Results 41 to 50 of about 5,980,424 (294)

Regulation of Human Epidermal Stem Cell Proliferation and Senescence Requires Polycomb- Dependent and -Independent Functions of Cbx4

, 2011
SummaryHuman epidermal stem cells transit from a slow cycling to an actively proliferating state to contribute to homeostasis. Both stem cell states differ in their cell cycle profiles but must remain guarded from differentiation and senescence.
Guglielmo Roma, Michaela Frye, Stefania Mejetta, Elisabete Nascimento, Gloria Pascual, Peggy Janich, Luciano Di Croce, Nuno Miguel Luis, Bernd Kuebler, Salvador Aznar Benitah, Lluis Morey, Luca Cozutto, Cozutto, Luca, Nascimento, Elisabete, Mejetta, Stefania, Janich, Peggy, Roma, Guglielmo, Morey, Lluis, Luis, Nuno Miguel, Frye, Michaela, Kuebler, Bernd, Di Croce, Luciano, Pascual, Gloria, Benitah, Salvador Aznar   +23 more
core   +1 more source

Lack of correlation of stem cell markers in breast cancer stem cells [PDF]

, 2014
Background:Various markers are used to identify the unique sub-population of breast cancer cells with stem cell properties. Whether these markers are expressed in all breast cancers, identify the same population of cells, or equate to therapeutic ...
Y Liu, Appleyard, M. V., M V Appleyard, Liu, Y., P J Coates, Thompson, A. M., Boylan, M., Coates, P. J., Nenutil, R., M Boylan, A M Thompson, Murray, K., R Nenutil, K Murray   +13 more
core   +1 more source

Dielectrophoresis: A Review of Applications for Stem Cell Research [PDF]

, 2010
Dielectrophoresis can discriminate distinct cellular identities in heterogeneous populations, and monitor cell state changes associated with activation and clonal expansion, apoptosis, and necrosis, without the need for biochemical labels.
De Sousa, Paul, Ronald Pethig, Pells, Steve, Anoop Menachery, Menachery, Anoop, Paul De Sousa, Pethig, Ronald, Steve Pells   +7 more
core   +1 more source

Defining Epidermal Basal Cell States during Skin Homeostasis and Wound Healing Using Single-Cell Transcriptomics

Cell Reports, 2020
Summary: Our knowledge of transcriptional heterogeneities in epithelial stem and progenitor cell compartments is limited. Epidermal basal cells sustain cutaneous tissue maintenance and drive wound healing.
Daniel Haensel, Suoqin Jin, Peng Sun, Rachel Cinco, Morgan Dragan, Quy Nguyen, Zixuan Cang, Yanwen Gong, Remy Vu, Adam L. MacLean, Kai Kessenbrock, Enrico Gratton, Qing Nie, Xing Dai   +13 more
doaj   +1 more source

E-Cadherin regulates neural stem cell self-renewal

, 2009
E-Cadherin, a cell adhesion protein, has been shown to take part in the compartmentalization, proliferation, survival, and differentiation of cells.
DeVeale, B., Willaime-Morawek, S., van der Kooy, D., Balenci, L., Karpowicz, P., Inoue, T.   +5 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Dermal and epidermal cell functions in the growth and regeneration of hair follicles and other skin appendages [PDF]

, 1998
Epithelial-mesenchymal interactions are central to the development of skin and skin appendages in vertebrates. These interactions continue throughout adult life and underpin the cyclic growth and loss of hair in mammals. While the molecular basis of such
Gharzi, Ahmad
core  

Sensors of Succinate : Neural Stem Cell Grafts Fight Neuroinflammation

, 2018
In this issue of Cell Stem Cell, Peruzzotti-Jametti et al. (2018) demonstrate how neural stem cells, transplanted in a mouse model of multiple sclerosis, respond to extracellular succinate and modulate neuroinflammation by releasing anti-inflammatory ...
Olle Lindvall, Kokaia, Zaal, Zaal Kokaia, Lindvall, Olle, Kokaia, Zaal,, Lindvall, Olle,, Lund University.   +6 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Role of p63 in skin biology: its function in cell proliferation and differentiation [PDF]

, 2011
p63, a p53 family member, plays an essential role in epidermal development controlling several biological functions, some of which remain poorly understood.
Antonini, Dario
core   +1 more source