Results 51 to 60 of about 978,913 (425)

Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer.

Journal of the National Cancer Institute, 2005
BACKGROUND Gefitinib is a selective inhibitor of the epidermal growth factor (EGFR) tyrosine kinase, which is overexpressed in many cancers, including non-small-cell lung cancer (NSCLC). We carried out a clinical study to compare the relationship between
F. Cappuzzo, F. Hirsch, E. Rossi, S. Bartolini, G. Ceresoli, L. Bemis, J. Haney, S. Witta, K. Danenberg, I. Domenichini, V. Ludovini, E. Magrini, V. Gregorc, C. Doglioni, A. Sidoni, M. Tonato, W. Franklin, L. Crinò, P. Bunn, M. Varella-Garcia   +19 more
semanticscholar   +1 more source

Single-domain antibodies for radio nuclear imaging and therapy of esophageal squamous cell carcinoma: a narrative review

Journal of Bio-X Research, 2020
. Single-domain antibodies have the characteristics of small molecular weight, strong tissue penetration, and high affinity, and are widely used to construct molecular probes for disease diagnosis and treatment.
Huifang Liu, Xu Nie, Zhenchao Tian, Dan Chen, Xueli Chen, Qi Zeng, Xinyi Xu   +6 more
doaj   +1 more source

Human Epidermal Growth Factor Receptor 2 (HER2) in Cancers: Overexpression and Therapeutic Implications

Molecular Biology International, 2014
Human epidermal growth factor receptor 2 (HER2) is a member of the epidermal growth factor receptor family having tyrosine kinase activity. Dimerization of the receptor results in the autophosphorylation of tyrosine residues within the cytoplasmic domain
N. Iqbal, N. Iqbal
semanticscholar   +1 more source

Preferential human epidermal growth factor receptor 2 expression in myometrial and lymphovascular invasion of a uterine carcinosarcoma: A case report

SAGE Open Medical Case Reports, 2022
This case report describes a unique pattern of human epidermal growth factor receptor 2 expression in a patient with uterine carcinosarcoma. The endometrial tumor showed biphasic morphology composed of serous carcinoma and a heterologous high-grade ...
Joseph Gillam, Raghavendra Pillappa, Michael Idowu, Cecelia Boardman, Stephanie A Sullivan, Sadia Sayeed   +5 more
doaj   +1 more source

Bystander killing effect of DS‐8201a, a novel anti‐human epidermal growth factor receptor 2 antibody–drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity

Cancer Science, 2016
Antibody–drug conjugates deliver anticancer agents selectively and efficiently to tumor tissue and have significant antitumor efficacy with a wide therapeutic window.
Y. Ogitani, K. Hagihara, Masataka Oitate, H. Naito, T. Agatsuma   +4 more
semanticscholar   +1 more source

Immunohistochemical Expression of Epidermal Growth Factor Receptor in Astrocytic Tumors in Iraqi Patients [PDF]

, 2019
BACKGROUND: Diffuse astrocytomas constitute the largest group of primary malignant human intracranial tumours. They are classified by the World Health Organization (WHO) into three histological malignancy grades: diffuse astrocytomas (grade II ...
Abbas, Mohamad Natiq, Abdulghani, Mohanad Mundher, Mohammed, Wafaa Redha   +2 more
core   +2 more sources

Epidermal Growth Factor Receptor Dynamics Influences Response to Epidermal Growth Factor Receptor Targeted Agents [PDF]

Cancer Research, 2005
Abstract Analysis of gene expression of cancer cell lines exposed to erlotinib, a small molecule inhibitor of the epidermal growth factor receptor (EGFR), showed a marked increase in EGFR mRNA in resistant cell lines but not in susceptible ones.
Maria L. Amador, Antonio Jimeno, Nadia Bouraoud, Anirban Maitra, Belen Rubio-Viqueira, D. Oppenheimer, Peter Kulesza, Valeria Sebastiani, Manuel Hidalgo   +8 more
openaire   +2 more sources

Epidermal growth factor receptor (EGFR) and EGFRvIII in glioblastoma (GBM): signaling pathways and targeted therapies

Oncogene, 2017
Amplification of epidermal growth factor receptor (EGFR) and its active mutant EGFRvIII occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in pathogenesis, targeted therapy with EGFR-tyrosine kinase inhibitors (TKIs) or ...
Zhenyi An, O. Aksoy, Tina Zheng, Q. Fan, W. Weiss   +4 more
semanticscholar   +1 more source

Soluble Epidermal Growth Factor Receptor

Definitions, 2020
Soluble epidermal growth factor receptor is encoded by the human EGFR gene. This protein may be involved in the regulation of epidermal growth factor receptor signaling.

semanticscholar   +1 more source

The effect of distant metastases sites on survival in de novo stage-IV breast cancer: A SEER database analysis

Tumor Biology, 2017
To investigate the effect of distant metastases sites on survival in patients with de novo stage-IV breast cancer. From 2010 to 2013, patients with a diagnosis of de novo stage-IV breast cancer were identified using the Surveillance, Epidemiology, and ...
San-Gang Wu, Hui Li, Li-Ying Tang, Jia-Yuan Sun, Wen-Wen Zhang, Feng-Yan Li, Yong-Xiong Chen, Zhen-Yu He   +7 more
doaj   +1 more source