Results 71 to 80 of about 5,571,062 (272)

Relationship Between Neighborhood Deprivation and Epigenetic Age Acceleration with Pain in Adults with Musculoskeletal Pain

, 2022
Residents of high-deprivation neighborhoods shoulder a greater burden of age-related health conditions, including experiencing worse chronic musculoskeletal pain outcomes, compared to residents of more affluent neighborhoods.
Jackson, Pamela
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Association of Epigenetic Age and Outcome in Critically Ill Patients

Critical Care Explorations
OBJECTIVES:. DNA methylation can be used to determine an individual’s biological age, as opposed to chronological age, an indicator of underlying health status.
Archana Sharma-Oates, PhD, Jack Sullivan, PhD, Daniel Pestana, MSc, Claudia C. dos Santos, MD, Alexandra Binnie, MD, Janet M. Lord, PhD   +5 more
doaj   +1 more source

Maternal plasma fatty acid patterns in mid-pregnancy and offspring epigenetic gestational age at birth

Epigenetics, 2022
Maternal pregnancy fatty acid status is associated with child health. Epigenetic gestational age acceleration, referring to a discrepancy between chronological and epigenetic gestational age, may underlie these associations.
Giulietta S. Monasso, Trudy Voortman, Janine F. Felix   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Ecological Realism Accelerates Epigenetic Aging in Mice

Aging Cell
ABSTRACT The aging of mammalian epigenomes fundamentally alters cellular functions, and such changes are the focus of many healthspan and lifespan studies. However, studies of this process typically use mouse models living under standardized laboratory conditions and neglect the impact of variation in social, physical, microbial, and ...
Matthew N. Zipple, Ivan Zhao, Daniel Chang Kuo, Sol Moe Lee, Michael J. Sheehan, Wanding Zhou   +5 more
openaire   +2 more sources

Lifetime stress accelerates epigenetic aging

European Psychiatry, 2015
Background Psychological stress is associated with accelerated cellular aging and increased risk for aging-related diseases, but the underlying molecular mechanisms are unclear. Methods We examined the effect of stress on a DNA methylation age predictor that was shown to correlate strongly with chronological age across human tissues (Horvath 2013).
Zannas, A., Carrillo-Roa, T., Iurato, S., Arloth, J., Roeh, S., Ressler, K., Nemeroff, C., Smith, A., Bradley, B., Heim, C., Lange, J., Brueckl, T., Ising, M., Wray, N., Erhardt, A., Binder, E., Mehta, D.   +16 more
openaire   +4 more sources

Decreased but persistent epigenetic age acceleration is associated with changes in T-cell subsets after initiation of highly active antiretroviral therapy in persons living with HIV

Frontiers in Bioinformatics
IntroductionPersons living with HIV (PLWH) experience the early onset of age-related illnesses, even in the setting of successful human immunodeficiency virus (HIV) suppression with highly active antiretroviral therapy (HAART).
Mary E. Sehl, Mary E. Sehl, Elizabeth Crabb Breen, Roger Shih, Fengxue Li, Joshua Zhang, Peter Langfelder, Peter Langfelder, Steve Horvath, Steve Horvath, Steve Horvath, Jay H. Bream, Priya Duggal, Jeremy Martinson, Steven M. Wolinsky, Otoniel Martinez-Maza, Christina M. Ramirez, Beth D. Jamieson   +17 more
doaj   +1 more source

Additional file 2 of Epigenetic age acceleration and cardiovascular outcomes in school-age children: The Generation R Study

, 2021
Additional file 2. Table S1. Maternal and child characteristics based on imputed data (n = 1115). Table S2. Non-response analysis. Table S3. Associations of gestational age acceleration by the epigenetic clock of Bohlin with cardiovascular outcomes in ...
Leanne K. Küpers (8609601), Vincent W. V. Jaddoe (7747976), Janine F. Felix (9351180), Giulietta S. Monasso (10726939)   +3 more
core   +1 more source