Results 81 to 90 of about 5,980,424 (294)

The species specific effects of Mesenchymal stem cell conditioned medium on proliferating mouse and rat adult neural stem, progenitor cells [PDF]

, 2012
Adult stem cells reside in different tissues and organs of the adult organism. Among these cells are Mesenchymal stem cells (MSCs) and neural stem and progenitor cells (NSPCs).
Dechant, Franz - Xaver
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Differentiation of nonhuman primate pluripotent stem cells into functional keratinocytes

Stem Cell Research & Therapy, 2017
Background Epidermal grafting using cells derived from pluripotent stem cells will change the face of this side of regenerative cutaneous medicine.
Sophie Domingues, Yolande Masson, Aurore Marteyn, Jennifer Allouche, Anselme L. Perrier, Marc Peschanski, Cecile Martinat, Christine Baldeschi, Gilles Lemaître   +8 more
doaj   +1 more source

Chronic inflammation of middle ear cholesteatoma promotes its recurrence via a paracrine mechanism

Cell Communication and Signaling, 2021
Background Cholesteatoma disease is an expanding lesion in the middle ear. Hearing loss and facial paralysis alongside with other intracranial complications are found.
Matthias Schürmann, Felix Oppel, Senyao Shao, Verena Volland-Thurn, Christian Kaltschmidt, Barbara Kaltschmidt, Lars-Uwe Scholtz, Holger Sudhoff   +7 more
doaj   +1 more source

Identifiability and privacy in pluripotent stem cell research [PDF]

, 2014
Data sharing is an essential element of research; however, recent scientific and social developments have challenged conventional methods for protecting privacy.
Williams, C, Bredenoord, AL, Rooke, Heather, Isasi, R;Andrews, PW;Baltz, JM;Bredenoord, AL;Burton, P;Chiu, IM;Hull, SC;Jung, JW;Kurtz, A;Lomax, G;Ludwig, T;McDonald, M;Morris, C;Ng, HH;Rooke, H;Sharma, A;Stacey, GN;Williams, C;Zeng, F;Knoppers, BM, Baltz, Jay M, Sharma, A, Zeng, F, Ludwig, Tenneille, Kurtz, A, Morris, Clive, Ng, HH, Isasi, Rosario, McDonald, M, Kurtz, Andreas, Burton, P, Zeng, Fanyi, Chiu, Ing-Ming, Andrews, Peter W, Morris, C, Jung, J-W, Lomax, Geoffrey, Burton, Paul, Lomax, G, Sharma, Alka, Hull, SC, Chiu, I-M, Bredenoord, Annelien L, Andrews, PW, Stacey, GN, McDonald, Michael, Stacey, Glyn N, Jung, Ji-Won, Ludwig, T, Rooke, H, Knoppers, BM, Williams, Clare, Isasi, R, Baltz, JM, Baltz, Jay M., Andrews, Peter W., Ng, Huck Hui, Stacey, Glyn N., Bredenoord, Annelien L., Knoppers, Bartha Maria, Hull, Sara Chandros   +44 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation.

PLoS ONE, 2007
Activation of Myc induces epidermal stem cells to exit their niche and differentiate into sebocytes and interfollicular epidermis, a process that is associated with widespread changes in gene transcription. We have identified chromatin modifications that
Michaela Frye, Amanda G Fisher, Fiona M Watt   +2 more
doaj   +1 more source

Epidermal stem cells: Properties, markers, and location [PDF]

Proceedings of the National Academy of Sciences, 2000
Recent data indicate that stem cells exist in many tissues, including skeletal muscle, liver, and the central nervous system, some of them not known classically as having stem cells. The unexpected plasticity and the tremendous disease implications of these findings have created a lot of excitement (1, 2).
R M, Lavker, T T, Sun
openaire   +2 more sources

Human epidermal stem cell function is regulated by circadian oscillations

, 2013
SummaryHuman skin copes with harmful environmental factors that are circadian in nature, yet how circadian rhythms modulate the function of human epidermal stem cells is mostly unknown.
Serrano Pubull, Luis, 1982-, Solanas, Guiomar, Minkwitz, Susann, Lehner, Ben, 1978-, Janich, Peggy, 1981-, Luis, Nuno Miguel, 1982-, Toufighi, Kiana, 1980-, Aznar Benitah, Salvador, Solanas, G., Solanas G, Lehner, B., Toufighi K, Benitah SA, Serrano, L., Lehner B, Luis NM, Toufighi, K., Janich P, Janich, P., Benitah, S.A., Luis, N.M., Minkwitz S, Serrano L, Minkwitz, S.   +23 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source