Results 111 to 120 of about 5,479,707 (298)
Quantitative investigations of FXN transcription and epigenetic modifications, including histone acetylation and methylation, in FRDA human and mouse tissues [PDF]
, 2009 This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel University.Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder characterized by progressive gait and, limb ataxia, cardiomayopathy ...
Trabzuni, Daniah M
core +3 more sources
BiomedicinesIntroduction: Cardiovascular diseases stand as the leading global cause of mortality. Major modifiable risk factors encompass overweight/obese conditions, high blood pressure, elevated LDL cholesterol, diabetes, smoking, secondhand smoke exposure ...
Davide Marinello +7 more
doaj +1 more source
Mechanisms underlying epigenetic gene silencing in maize [PDF]
Higher organisms can regulate gene expression through changes in epigenetic marks present on the genome. However, how this regulation takes place in organisms with highly repetitive/complex genomes is not well understood.
Schafer, David Gerald
core
Epigenetic signatures, age acceleration, and injury risk in elite female and male soccer players
Physical activity has been extensively associated with epigenetic modifications. However, the potential contribution of DNA methylation patterns to sports injury susceptibility remains largely unexplored, particularly among high-performance athletes ...
Rodas, Gil +19 more
core +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Age & Opportunity annual report 2011
, 2012 Strategic report for Age & Oppertunity ...
Age & Opportunity
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BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
Investigation of hallmark epigenetic changes in a cancer stem cell model [PDF]
, 2010 Epigenetic control of gene expression is vital for normal development and differentiation of cells, and is also important in the development of disease.
Wild, L.
core
Associations between epigenetic age and brain age in young people [PDF]
Recent research suggests biological age, based on epigenetic or neuroimaging measures, may predict health traits in adulthood more accurately than chronological age. However, it is unclear if these findings apply earlier in life. We aimed to characterise
Baltramonaityte, Vilte +6 more
core +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source