Results 31 to 40 of about 5,980,424 (294)
Heterogeneity and plasticity of epidermal stem cells [PDF]
Development, 2014 The epidermis is an integral part of our largest organ, the skin, and protects us against the hostile environment. It is a highly dynamic tissue that, during normal steady-state conditions, undergoes constant turnover. Multiple stem cell populations residing in autonomously maintained compartments facilitate this task.
Schepeler, Troels +2 more
openaire +3 more sources
Basal keratinocytes contribute to all strata of the adult zebrafish epidermis. [PDF]
PLoS ONE, 2014 The epidermis of terrestrial vertebrates is a stratified epithelium and forms an essential protective barrier. It is continually renewed, with dead corneocytes shed from the surface and replaced from a basal keratinocyte stem cell population.
Raymond T H Lee +2 more
doaj +1 more source
Epidermal stem cell dynamics [PDF]
Stem Cell Research & Therapy, 2011 Wong and Reiter have explored the possibility that hair follicle stem cells can give rise to basal cell carcinoma (BCC). They expressed in mice an inducible human BCC-derived oncogenic allele of Smoothened, SmoM2, under the control of either the cytokeratin 14 (K14) or cytokeratin 15 (K15) promoter.
openaire +2 more sources
Transcriptional profiling of ectoderm specification to keratinocyte fate in human embryonic stem cells. [PDF]
PLoS ONE, 2015 In recent years, several studies have shed light into the processes that regulate epidermal specification and homeostasis. We previously showed that a broad-spectrum γ-secretase inhibitor DAPT promoted early keratinocyte specification in human embryonic ...
Ana Mafalda Baptista Tadeu +6 more
doaj +1 more source
Origin and regenerative potential of vertebrate mechanoreceptor-associated stem cells [PDF]
, 2012 Widera D, Hauser S, Kaltschmidt C, Kaltschmidt B. Origin and regenerative potential of vertebrate mechanoreceptor-associated stem cells. Anatomy Research International.
Hauser, Stefan +4 more
core +1 more source
Studies on the behaviour of human pancreatic carcinoma cell lines, with particular reference to stem cells [PDF]
, 2010 PhDStem cell therapy represents a potential -cell replacement strategy in diabetes and a pancreatic cancer (PC) stem cell is an attractive therapeutic target in this dire disease. However, a normal stem cell remains unidentified and proposed malignant
Guppy, Naomi J
core +2 more sources
Nanotechnology Applied to Stem Cell-Substratum Interactions [PDF]
, 2008 The modulation of biological interaction with artificial surfaces is a vital aspect of biomaterials research. Perhaps the most challenging area is transplantation involving the introduction of stem cells into the body with their ability to ...
Aref, Amirreza
core +3 more sources
Frontiers in Cell and Developmental Biology, 2020 There are many studies devoted to the role of hair follicle stem cells in wound healing as well as in follicle self-restoration. At the same time, the influence of the inflammatory cells on the hair follicle cycling in both injured and intact skin is ...
Elena I. Morgun, Ekaterina A. Vorotelyak
doaj +1 more source
Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair. [PDF]
PLoS ONE, 2014 Cell fates are determined by specific transcriptional programs. Here we provide evidence that the transcriptional coactivator, Mediator 1 (Med1), is essential for the cell fate determination of ectodermal epithelia.
Keigo Yoshizaki +8 more
doaj +1 more source
Mechanisms regulating epidermal stem cells [PDF]
The EMBO Journal, 2012 The skin epidermis contains different appendages such as the hair follicle and the sebaceous glands. Recent studies demonstrated that several types of stem cells (SCs) exist in different niches within the epidermis and maintain discrete epidermal compartments, but the exact contribution of each SC populations under physiological conditions is still ...
Beck, Benjamin, Blanpain, Cédric
openaire +3 more sources