Results 51 to 60 of about 5,980,424 (294)

Identification of a population of epidermal squamous cell carcinoma cells with enhanced potential for tumor formation. [PDF]

PLoS ONE, 2013
Epidermal squamous cell carcinoma is among the most common cancers in humans. These tumors are comprised of phenotypically diverse populations of cells that display varying potential for proliferation and differentiation. An important goal is identifying
Gautam Adhikary, Dan Grun, Candace Kerr, Sivaprakasam Balasubramanian, Ellen A Rorke, Mohan Vemuri, Shayne Boucher, Jackie R Bickenbach, Thomas Hornyak, Wen Xu, Matthew L Fisher, Richard L Eckert   +11 more
doaj   +1 more source

Stem Cell States, Fates, and the Rules of Attraction

, 2009
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different ...
Andrews, Peter W., Peterson, Carsten, Enver, Tariq, Pera, Martin, Peterson, Carsten,   +4 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The neural stem cell microenvironment [PDF]

, 2008
In mammals, neural stem cells appear early in development and remain active within the central nervous system for the whole life duration of the organism.
Kazanis, I., ffrench-Constant, C., Moss, L., Lathia, J.   +3 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Role of bulge epidermal stem cells and TSLP signaling in psoriasis

EMBO Molecular Medicine, 2019
Psoriasis is a common inflammatory skin disease involving a cross‐talk between epidermal and immune cells. The role of specific epidermal stem cell populations, including hair follicle stem cells (HF‐SCs) in psoriasis is not well defined.
Nuria Gago‐Lopez, Liliana F Mellor, Diego Megías, Guillermo Martín‐Serrano, Ander Izeta, Francisco Jimenez, Erwin F Wagner   +6 more
doaj   +1 more source

The Continuing Saga of Epidermal Stem Cells [PDF]

Journal of Investigative Dermatology, 2003
Ever sinceTill and McCulloch (1961) identified cells with the ability to recapitulate the hematopoietic tissue after radiation damage, isolating a pure population of stem cells from somatic tissues has been a primary goal. However, achieving success has been limited.
openaire   +2 more sources

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Stress vesicles link epidermal mechanotransduction to stem cell differentiation

Nature Communications
The skin exhibits extraordinary plasticity, enabling it to adapt to mechanical changes in the environment. While transient deformations are accommodated without lasting structural effects, sustained mechanical stress induces durable tissue changes.
Sixia Huang, Paola Kuri, Jonathan Zou, Adriana Blanco, Maxwell Marshall, Gabriella Rice, Stephen Prouty, Tzvete Dentchev, Miriam Doepner, Joel D. Boerckel, Brian C. Capell, Todd W. Ridky, Panteleimon Rompolas   +12 more
doaj   +1 more source