Results 61 to 70 of about 809,825 (355)

Skin Toxicities Induced by Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and their Influence on Treatment Adjustments in Lung Cancer Patients

Acta Dermato-Venereologica
Skin toxicities caused by epidermal growth factor receptor tyrosine kinase inhibitors can affect patient quality of life and lead to treatment adjustments, including dose reduction or discontinuation.
Ji Su Lee, Jimin Woo, Tae Min Kim, Namkyu Kim, Bhumsuk Keam, Seong Jin Jo   +5 more
doaj   +1 more source

Cicatricial ectropion and madarosis associated with panitumumab treatment of metastatic colorectal cancer

American Journal of Ophthalmology Case Reports, 2020
Purpose: To report a case of cicatricial ectropion and madarosis with the use of anti-epidermal growth factor receptor medication panitumumab. Observations: An 82-year-old man with metastatic colorectal cancer presented with cicatricial ectropion and ...
Haoxing D. Jin, Nathan W. Blessing
doaj   +1 more source

Epidermal growth factor receptor in glioblastoma

Oncology Letters, 2017
Mutations in the epidermal growth factor receptor (EGFR) are commonly occurring in glioblastoma. Enhanced activation of EGFR can occur through a variety of different mechanisms, both ligand-dependent and ligand-independent.
Hongsheng Xu, Hailiang Zong, Chong Ma, Xing Ming, M. Shang, Kai Li, Xiaoguang He, Hai Du, Lei Cao   +8 more
semanticscholar   +1 more source

MKP1 mediates resistance to therapy in HER2-positive breast tumors. [PDF]

, 2015
Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that is overexpressed in many cancers, including breast cancer.
Candas, Demet, Li, Jian Jian
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Case report: Concomitant EGFR mutation and ALK rearrangement in non-small cell lung cancer

Frontiers in Pharmacology, 2023
In non-small cell lung cancer (NSCLC), two key genetic alterations, epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements, are commonly believed to be mutually exclusive.
Haoyue Hu, Songtao Tan, Songtao Tan, Meng Xie, Peng Guo, Qiang Yu, Qiang Yu, Juan Xiao, Kangrui Zhao, Qiong Liao, Yi Wang   +10 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Radiotherapy and erlotinib combined: review of the preclinical and clinical evidence

Frontiers in Oncology, 2012
Epidermal growth factor receptor is often overexpressed in tumors and has been associated with poor prognosis in some cancer types. The introduction of inhibitors of epidermal growth factor receptor, such as erlotinib and cetuximab, represents an ...
Vivek Krishan Mehta
doaj   +1 more source

Comparison of melatonin with growth factors in promoting precursor cells proliferation in adult mouse subventricular zone [PDF]

, 2016
Melatonin, secreted mainly by the pineal gland, plays roles in various physiological functions including protecting cell death. We showed in previous study that the proliferation and differentiation of precursor cells from the adult mouse subventricular ...
Ekthuwapranee, Kasima, Govitrapong, Piyarat, Sotthibundhu, Areechun   +2 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source