Results 21 to 30 of about 576 (142)

An 81-Year-Old Woman with Recalcitrant Blisters

Dermatopathology, 2018
Epidermolysis bullosa acquisita (EBA) is a rare mucocutaneous blistering disorder with typical onset in adulthood. Diagnosis and management can be difficult owing to the variability in presentation and clinical manifestation.
Daniel C. Butler
doaj   +1 more source

Involvement of palms and soles in patients with autoimmune bullous diseases: a comparative analysis of a diagnostically relevant localization

Frontiers in Immunology, 2023
IntroductionThe involvement of palms and soles is variable among disease entities belonging to autoimmune bullous diseases (AIBD). We present our own clinical-laboratory experience concerning presentations of skin lesions on palms and soles in the ...
Magdalena Jałowska, Maciej Spałek, Monika Bowszyc-Dmochowska, Justyna Gornowicz- Porowska, Marian Dmochowski   +4 more
doaj   +1 more source

Pathological Relevance of Anti-Hsp70 IgG Autoantibodies in Epidermolysis Bullosa Acquisita

Frontiers in Immunology, 2022
Stress-induced heat shock protein 70 (Hsp70) is a key intra- and extracellular molecular chaperone implicated in autoimmune processes. Highly immunogenic extracellular Hsp70 can activate innate and acquired (adaptive) immune responses driving the ...
Stefan Tukaj, Jagoda Mantej, Krzysztof Sitko, Detlef Zillikens, Ralf J. Ludwig, Katja Bieber, Michael Kasperkiewicz   +6 more
doaj   +1 more source

Epidermolysis Bullosa Acquisita Occuring In A Patient With Systemic Lupus Erythematosus

Saintika Medika, 2019
Epidermolysis Bullosa Acquisita (EBA) is a rare, chronic autoimmune subepidermal bullous disease and has been noted to be associated with systemic lupus erythematosus (SLE). The incidence of EBA and SLE in one patient within the period of 1980-1990 found
Lita setyowatie, Yustian Devika Rahmawati, Arif Widiatmoko, Diah Prabawati Retnani   +3 more
doaj   +1 more source

Epidermolysis Bullosa (EB) Acquisita in an Adult Patient with Previously Unrecognized Mild Dystrophic EB and Biallelic COL7A1 Mutations

Acta Dermato-Venereologica, 2018
Circulating anti-type VII collagen autoantibodies are frequently detected in patients with recessive dystrophic epidermolysis bullosa (RDEB). However, evidence supporting their pathogenic role in inducing epidermolysis bullosa acquisita (EBA) has been ...
Liliana Guerra, Angelo Giuseppe Condorelli, Paola Fortugno, Valentina Calabresi, Cristina Pedicelli, Giovanni Di Zenzo, Daniele Castiglia   +6 more
doaj   +1 more source

A Missense Variant Affecting the N-Terminal Domain of the Laminin-332 β3 Chain Results in a Distinct Form of Junctional Epidermolysis Bullosa With Altered Granulation Tissue Response and No New Blistering: A Second Family Report. [PDF]

Pediatr Dermatol
ABSTRACT Junctional epidermolysis bullosa (JEB) is a rare genodermatosis characterized by fragility of the skin and mucous membranes due to alterations in the dermal epidermal junction. This condition manifests as mechanically induced bullous lesions that heal with hypertrophic granulation tissue and/or atrophic scars.
Goldoni M, Torres B, Pettinato M, Gennaro A, Biagini T, Condorelli AG, Monetta R, Mazza T, Bernardini L, Mattina T.   +9 more
europepmc   +2 more sources

Childhood epidermolysis bullosa acquisita: Confirmation of diagnosis by skin deficient in Type VII Collagen, enzyme-linked immunosorbent assay, and immunoblotting

Indian Journal of Dermatology, 2016
Epidermolysis bullosa acquisita (EBA) is an acquired subepidermal bullous disorder characterized by autoantibodies against Type VII collagen. It usually affects adults; childhood EBA is rare. We describe a 10-year-old girl presenting with recurrent tense
Nupur Goyal, Raghavendra Rao, C Balachandran, Sathish Pai, Balbir S Bhogal, Enno Schmidt, Detlef Zillikens   +6 more
doaj   +1 more source

Risk factors and sequelae of epidermolysis bullosa acquisita: A propensity-matched global study in 1,344 patients

Frontiers in Immunology, 2023
Identification of risk factors and sequelae of any given disease is of key importance. For common diseases, primary prevention and disease management are based on this knowledge.
Khalaf Kridin, Khalaf Kridin, Khalaf Kridin, Artem Vorobyev, Cristian Papara, David A. De Luca, Katja Bieber, Ralf J. Ludwig, Ralf J. Ludwig   +8 more
doaj   +1 more source

Cutaneous kinase activity correlates with treatment outcomes following PI3K delta inhibition in mice with experimental pemphigoid diseases

Frontiers in Immunology, 2022
Chronic blistering at the skin and/or mucous membranes, accompanied by a varying degree of inflammation, is the clinical hallmark of pemphigoid diseases that impose a major medical burden.
Saeedeh Ghorbanalipoor, Shirin Emtenani, Melissa Parker, Mayumi Kamaguchi, Colin Osterloh, Manuela Pigors, Natalie Gross, Stanislav Khil’chenko, Anika Kasprick, Sabrina Patzelt, Diana Wortmann, Ibrahim O. Ibrahim, Kentaro Izumi, Stephanie Goletz, Katharina Boch, Kathrin Kalies, Katja Bieber, Paul Smith, Enno Schmidt, Ralf J. Ludwig   +19 more
doaj   +1 more source

Epidermolysis bullosa acquisita: current diagnosis and therapy

Dermatology Reports, 2011
Epidermolysis bullosa acquisita (EBA) is an acquired, autoimmune subepidermal blistering disease with an approximate prevalence of 0,2/million people. The hallmark of EBA is the presence of autoantibodies (mainly IgG class) to anchoring fibril collagen ...
Christine R. Mehren, Robert Gniadecki
doaj   +1 more source