Results 91 to 100 of about 365,239 (262)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. [PDF]

, 2016
High hyperdiploidy (HD), the most common cytogenetic subtype of B-cell acute lymphoblastic leukemia (B-ALL), is largely curable but significant treatment-related morbidity warrants investigating the biology and identifying novel drug targets.
de Smith, Adam J, Endicott, Alyson A, Francis, Stephen S, Hansen, Helen M, Metayer, Catherine, Ojha, Juhi, Sanders, Erica, Smirnov, Ivan, Termuhlen, Amanda M, Walsh, Kyle M, Wiemels, Joseph L   +10 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Age reprogramming and epigenetic rejuvenation

Epigenetics & Chromatin, 2018
Age reprogramming represents a novel method for generating patient-specific tissues for transplantation. It bypasses the de-differentiation/redifferentiation cycle that is characteristic of the induced pluripotent stem (iPS) and nuclear transfer ...
Prim B. Singh, Andrew G. Newman
doaj   +1 more source

DNA methylation and socioeconomic status in a Mexican-American birth cohort. [PDF]

, 2018
Background: Maternal social environmental stressors during pregnancy are associated with adverse birth and child developmental outcomes, and epigenetics has been proposed as a possible mechanism for such relationships.
Coker, Eric, Eskenazi, Brenda, Gunier, Robert, HOLLAND, Nina, Huen, Karen   +4 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Examining epigenetic aging in the post-mortem brain in attention deficit hyperactivity disorder

Frontiers in Genetics
Mathematical algorithms known as “epigenetic clocks” use methylation values at a set of CpG sites to estimate the biological age of an individual in a tissue-specific manner. These clocks have demonstrated both acceleration and delays in epigenetic aging
Gauri G. Shastri, Gauri G. Shastri, Gustavo Sudre, Kwangmi Ahn, Benjamin Jung, Bhaskar Kolachana, Pavan K. Auluck, Laura Elnitski, Philip Shaw, Philip Shaw   +9 more
doaj   +1 more source

A general mathematical framework for understanding the behavior of heterogeneous stem cell regeneration

, 2019
Stem cell heterogeneity is essential for the homeostasis in tissue development. This paper established a general formulation for understanding the dynamics of stem cell regeneration with cell heterogeneity and random transitions of epigenetic states. The
Lei, Jinzhi
core   +1 more source

Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort [PDF]

, 2013
Data from epidemiological and animal model studies suggest that nutrition during pregnancy may affect the health status of subsequent generations. These transgenerational effects are now being explained by disruptions at the level of the epigenetic ...
A Kerjean, A Murrell, A Soubry, AD Stein, Adelheid Soubry, Amy Murtha, AP Feinberg, Autumn Bernal, BE Levin, BR Carone, BT Heijmans, C Gemma, C Gicquel, C Hoyo, C Hoyo, Cathrine Hoyo, CC Boissonnas, DC Dolinoy, DC Dolinoy, DJ Barker, Frances Wang, G Kaati, GA Dunn, GP Ravelli, H Boerschmann, H Cui, H Cui, H Cui, J Baker, J Frystyk, JA McKay, Joanne Kurtzberg, Joellen M Schildkraut, JS Dyer, KJ Stothard, LM McCowan, M Braunschweig, M Cruz-Correa, M Ollikainen, ME Pembrey, ME Pembrey, MJ Steenman, MJ Sullivan, Q Wu, R Barres, R Figueroa-Colon, R Loomba, RA Waterland, RA Waterland, RA Waterland, Randy L Jirtle, RC Painter, RC Painter, RL Jirtle, RP Steegers-Theunissen, S Honda, S Katari, S Pathak, SA Tanumihardjo, SD McDonald, SF Ng, SK Murphy, SK Murphy, SK Murphy, SS Du Plessis, Susan K Murphy, W Chao, Z Huang, Zhiqing Huang   +68 more
core   +3 more sources