Results 41 to 50 of about 22,551 (179)

Epidermolysis bullosa acquisita

, 2013
Epidermolysis bullosa acquisita (EBA) is a chronic autoimmune subepidermal bullous disease with clinical features similar to the genetic form of dystrophic epidermolysis bullosa.
김수찬, 김종훈
core   +1 more source

Therapeutic effects of Fc gamma RIV inhibition are mediated by selectively blocking immune complex-induced neutrophil activation in epidermolysis bullosa acquisita

Frontiers in Immunology, 2022
Epidermolysis bullosa acquisita (EBA) is a subepidermal autoimmune bullous disease caused by autoantibodies targeting type VII collagen (COL7). It is characterized by inflammation and subepidermal blistering mainly through immune complex (IC)-mediated ...
Swantje C. Haeger, Khalaf Kridin, Khalaf Kridin, Mario Pieper, Laura Griewahn, Falk Nimmerjahn, Detlef Zillikens, Detlef Zillikens, Peter König, Ralf J. Ludwig, Ralf J. Ludwig, Jennifer E. Hundt   +11 more
doaj   +1 more source

Expression of the α6β4 Integrin in Lesional Skin Differentiates Bullous Pemphigoid (BP) from Epidermolysis Bullosa Acquisita (EBA)

Journal of Investigative Dermatology, 1992
The integrin alpha 6 beta 4 complex is a protein of the membrane of basal keratinocytes, localized at the surface of cells in contact with the basement membrane zone in normal skin. The expression of alpha 6 beta 4 was investigated in several autoimmune blistering skin diseases including bullous pemphigoid (BP), epidermolysis bullosa acquisita (EBA ...
H. Michalaki, M. J. Staquet, A. Cerri, E. Berti, P. Roche, P. Machado, J. F. Nicolas   +6 more
openaire   +3 more sources

The G Protein-Coupled Receptor (GPR) 15 Counteracts Antibody-Mediated Skin Inflammation

Frontiers in Immunology, 2020
The G protein-coupled receptor 15 (GPR15) has recently been highlighted as an important regulator of T cell trafficking into the gut under physiological and pathophysiological conditions.
Lina Jegodzinski, Tanya Sezin, Karin Loser, Sadegh Mousavi, Detlef Zillikens, Detlef Zillikens, Christian D. Sadik, Christian D. Sadik   +7 more
doaj   +1 more source

A Missense Variant Affecting the N-Terminal Domain of the Laminin-332 β3 Chain Results in a Distinct Form of Junctional Epidermolysis Bullosa With Altered Granulation Tissue Response and No New Blistering: A Second Family Report. [PDF]

Pediatr Dermatol
ABSTRACT Junctional epidermolysis bullosa (JEB) is a rare genodermatosis characterized by fragility of the skin and mucous membranes due to alterations in the dermal epidermal junction. This condition manifests as mechanically induced bullous lesions that heal with hypertrophic granulation tissue and/or atrophic scars.
Goldoni M, Torres B, Pettinato M, Gennaro A, Biagini T, Condorelli AG, Monetta R, Mazza T, Bernardini L, Mattina T.   +9 more
europepmc   +2 more sources

Bruton tyrosine kinase (Btk) in neutrophils is indispensable for initiating and maintaining skin inflammation in a model of pemphigoid diseases

British Journal of Pharmacology, Volume 183, Issue 10, Page 2446-2463, May 2026.
Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich, Paul Schilf, Sripriya Murthy, Sina Gonther, Mareike Neumann, Christoph M. Hammers, Jasper N. Pruessmann, Christian D. Sadik   +7 more
wiley   +1 more source

A review of scoring instruments for the assessment of disease severity in epidermolysis bullosa acquisita

Dermatologica Sinica
Epidermolysis bullosa acquisita (EBA) is a rare, chronic autoimmune blistering disease (AIBD) characterized by mucocutaneous blistering. Typically acquired in adulthood, EBA manifests in a diverse array of clinical variants and significantly impacts ...
Aalia Syed, Sera Sarsam, Brice Serquina, Dédée F. Murrell   +3 more
doaj   +1 more source

Epidermolysis bullosa acquisita associated with vitiligo, Graves' disease and nephrotic syndrome

, 2004
Epidermolysis bullosa acquisita. is a rare autoimmune disease which may be associated with various autoimmune diseases. Presented is an unusual case of a patient with vitiligo, Graves' disease, nephrotic syndrome and epidermolysis bullosa acquisita ...
ERGUN, SAFİYE ATLAS TÜLİN
core   +1 more source

Molecular cloning and characterization of a cDNA encoding canine type VII collagen non-collagenous (NC1) domain, the target antigen of autoimmune disease epidermolysis bullosa acquisita (EBA)

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1998
Type VII collagen, the major component of anchoring fibrils, serves as tight adhesion of skin basement membrane zone (BMZ) through its amino-terminal non-collagenous (NC1) domain. The NC1 domain is targeted by autoantibodies of an acquired blistering skin disease termed epidermolysis bullosa acquisita (EBA) naturally occurring in humans and dogs.
Xu, Luting, Chen, Mei, Peng, Jun, O’Toole, Edel A., Woodley, David T., Chan, Lawrence S.   +5 more
openaire   +2 more sources

Epidermolysis Bullosa Acquisita Responsive to Dapsone Therapy

, 2001
Background: Epidermolysis bullosa acquisita (EBA) is a chronic subepidermal blistering disease that is frequently resistant to therapy. Objective: A 58-year-old man who had a one-year history of a bullous eruption involving the hands, forearms, trunk ...
Jeffrey P. Callen, Amy P. Hughes
core   +1 more source