A structural perspective on the regulation of the epidermal growth factor receptor.
Annual Review of Biochemistry, 2015 The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that plays a critical role in the pathogenesis of many cancers. The structure of intact forms of this receptor has yet to be determined, but intense investigations of fragments of ...
E. Kovács +4 more
semanticscholar +1 more source
Statistical physics approaches to subnetwork dynamics in biochemical systems [PDF]
, 2016 We apply a Gaussian variational approximation to model reduction in large biochemical networks of unary and binary reactions. We focus on a small subset of variables (subnetwork) of interest, e.g. because they are accessible experimentally, embedded in a larger network (bulk).
arxiv +1 more source
Keratinocyte stimulation of matrix metalloproteinase-1 production and proliferation in fibroblasts: regulation through mitogen-activated protein kinase signalling events [PDF]
Incubation of human dermal fibroblasts in keratinocyte-conditioned culture medium led to a 5.7-fold increase in the level of matrix metalloproteinase-1.
Bhagavathula, N, Moon, S E, Varani, J
core +2 more sources
Regulation of human cardiac KCNQ1/KCNE1 channel by epidermal growth factor receptor kinase [PDF]
, 2010 The aim of the present study was to investigate whether/how the recombinant human cardiac I Ks could be regulated by epidermal growth factor receptor kinase in HEK 293 cells stably expressing hKCNQ1/hKCNE1 genes using the approaches of perforated patch ...
Dong, MQ +5 more
core +1 more source
Epidermal growth factor receptor: Role in human cancer
Indian Journal of Dental Research, 2017 Cells are constantly exposed to various external stimuli which regulate the growth and survival of the cells. The signal transduction from the external environment to the interior of the cell is carried out by cell surface or transmembrane receptors ...
P. Chandra +5 more
semanticscholar +1 more source
Epidermal growth factor receptor-regulated miR-125a-5p – a metastatic inhibitor of lung cancer [PDF]
Both the epidermal growth factor receptor signaling pathway and microRNA (miRNA) play an important role in lung cancer development and progression. To address the potential role of miRNA in epidermal growth factor receptor signaling, we identified miR ...
Amann +20 more
core +2 more sources
Cortactin overexpression results in sustained epidermal growth factor receptor signaling by preventing ligand-induced receptor degradation in human carcinoma cells [PDF]
, 2005 The chromosome 11q13 region is frequently amplified in human carcinomas and results in an increased expression of various genes including cortactin, and is also associated with an increased invasive potential.
A Nadal +28 more
core +2 more sources
The Effects of EGF-Receptor Density on Multiscale Tumor Growth Patterns [PDF]
arXiv, 2005 We studied the effects of epidermal growth factor receptor (EGFR) density on tumor growth dynamics, both on the sub- and the multi-cellular level using our previously developed model. This algorithm simulates the growth of a brain tumor using a multi-scale two-dimensional agent-based approach with an integrated transforming growth factor alpha ...
arxiv
Journal of Biological Chemistry, 1991 Madin-Darby canine kidney (MDCK) cells polarize and generate distinct apical and basolateral membrane domains when grown on permeable filter supports. Under these conditions, they transcytose fluid-phase markers. Recently, receptor-mediated transcytosis of epidermal growth factor (EGF) across MDCK cells has been reported (Maratos-Flier, E., Kao, C.-Y ...
Kai Simons, E D Adamson, A W Brändli
openaire +3 more sources
The relationship between the L1 and L2 domains of the insulin and epidermal growth factor receptors and leucine-rich repeat modules [PDF]
, 2001 BACKGROUND: Leucine-rich repeats are one of the more common modules found in proteins. The leucine-rich repeat consensus motif is LxxLxLxxNxLxxLxxLxxLxx- where the first 11–12 residues are highly conserved and the remainder of the repeat can vary in size
Garrett, Thomas PJ, Ward, Colin W
core +2 more sources