Results 51 to 60 of about 24,360 (295)

Clonal Hematopoiesis and Epigenetic Age Acceleration in Elderly Danish Twins [PDF]

HemaSphere, 2022
Clonal hematopoiesis of indeterminate potential (CHIP) is common in the elderly and has been reported to associate with accelerated epigenetic age (AgeAccel), especially intrinsic (ie, cell-type independent) AgeAccel and to a lesser degree extrinsic AgeAccel, which reflects the immune-cell composition of the peripheral blood.
Sørensen, Mette, Tulstrup, Morten, Hansen, Jakob Werner, Weischenfeldt, Joachim, Gronbaek, Kirsten, Christensen, Kaare   +5 more
openaire   +4 more sources

Metabolic and inflammatory biomarkers are associated with epigenetic aging acceleration estimates in the GOLDN study

Clinical Epigenetics, 2018
Background Recently, epigenetic age acceleration—or older epigenetic age in comparison to chronological age—has been robustly associated with mortality and various morbidities.
Marguerite R. Irvin, Stella Aslibekyan, Anh Do, Degui Zhi, Bertha Hidalgo, Steven A. Claas, Vinodh Srinivasasainagendra, Steve Horvath, Hemant K. Tiwari, Devin M. Absher, Donna K. Arnett   +10 more
doaj   +1 more source

Evo-devo of human adolescence: beyond disease models of early puberty [PDF]

, 2013
Despite substantial heritability in pubertal development, much variation remains to be explained, leaving room for the influence of environmental factors to adjust its phenotypic trajectory in the service of fitness goals.
A Templeton, AB Arquitt, AB Migliano, AK Pesonen, AS Parent, B Bogin, B Campbell, BH Smith, BJ Ellis, BJ Ellis, BJ Ellis, BJ Ellis, BS Zemel, C Ankarberg Lindgren, C Cooper, C Tardieu, CC Chen, CL Sisk, F Deng, GB Cutler Jr, GB Muller, GE Weisfeld, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Bowlby, J Bowlby, J James, J Tinggaard, Jay Belsky, JC Wingfield, JL Locke, JM Tither, KB Simondon, KK Ong, KK Ong, KO Klein, L Aksglaede, LA Proos, M Celio, M Del Giudice, M Krstevska-Konstantinova, M Mead, M Suzuki, ME Pembrey, MR Palmert, N Howell, NM Cameron, PD Gluckman, PD Kroboth, PJ Hunt, RG Westendorp, S White, SB Manuck, SC Stearns, W Arlt, W Copeland, WT Boyce, Z Hochberg, Z Hochberg, Z Hochberg, Z Hochberg, Z Hochberg, Ze'ev Hochberg   +69 more
core   +2 more sources

Epigenetic Age Acceleration and Cognitive Decline: A Twin Study

The Journals of Gerontology: Series A, 2021
AbstractBackgroundLittle is known about the role of DNA methylation (DNAm) epigenetic age acceleration in cognitive decline. Using a twin study design, we examined whether DNAm age acceleration is related to cognitive decline measured longitudinally in persons without a clinical diagnosis of dementia.MethodsWe studied 266 paired male twins (133 pairs ...
Viola Vaccarino, Minxuan Huang, Zeyuan Wang, Qin Hui, Amit J Shah, Jack Goldberg, Nicholas Smith, Belal Kaseer, Nancy Murrah, Oleksiy M Levantsevych, Lucy Shallenberger, Emily Driggers, J Douglas Bremner, Yan V Sun   +13 more
openaire   +3 more sources

Pre-reproductive parental enriching experiences influence progeny’s developmental trajectories [PDF]

, 2018
While the positive effects of environmental enrichment (EE) applied after weaning, in adulthood, during aging, or even in the presence of brain damage have been widely described, the transgenerational effects of pre-reproductive EE have been less ...
Berretta, Erica, Caporali, Paola, Cutuli, Debora, Gelfo, Francesca, Laricchiuta, Daniela, Petrosini, Laura   +5 more
core   +1 more source

Epigenetic age acceleration correlates with BMI in young adults

Aging, 2023
Obesity increases the risk of Type 2 diabetes, cardiovascular disease, several types of cancer, and other age-related disorders. Among older adults, obesity is also related to epigenetic age, typically measured with DNA methylation (DNAm). Because less is known about obesity and epigenetic aging earlier in the lifespan, this study examined the ...
Foster, Christy Anne, Barker-Kamps, Malcolm, Goering, Marlon, Patki, Amit, Tiwari, Hemant K., Mrug, Sylvie   +5 more
openaire   +2 more sources

Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis

JHEP Reports, 2020
Background & Aims: A DNA methylation (DNAm) signature derived from 353 CpG sites (the Horvath clock) has been proposed as an epigenetic measure of chronological and biological age.
Michael Trauner, Yevgeniy Gindin, Zhaoshi Jiang, Chuhan Chung, G. Mani Subramanian, Robert P. Myers, Aliya Gulamhusein, Kris V. Kowdley, Cynthia Levy, Zachary Goodman, Michael P. Manns, Andrew J. Muir, Christopher L. Bowlus   +12 more
doaj   +1 more source

Effect of metformin on the epigenetic age of peripheral blood in patients with diabetes mellitus

Frontiers in Genetics, 2022
Background: Metformin has been proven to have an antiaging effect. However, studies on how metformin affects global epigenetic regulation and its effect on the epigenetic clock in diabetes mellitus (DM) patients are limited.
Man Li, Litao Bao, Ping Zhu, Shuxia Wang
doaj   +1 more source

Can environmental conditions experienced in early life influence future generations? [PDF]

, 2014
The consequences of early developmental conditions for performance in later life are now subjected to convergent interest from many different biological sub-disciplines.
Burton, Tim, Metcalfe, Neil B.
core   +1 more source

Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization

Clinical Epigenetics, 2023
Background Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecular hallmarks such as epigenetic alterations and telomere attenuation reflect the biological process of aging. Epigenetic
Yosra Bejaoui, Fathima Humaira Amanullah, Mohamad Saad, Sara Taleb, Martina Bradic, Andre Megarbane, Ali Ait Hssain, Charbel Abi Khalil, Nady El Hajj   +8 more
doaj   +1 more source