Results 81 to 90 of about 24,360 (295)

Association of Epigenetic Age and Outcome in Critically Ill Patients

Critical Care Explorations
OBJECTIVES:. DNA methylation can be used to determine an individual’s biological age, as opposed to chronological age, an indicator of underlying health status.
Archana Sharma-Oates, PhD, Jack Sullivan, PhD, Daniel Pestana, MSc, Claudia C. dos Santos, MD, Alexandra Binnie, MD, Janet M. Lord, PhD   +5 more
doaj   +1 more source

Accelerated Epigenetic Ageing in Major Depressive Disorder [PDF]

, 2017
AbstractBackgroundMajor depressive disorder (MDD) is a severe, heritable psychiatric disorder associated with shortened lifespan and comorbidities of advancing age. It is unknown however whether MDD is associated with accelerated biological ageing relative to chronological age.
Whalley, Heather C, Gibson, Jude, Marioni, Riccardo, Walker, Rosie M, Clarke, Toni-Kim, Howard, David M, Adams, Mark J, Hall, Lynsey, Morris, Stewart, Deary, Ian J, Porteous, David, Evans, Kathryn L, McIntosh, Andrew M   +12 more
openaire   +1 more source

Alcohol consumption and epigenetic age acceleration across human adulthood

Aging, 2023
The alcohol-associated biological aging remains to be studied across adulthood. We conducted linear regression analyses to investigate the associations between alcohol consumption and two DNA methylation-based biological age acceleration metrics in 3823 Framingham Heart Study participants (24-92 years and 53.8% women) adjusting for covariates.
Wang, Mengyao, Li, Yi, Lai, Meng, Nannini, Drew R., Hou, Lifang, Joehanes, Roby, Huan, Tianxiao, Levy, Daniel, Ma, Jiantao, Liu, Chunyu   +9 more
openaire   +2 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Epigenetic age acceleration, neonatal morbidities, and neurobehavioral profiles in infants born very preterm

Epigenetics, 2023
Epigenetic age acceleration is a risk factor for chronic diseases of ageing and may reflect aspects of biological ageing. However, few studies have examined epigenetic ageing during the early neonatal period in preterm infants, who are at heightened risk
Uriel Paniagua, Barry M. Lester, Carmen J. Marsit, Marie Camerota, Brian S. Carter, Jennifer F. Check, Jennifer Helderman, Julie A. Hofheimer, Elisabeth C. McGowan, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Sheri A. DellaGrotta, Lynne M. Dansereau, T. Michael O’Shea, Todd M. Everson   +15 more
doaj   +1 more source

Correlation of an epigenetic mitotic clock with cancer risk. [PDF]

, 2016
BACKGROUND: Variation in cancer risk among somatic tissues has been attributed to variations in the underlying rate of stem cell division. For a given tissue type, variable cancer risk between individuals is thought to be influenced by extrinsic factors ...
Beck, Stephan, Kuh, Diana, Leslie, R David, Paul, Dirk S, Rakyan, Vardhman K, Teschendorff, Andrew E, Widschwendter, Martin, Wong, Andrew, Yang, Zhen, Zheng, Shijie C   +9 more
core   +3 more sources

Epigenetic Age Acceleration Assessed with Human White-Matter Images [PDF]

The Journal of Neuroscience, 2017
The accurate estimation of age using methylation data has proved a useful and heritable biomarker, with acceleration in epigenetic age predicting a number of age-related phenotypes. Measures of white matter integrity in the brain are also heritable and highly sensitive to both normal and pathological aging processes across adulthood.
Karen Hodgson, Melanie A. Carless, Hemant Kulkarni, Joanne E. Curran, Emma Sprooten, Emma E. Knowles, Samuel Mathias, Harald H.H. Göring, Nailin Yao, Rene L. Olvera, Peter T. Fox, Laura Almasy, Ravi Duggirala, John Blangero, David C. Glahn   +14 more
openaire   +3 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Decreased but persistent epigenetic age acceleration is associated with changes in T-cell subsets after initiation of highly active antiretroviral therapy in persons living with HIV

Frontiers in Bioinformatics
IntroductionPersons living with HIV (PLWH) experience the early onset of age-related illnesses, even in the setting of successful human immunodeficiency virus (HIV) suppression with highly active antiretroviral therapy (HAART).
Mary E. Sehl, Mary E. Sehl, Elizabeth Crabb Breen, Roger Shih, Fengxue Li, Joshua Zhang, Peter Langfelder, Peter Langfelder, Steve Horvath, Steve Horvath, Steve Horvath, Jay H. Bream, Priya Duggal, Jeremy Martinson, Steven M. Wolinsky, Otoniel Martinez-Maza, Christina M. Ramirez, Beth D. Jamieson   +17 more
doaj   +1 more source

DNA hydroxymethylation levels are altered in blood cells from Down syndrome persons enrolled in the MARK-AGE project [PDF]

, 2017
Down syndrome (DS) is caused by the presence of part or an entire extra copy of chromosome 21, a phenomenon that can cause a wide spectrum of clinically defined phenotypes of the disease. Most of the clinical signs of DS are typical of the ageing process
BACALINI, MARIA GIULIA, Breusing, Nicolle, Bürkle, Alexander, CAIAFA, Paola, CALABRESE, ROBERTA, Capri, Miriam, CICCARONE, FABIO, Franceschi, Claudio, Grune, Tilman, GUASTAFIERRO, Tiziana, Malavolta, Marco, Moreno villanueva, María, REALE, Anna, VALENTINI, ELISABETTA, ZAMPIERI, Michele   +14 more
core   +1 more source