj   +1 more source

Preferential human epidermal growth factor receptor 2 expression in myometrial and lymphovascular invasion of a uterine carcinosarcoma: A case report

SAGE Open Medical Case Reports, 2022
This case report describes a unique pattern of human epidermal growth factor receptor 2 expression in a patient with uterine carcinosarcoma. The endometrial tumor showed biphasic morphology composed of serous carcinoma and a heterologous high-grade ...
Joseph Gillam, Raghavendra Pillappa, Michael Idowu, Cecelia Boardman, Stephanie A Sullivan, Sadia Sayeed   +5 more
doaj   +1 more source

The effect of distant metastases sites on survival in de novo stage-IV breast cancer: A SEER database analysis

Tumor Biology, 2017
To investigate the effect of distant metastases sites on survival in patients with de novo stage-IV breast cancer. From 2010 to 2013, patients with a diagnosis of de novo stage-IV breast cancer were identified using the Surveillance, Epidemiology, and ...
San-Gang Wu, Hui Li, Li-Ying Tang, Jia-Yuan Sun, Wen-Wen Zhang, Feng-Yan Li, Yong-Xiong Chen, Zhen-Yu He   +7 more
doaj   +1 more source

The investigation of the amounts and expressions of epidermal growth factor, epidermal growth factor receptor, and epidermal growth factor receptor gene polymorphisms in acne vulgaris

Journal of Cosmetic Dermatology, 2020
AbstractBackgroundEpidermal growth factor receptor inhibitors (EGFRI) used in cancer chemotherapy cause acneiform folliculitis in 70%‐100% of patients in a dose‐dependent manner. Acneiform folliculitis is considered to be caused by an inflammatory process due to follicular hyperkeratosis and subsequently a set of changes both in epidermis and hair ...
Ikbal Esen Aydingoz, Gulsen Tukenmez Demirci, Deniz Agirbasli, Devrim Oz‐Arslan, Guven Yenmis   +4 more
openaire   +5 more sources

Epidermal Growth Factor Receptor Dynamics Influences Response to Epidermal Growth Factor Receptor Targeted Agents [PDF]

Cancer Research, 2005
Abstract Analysis of gene expression of cancer cell lines exposed to erlotinib, a small molecule inhibitor of the epidermal growth factor receptor (EGFR), showed a marked increase in EGFR mRNA in resistant cell lines but not in susceptible ones.
Maria L. Amador, Antonio Jimeno, Nadia Bouraoud, Anirban Maitra, Belen Rubio-Viqueira, D. Oppenheimer, Peter Kulesza, Valeria Sebastiani, Manuel Hidalgo   +8 more
openaire   +2 more sources

Differential activity of 2-methylene-19-nor vitamin D analogs on growth factor gene expression in rhino mouse skin and comparison to all-trans retinoic acid. [PDF]

PLoS ONE, 2017
While all 2-methylene-19-nor analogs of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) tested produce an increase in epidermal thickness in the rhino mouse, only a subset reduce utricle size (comedolysis).
Jamie M Ahrens, James D Jones, Nirca J Nieves, Ann M Mitzey, Hector F DeLuca, Margaret Clagett-Dame   +5 more
doaj   +1 more source

Epidermal Growth Factor Receptor in Pancreatic Cancer [PDF]

Cancers, 2011
Pancreatic cancer is the fourth leading cause of cancer related death. The difficulty in detecting pancreatic cancer at an early stage, aggressiveness and the lack of effective therapy all contribute to the high mortality. Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein, which is expressed in normal human tissues. It is a member
Melissa Oliveira-Cunha, Ajith K. Siriwardena, William G. Newman   +2 more
openaire   +3 more sources

EGFR (Epidermal Growth Factor Receptor) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2020
ERBB family member epidermal receptor tyrosine kinase (EGFR) is composed of 28 exons and 27 introns. EGFR codes for 11 transcripts and 8 of them are protein coding. EGFR is a transmembrane glycoprotein that can be activated by several different ligands such as epidermal growth factor (EGF), transforming growth factor-alpha (TGFA), heparin-binding EGF ...
Hatil, Ayca Circir, Cicek, Esra, Oyken, Merve, Erson-Bensan, A Elif   +3 more
openaire   +3 more sources

Homologous Control of Protein Signaling Networks [PDF]

Journal of Theoretical Biology 279 (2011) 29-43, 2010
In a previous paper we introduced a method called augmented sparse reconstruction (ASR) that identifies links among nodes of ordinary differential equation networks, given a small set of observed trajectories with various initial conditions. The main purpose of that technique was to reconstruct intracellular protein signaling networks. In this paper we
arxiv   +1 more source

Individual participant data from digital sources informed and improved precision in the evaluation of predictive biomarkers in Bayesian network meta-analysis [PDF]

arXiv, 2023
Objective: We aimed to develop a meta-analytic model for evaluation of predictive biomarkers and targeted therapies, utilising data from digital sources when individual participant data (IPD) from randomised controlled trials (RCTs) are unavailable. Methods: A Bayesian network meta-regression model, combining aggregate data (AD) from RCTs and IPD ...
arxiv