Results 61 to 70 of about 5,980,424 (294)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Zinc flux in skin: Identity and function of metallothionein 1–positive cells in skin homeostasis
JID InnovationsZinc is essential for skin homeostasis, yet the identity and function of zinc-rich epidermal cells remain poorly defined. MT1 (metallothionein-1), a zinc-responsive protein, is commonly used as an intracellular zinc marker, but whether MT1+ cells ...
Sofia Brito +6 more
doaj +1 more source
New insights into inflammatory memory of epidermal stem cells
Frontiers in Immunology, 2023 Inflammatory memory, as one form of innate immune memory, has a wide range of manifestations, and its occurrence is related to cell epigenetic modification or metabolic transformation.
Dapeng Cheng +7 more
doaj +1 more source
Niche interactions in epidermal stem cells
World Journal of Stem Cells, 2015 Within the epidermis and dermis of the skin, cells secrete and are surrounded by the extracellular matrix (ECM), which provides structural and biochemical support. The ECM of the epidermis is the basement membrane, and collagen and other dermal components constitute the ECM of the dermis.
Hye-Ryung, Choi +3 more
openaire +2 more sources
Multi‐tasking epidermal stem cells: Beyond epidermal maintenance [PDF]
Development, Growth & Differentiation, 2018 Over the past decade, multiple stem cell compartments have been identified within the epidermis. These stem cell pools have different transcriptional properties, proliferative modes and anatomical locations, and they maintain distinct epidermal compartments.
Hironobu Fujiwara +2 more
openaire +2 more sources
Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]
, 2002 Pluripotent mouse embryonic stem (ES) cells can be expanded in large numbers in vitro owing to a process of symmetrical self-renewal. Self-renewal entails proliferation with a concomitant suppression of differentiation.
Burdon, Tom +4 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
مجله دانشگاه علوم پزشکی گرگان, 2012 Background and Objective: Epidermis is the outer layer of skin, regenerating continuously. Epidermal stem cells play important roles in tissue regeneration, scar regeneration and neoplasm formation.This study was displayed for the isolation and culture ...
Sheikhani N (BSc) +2 more
doaj
CosmeticsHuman skin homeostasis relies on the delicate equilibrium between epidermal stem cell renewal, dermoepidermal junction (DEJ) architecture, and environmental interactions.
Julien Chlasta +9 more
doaj +1 more source