Results 51 to 60 of about 5,571,062 (272)

Alcohol consumption and epigenetic age acceleration in young adults [PDF]

Aging, 2023
Alcohol is a widely consumed substance in the United States, however its effect on aging remains understudied. In this study of young adults, we examined whether cumulative alcohol consumption, i.e., alcohol years of beer, liquor, wine, and total alcohol, and recent binge drinking, were associated with four measures of age-related epigenetic changes ...
Nannini, Drew R, Joyce, Brian T, Zheng, Yinan, Gao, Tao, Wang, Jun, Liu, Lei, Jacobs, David R, Schreiner, Pamela J, Liu, Chunyu, Dai, Qi, Horvath, Steve, Lu, Ake T, Yaffe, Kristine, Greenland, Philip, Lloyd-Jones, Donald M, Hou, Lifang   +15 more
openaire   +4 more sources

Epigenetic age acceleration and cardiovascular outcomes in school-age children:The Generation R Study [PDF]

, 2021
Background: Hypertension and atherosclerosis may partly originate in early life. Altered epigenetic aging may be a mechanism underlying associations of early-life exposures and the development of cardiovascular risk factors in childhood.
Jaddoe, Vincent W.V., Küpers, Leanne K., Felix, Janine F., Monasso, Giulietta S.   +3 more
core   +1 more source

DNA methylation and the epigenetic clock in relation to physical frailty in older people: the Lothian Birth Cohort 1936

Clinical Epigenetics, 2018
Background The biological mechanisms underlying frailty in older people are poorly understood. There is some evidence to suggest that DNA methylation patterns may be altered in frail individuals.
Catharine R. Gale, Riccardo E. Marioni, Sarah E. Harris, John M. Starr, Ian J. Deary   +4 more
doaj   +1 more source

Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals [PDF]

Clinical Epigenetics, 2017
Human aging is associated with profound changes in one of the major epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like fashion, i.e., correlating with the calendar age of an individual, thus providing a new aging biomarker.
Nevalainen, Tapio, Kananen, Laura, Marttila, Saara, Jylhävä, Juulia, Nononen, Nina, Kähönen, Mika, Raitakari, Olli T, Hervonen, Antti, Jylhä, Marja, Lehtimäki, Terho, Hurme, Mikko   +10 more
openaire   +4 more sources

Metabolic and inflammatory biomarkers are associated with epigenetic aging acceleration estimates in the GOLDN study

Clinical Epigenetics, 2018
Background Recently, epigenetic age acceleration—or older epigenetic age in comparison to chronological age—has been robustly associated with mortality and various morbidities.
Marguerite R. Irvin, Stella Aslibekyan, Anh Do, Degui Zhi, Bertha Hidalgo, Steven A. Claas, Vinodh Srinivasasainagendra, Steve Horvath, Hemant K. Tiwari, Devin M. Absher, Donna K. Arnett   +10 more
doaj   +1 more source

An older subjective age is related to accelerated epigenetic aging.

Psychology and Aging, 2021
The present study examined the prospective association between subjective age and epigenetic clock in 2,253 adults (Mean age = 67.40, SD = 8.17) from the Health and Retirement Study. Subjective age and demographic factors were assessed in 2008/2010 and epigenetic clock was assessed in 2016 using the DNA methylation (DNAm) PhenoAge.
Yannick Stephan, Angelina R. Sutin, Martina Luchetti, Antonio Terracciano   +3 more
openaire   +2 more sources

Epigenetic Age Acceleration and Cognitive Decline: A Twin Study

The Journals of Gerontology: Series A, 2021
AbstractBackgroundLittle is known about the role of DNA methylation (DNAm) epigenetic age acceleration in cognitive decline. Using a twin study design, we examined whether DNAm age acceleration is related to cognitive decline measured longitudinally in persons without a clinical diagnosis of dementia.MethodsWe studied 266 paired male twins (133 pairs ...
Viola Vaccarino, Minxuan Huang, Zeyuan Wang, Qin Hui, Amit J Shah, Jack Goldberg, Nicholas Smith, Belal Kaseer, Nancy Murrah, Oleksiy M Levantsevych, Lucy Shallenberger, Emily Driggers, J Douglas Bremner, Yan V Sun   +13 more
openaire   +3 more sources

Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis

JHEP Reports, 2020
Background & Aims: A DNA methylation (DNAm) signature derived from 353 CpG sites (the Horvath clock) has been proposed as an epigenetic measure of chronological and biological age.
Michael Trauner, Yevgeniy Gindin, Zhaoshi Jiang, Chuhan Chung, G. Mani Subramanian, Robert P. Myers, Aliya Gulamhusein, Kris V. Kowdley, Cynthia Levy, Zachary Goodman, Michael P. Manns, Andrew J. Muir, Christopher L. Bowlus   +12 more
doaj   +1 more source

Epigenetic Age Acceleration and Psychiatric Disorders: A Systematic Review

, 2021
A systematic review on studies that have compared epigenetic age acceleration between participants grouped by a particular psychiatric disorder compared to an unaffected (or control ...
Samuel Antoniades, Sarah Cohen-Woods, David Balfour   +2 more
core   +1 more source

Effect of metformin on the epigenetic age of peripheral blood in patients with diabetes mellitus

Frontiers in Genetics, 2022
Background: Metformin has been proven to have an antiaging effect. However, studies on how metformin affects global epigenetic regulation and its effect on the epigenetic clock in diabetes mellitus (DM) patients are limited.
Man Li, Litao Bao, Ping Zhu, Shuxia Wang
doaj   +1 more source