Results 41 to 50 of about 576 (142)

Bruton tyrosine kinase (Btk) in neutrophils is indispensable for initiating and maintaining skin inflammation in a model of pemphigoid diseases

British Journal of Pharmacology, Volume 183, Issue 10, Page 2446-2463, May 2026.
Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich, Paul Schilf, Sripriya Murthy, Sina Gonther, Mareike Neumann, Christoph M. Hammers, Jasper N. Pruessmann, Christian D. Sadik   +7 more
wiley   +1 more source

A review of scoring instruments for the assessment of disease severity in epidermolysis bullosa acquisita

Dermatologica Sinica
Epidermolysis bullosa acquisita (EBA) is a rare, chronic autoimmune blistering disease (AIBD) characterized by mucocutaneous blistering. Typically acquired in adulthood, EBA manifests in a diverse array of clinical variants and significantly impacts ...
Aalia Syed, Sera Sarsam, Brice Serquina, Dédée F. Murrell   +3 more
doaj   +1 more source

Epidermolysis Bullosa Acquisita: The 2019 Update

Frontiers in Medicine, 2019
Epidermolysis bullosa acquisita (EBA) is an orphan autoimmune disease. Patients with EBA suffer from chronic inflammation as well as blistering and scarring of the skin and mucous membranes.
Hiroshi Koga, Catherine Prost-Squarcioni, Hiroaki Iwata, Marcel F. Jonkman, Ralf J. Ludwig, Katja Bieber   +5 more
doaj   +1 more source

Whole-Genome Expression Profiling in Skin Reveals SYK As a Key Regulator of Inflammation in Experimental Epidermolysis Bullosa Acquisita

Frontiers in Immunology, 2018
Because of the morbidity and limited therapeutic options of autoimmune diseases, there is a high, and thus far, unmet medical need for development of novel treatments.
Unni K. Samavedam, Nina Mitschker, Anika Kasprick, Katja Bieber, Enno Schmidt, Enno Schmidt, Tamás Laskay, Andreas Recke, Andreas Recke, S. Goletz, Gestur Vidarsson, Franziska S. Schulze, Mikko Armbrust, Katharina Schulze Dieckhoff, Hendri H. Pas, Marcel F. Jonkman, Kathrin Kalies, Detlef Zillikens, Detlef Zillikens, Yask Gupta, Saleh M. Ibrahim, Ralf J. Ludwig, Ralf J. Ludwig   +22 more
doaj   +1 more source

Spontaneous autoimmune subepidermal blistering diseases in animals: a comprehensive review

BMC Veterinary Research, 2023
Autoimmune subepidermal blistering diseases (AISBDs) are rare skin disorders of animals that were first identified in dogs but several AISBDs are now recognised in other companion animal species.
Petra Bizikova, Thierry Olivry, Keith Linder, Jan Rybnicek   +3 more
doaj   +1 more source

The complement receptor C5aR2 regulates neutrophil activation and function contributing to neutrophil-driven epidermolysis bullosa acquisita

Frontiers in Immunology, 2023
IntroductionThe function of the second receptor for the complement cleavage product C5a, C5aR2, is poorly understood and often neglected in the immunological context.
Daniel L. Seiler, Katja H. Kähler, Marie Kleingarn, Christian D. Sadik, Christian D. Sadik, Katja Bieber, Katja Bieber, Katja Bieber, Jörg Köhl, Jörg Köhl, Ralf J. Ludwig, Ralf J. Ludwig, Ralf J. Ludwig, Christian M. Karsten   +13 more
doaj   +1 more source

Pyoderma Gangrenosum as the First Manifestation of Inflammatory Bowel Disease: A Case Report

Case Reports in Gastrointestinal Medicine, Volume 2026, Issue 1, 2026.
Approximately 50% of patients with inflammatory bowel disease (IBD) exhibit extraintestinal manifestations, among which skin and mucosal lesions are common. However, pyoderma gangrenosum occurs in only 1%‐2% of IBD patients. We report the case of a 23‐year‐old male patient who was admitted to the hospital with pyoderma gangrenosum that was unresponsive
Nam Hoai Nguyen, Tan Thi Tran, Trang Thu Khuc, Yen Thi Lo, Ha Thi-Ngoc Doan, Hieu Van Nguyen, Long Cong Nguyen, Marcel Cc Machado   +7 more
wiley   +1 more source

ROS‐Scavenging Multifunctional Microneedle Patch Facilitating Wound Healing

Advanced Healthcare Materials, Volume 14, Issue 31, December 8, 2025.
A reactive oxygen species (ROS) scavenging and immunomodulatory microneedle patch based on hyaluronic acid methacrylate (HaMA) and Flightless I (Flii)‐siRNA‐laden arginine functionalized poly (β‐amino ester)/alginate particles is developed for chronic wound healing applications.
Mahshid Kharaziha, Sahar Salehi, Mahshid Shokri, Seyed Mohsen Ahmadi Tafti, Thomas Scheibel   +4 more
wiley   +1 more source

Reduced Skin Blistering in Experimental Epidermolysis Bullosa Acquisita After Anti-TNF Treatment

Molecular Medicine, 2016
Epidermolysis bullosa acquisita (EBA) is a difficult-to-treat subepidermal autoimmune blistering skin disease (AIBD) with circulating and tissue-bound anti-type VII collagen antibodies.
Misa Hirose, Anika Kasprick, Foteini Beltsiou, Katharina Schulze Dieckhoff, Franziska Sophie Schulze, Unni K J S R L Samavedam, Jennifer E Hundt, Hendri H Pas, Marcel F Jonkman, Enno Schmidt, Kathrin Kalies, Detlef Zillikens, Ralf J Ludwig, Katja Bieber   +13 more
doaj   +1 more source

Clinical and immunopathological spectrum of immunoglobulin M pemphigoid: a multicenter case series

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 12, Page 1555-1564, December 2025.
Summary Background and Objectives Pemphigoid diseases are primarily mediated by IgG or IgA autoantibodies against the cutaneous basement membrane zone (BMZ). Although recent observations suggest the existence of exclusively IgM‐mediated pemphigoid disease, a larger study is lacking.
Kaan Yilmaz, Stephanie Goletz, Christoph M. Hammers, Katharina Boch, Claudia Zeidler, Henning Wiegmann, Estelle Bergmann, Tina Rastegar Lari, Onur Dikmen, Nina Häring, Robert Strohal, Andreas Kleinheinz, Eva N. Hadaschik, Nina van Beek, Sonja Ständer, Enno Schmidt   +15 more
wiley   +1 more source