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Evolving Lessons on Metazoan Primordial Germ Cells in Diversity and Development. [PDF]
ABSTRACT Germ cells are pivotal for the continuation of biological species. The metazoan germline develops from primordial germ cells (PGCs) that undergo multiple rounds of mitotic divisions. The PGCs are specified by either maternal inheritance of asymmetrically polarized cytoplasmic mRNAs/proteins (found in roundworms, flies, fishes, frogs, and fowl)
Bhattacharya I+5 more
europepmc +2 more sources
Epigenetic regulation in lung cancer
Role of epigenetics in lung cancer. Epigenetics is considered the main cause of lung cancer. Epigenetics is categorized into three phenomena: histone modification, DNA methylation, and noncoding RNAs. One of the main approaches to controlling lung cancer is early diagnosis.
Shahin Ramazi+3 more
wiley +1 more source
Our study in Tenebrio molitor employed behavioral and proteomic analyses to establish a correlation between female mate choice and molecular changes in the female brain. We found that females preferred mating with more attractive males, who in turn had a greater likelihood of successfully mating and producing more larvae with attractive males than with
Miguel Hernández‐Villanueva+3 more
wiley +1 more source
Abstract Introduction Guided by Erikson's theory of psychosocial development, the present study investigated whether themes of trust, identity, intimacy, and generativity are represented in older adults' most important autobiographical memories. Furthermore, we tested whether these themes are associated with certain life periods and whether having ...
Lisa Nusser, Daniel Zimprich, Tabea Wolf
wiley +1 more source
In vitro culture of reptile PGCS to preserve endangered species
Abstract Primordial germ cells (PGCs), are the source of gametes in vertebrates. There are similarities in the development of PGCs of reptiles with avian and mammalian species PGCs development. PGCs culture has been performed for avian and mammalian species but there is no report for reptilian PGCs culture. In vitro culture of PGCs is needed to produce
Afsaneh Golkar‐Narenji+5 more
wiley +1 more source
Re‐recognition of innate immune memory as an integrated multidimensional concept
Abstract In the past decade, the concept of immunological memory, which has long been considered a phenomenon observed in the adaptive immunity of vertebrates, has been extended to the innate immune system of various organisms. This de novo immunological memory is mainly called “innate immune memory”, “immune priming”, or “trained immunity” and has ...
Chang Tang+2 more
wiley +1 more source
Once More unto the Breach: Kant and Race
Abstract The last thirty years has seen an explosion of literature on Kant and race. Once overlooked essays and notes in which Kant expresses contempt for nonwhite people and support for slavery have been brought to light, and many scholars have wrestled with the question of how a philosopher who stressed the equal dignity of all human beings could ...
Samuel Fleischacker
wiley +1 more source
Current status of genome‐wide epigenetic profiling of mammalian preimplantation embryos
Abstract Background Genome‐wide information on epigenetic modifications in mammalian preimplantation embryos was an unexplored sanctuary of valuable research insights protected by the difficulty of its analysis. However, that is no longer the case, and many epigenome maps are now available for sightseeing there.
Shuntaro Ikeda
wiley +1 more source
Gut bacterial profiles in Parkinson's disease: A systematic review
The role of gut bacteria in association with Parkinson's disease (PD) may involve the alterations of bacteria with the capacity to produce short‐chain fatty acids (SCFAs) and an increase in putative pathobionts, which may work together to potentially impair the intestinal barrier and/or blood–brain barrier integrity, stimulating systemic and neural ...
Zhe Li+17 more
wiley +1 more source
Epigenetic alterations—The silent indicator for early aging and age‐associated health‐risks
An epigenetic alteration like DNA methylation, Histone modification, or miRNA production can potentially influence an individual's genetic expression without changing their sequence. The change in epigenome‐induced genetic alteration can cause early aging and age‐related health risk.
Poulami Dhar+2 more
wiley +1 more source