Results 91 to 100 of about 5,980,424 (294)

ZFP42 maintains stemness and rhythmic transcription in human epidermal stem and progenitor cells via CRY1

Communications Biology
The role of circadian rhythm in regulating stemness in adult stem cells remains unclear. We investigated this in human epidermal stem and progenitor cells (EPSCs), finding that ~10% of expressed genes exhibit rhythmicity, with shared genes between fetal ...
Shuiying Gao, Hao Tan, Shuqia Xu, Zhaoyu Zhang, Yushuang Sun, Yaqiong Li, Dan Jian, Xiaowen Qi, Qing Tang, Run Chen, Dongyu Wang, Miao Zhen, Peng Wang, Bin Shu, Jingting Li   +14 more
doaj   +1 more source

Niche-independent symmetrical self-renewal of a mammalian tissue stem cell. [PDF]

, 2005
Pluripotent mouse embryonic stem (ES) cells multiply in simple monoculture by symmetrical divisions. In vivo, however, stem cells are generally thought to depend on specialised cellular microenvironments and to undergo predominantly asymmetric divisions.
Luciano Conti, Thorsten Gorba (59561), Mauro Toselli, Biella, G, Sanzone Sveva, Toselli, M, Austin Smith, Reitano Erika, Reitano, E, T. Gorba, Smith Austin, Steven M Pollard, E. Reitano, Sveva Sanzone (59566), BIELLA, GERARDO ROSARIO, Smith A., Reitano E, Gorba T, Ying Ql, Ying Qi-Long, Conti, L, Conti L, Sun Y, Sanzone, S, L. Conti, S. Sanzone, Toselli Mauro, Steven M Pollard (59560), Qi-Long Ying (59567), Q. L. Ying, Cattaneo Elena, Pollard, S M, Luciano Conti (59559), Y. R. Sun, Pollard Sm, Cattaneo E, Sun, Y R, Sveva Sanzone, Smith, A, Erika Reitano, Pollard Steven M, Yirui Sun, TOSELLI, MAURO GIUSEPPE, Thorsten Gorba, Ying, Q L, Yirui Sun (59565), Ying, QL, Conti Luciano, Gerardo Biella, Sun Yirui, Elena Cattaneo, E. Cattaneo, Mauro Toselli (59563), Austin Smith (59569), Qi-Long Ying, Biella Gerardo, Erika Reitano (59562), Pollard, SM, Cattaneo, E, Sanzone S, G. Biella, Gerardo Biella (59564), Gorba Thorsten, Gorba, T, A. Smith, Elena Cattaneo (59568), Sun, Y, S. M. Pollard, M. Toselli   +68 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

IRF2 is a master regulator of human keratinocyte stem cell fate

Nature Communications, 2019
Epidermal homeostasis requires long term stem cell function. Here, the authors apply transcriptional circuitry analysis based on integrated epigenomic profiling of primary human keratinocytes with high and low stem cell function to identify IRF2 as a ...
Nicolas Mercado, Gabi Schutzius, Christian Kolter, David Estoppey, Sebastian Bergling, Guglielmo Roma, Caroline Gubser Keller, Florian Nigsch, Adrian Salathe, Remi Terranova, John Reece-Hoyes, John Alford, Carsten Russ, Judith Knehr, Dominic Hoepfner, Alexandra Aebi, Heinz Ruffner, Tanner C. Beck, Sajjeev Jagannathan, Calla M. Olson, Hadley E. Sheppard, Selma Z. Elsarrag, Tewis Bouwmeester, Mathias Frederiksen, Felix Lohmann, Charles Y. Lin, Susan Kirkland   +26 more
doaj   +1 more source

25 Years of Epidermal Stem Cell Research [PDF]

, 2012
This is a chronicle of concepts in the field of epidermal stem cell biology and a historic look at their development over time. The past 25 years have seen the evolution of epidermal stem cell science, from first fundamental studies to a sophisticated ...
Ghadially, Ruby, Ruby Ghadially
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Epidermal stem cells: skin surveillance and clinical perspective

Journal of Translational Medicine
The skin epidermis is continually influenced by a myriad of internal and external elements. At its basal layer reside epidermal stem cells, which fuels epidermal renovation and hair regeneration with powerful self-renewal ability, as well as keeping ...
Xin Tang, Jiaqi Wang, Jiaoling Chen, Wanting Liu, Pei Qiao, Huiyi Quan, Zhiguo Li, Erle Dang, Gang Wang, Shuai Shao   +9 more
doaj   +1 more source

Two mechanisms regulate keratin K15 expression in keratinocytes:role of PKC/AP-1 and FOXM1 mediated signalling [PDF]

, 2012
Background: Keratin 15 (K15) is a type I keratin that is used as a marker of stem cells. Its expression is restricted to the basal layer of stratified epithelia, and the bulge in hair follicles.
Ahmad Waseem (155362), Amrita Bose, Ahmad Waseem, Leigh, IM, Waseem, Ahmad, Leigh, Irene M., Hutchison, Iain L., Iain L. Hutchison (155346), Hong Wan, Leigh Irene M., Hutchison, IL, Teh, MT, Iain L Hutchison, Muy-Teck Teh, Wan Hong, Teh, M-T, Wan, Hong, Bose, A, Irene M. Leigh (155355), Teh Muy-Teck, Muy-Teck Teh (155335), Amrita Bose (155329), Bose, Amrita, Wan, H, Waseem Ahmad, Irene M Leigh, Waseem, A, Hong Wan (149928), Hutchison Iain L., Teh, Muy-Teck, Bose Amrita   +30 more
core   +1 more source

Spatially Controlled Embedded Bioprinting of Prevascularized Spheroids‐Containing Biopatch Enables Functional Skin Regeneration

Advanced Healthcare Materials, EarlyView.
A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn, Gyu Tae Park, Dongjun Lee, Sik Yoon, Sae‐Ock Oh, Jae Ho Kim, Byoung Soo Kim   +6 more
wiley   +1 more source