Results 101 to 110 of about 5,571,062 (272)

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Epigenetic aging acceleration among World Trade Center-exposed community members

Scientific Reports
Aging is a complex biological process, and some individuals are aging faster or slower than expected. This phenomenon of aging acceleration occurs when biological age exceeds chronological age and can be assessed by epigenetic clock estimation.
Stephanie Tuminello, Yibeltal Arega Ashebir, Chanel Schroff, Sitharam Ramaswami, Nedim Durmus, Yu Chen, Matija Snuderl, Yongzhao Shao, Joan Reibman, Alan A. Arslan   +9 more
doaj   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Microglial Replacement Reverses Age-Associated Epigenetic Modifications Despite Accelerating Epigenetic Age

aging and disease
Microglial replacement is emerging as a promising concept for treating age-related disorders, but effects on epigenetic age remain unclear. Here, we examined DNA methylation dynamics in microglia from young and old mice and evaluated how ischemic stroke and microglial depletion/repopulation (D/R) influence their epigenetic landscape.
Maria, Arbaizar-Rovirosa, Raúl F, Pérez, Alfonso, Peñarroya, Mattia, Gallizioli, Mario F, Fraga, Anna M, Planas   +5 more
openaire   +2 more sources

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Epigenetic age acceleration is associated with blood lipid levels in a multi-ancestry sample of older U.S. adults

BMC Medical Genomics
Background Dyslipidemia, which is characterized by an unfavorable lipid profile, is a key risk factor for cardiovascular disease (CVD). Understanding the relationships between epigenetic aging and lipid levels may help guide early prevention and ...
Lisha Lin, Jenna Kiryakos, Farah Ammous, Scott M. Ratliff, Erin B. Ware, Jessica D. Faul, Sharon L.R. Kardia, Wei Zhao, Kira S. Birditt, Jennifer A. Smith   +9 more
doaj   +1 more source

Assessing the association of epigenetic age acceleration with osteoarthritis in the Multicenter Osteoarthritis Study (MOST). [PDF]

PURPOSE: Advancing age is one of the strongest risk factors for osteoarthritis (OA). DNA methylation-based measures of epigenetic age acceleration may provide insights into mechanisms underlying OA.
Felson, David, Haugen, Ida, Torner, James, Yau, Michelle, Okoro, Paul, Nevitt, Michael, Lewis, Cora, Lynch, John   +7 more
core   +1 more source

Epigenetic age acceleration of CD4+ T lymphocytes and monocytes in uninfected, AHI pre-ART, and AHI post-ART participants.

, 2021
a. Bar graph showing mean +SEM epigenetic age acceleration calculated by DNAmAge-Biological Age (Years) in CD4+ T cells (white bar) and monocytes (solid bar) at pre-ART and post-ART timepoints for AHI participants. b.
Andrew C. Belden (10296401), Michael J. Corley (7447133), Nisakorn Ratnaratorn (11273550), Victor Valcour (22964), Merlin Robb (373375), Robert Paul (22962), Sandhya Vasan (102251), Eugene Kroon (673318), Nitiya Chomchey (327683), Carlo Sacdalan (11273544), Lishomwa C. Ndhlovu (7122293), Kyu S. Cho (11273553), Alina PS Pang (11273547), Denise Hsu (11273556), Donn Colby (447929), Serena Spudich (202054)   +15 more
core   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

Heavy metals, epigenetic aging, and mortality: A cohort study

Ecotoxicology and Environmental Safety
Background: Aging is a multifaceted biological process modulated by interplay of genetic determinants and environmental influences. However, the role of epigenetic aging in the association between environmental exposures and mortality risk in human ...
Hua Wang, Yunyun Liu, Shuxiang Yan, Chenbei Li, Jinxin Tang, Hongkun Hu, Mingyang Wu, Chao Tu   +7 more
doaj   +1 more source