Results 41 to 50 of about 24,360 (295)

Methylation age acceleration does not predict mortality in schizophrenia. [PDF]

, 2019
Schizophrenia (SCZ) is associated with high mortality. DNA methylation levels vary over the life course, and pre-selected combinations of methylation array probes can be used to estimate "methylation age" (mAge). mAge correlates highly with chronological
Burrage, Joe, Hannon, Eilis, Kowalec, Kaarina, Mansell, Georgina, Mill, Jonathan, Ophoff, Roel A, Ori, Anil PS, Sullivan, Patrick F   +7 more
core   +1 more source

Prenatal and early life influences on epigenetic age in children:a study of mother-offspring pairs from two cohort studies [PDF]

, 2015
DNA methylation-based biomarkers of aging are highly correlated with actual age. Departures of methylation-estimated age from actual age can be used to define epigenetic measures of child development or age acceleration (AA) in adults.
Gaunt, Tom R, Hemani, Gibran, Horvath, Steve, Kunze, Sonja, Lyttleton, Oliver, McArdle, Wendy L, Nohr, Ellen A, Peters, Annette, Relton, Caroline L, Ring, Susan M, Sharp, Gemma C, Simpkin, Andrew J, Smith, George Davey, Sorensen, Thorkild, Suderman, Matthew, Tilling, Kate, Waldenberger, Melanie, Ward-Caviness, Cavin   +17 more
core   +5 more sources

Lifetime Stress Accelerates Epigenetic Aging

European Psychiatry, 2015
Background Psychological stress is associated with accelerated cellular aging and increased risk for aging-related diseases, but the underlying molecular mechanisms are unclear. Methods We examined the effect of stress on a DNA methylation age predictor that was shown to correlate strongly with chronological age across human tissues (Horvath 2013).
A. Zannas, T. Carrillo-Roa, S. Iurato, K. Ressler, C. Nemeroff, A. Smith, J. Lange, B. Bradley, C. Heim, T. Brückl, M. Ising, N. Wray, A. Erhardt, E. Binder, D. Mehta   +14 more
openaire   +1 more source

Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration

Epigenetics, 2023
Early life is seen as a particularly sensitive period for environmental exposures. Natural space exposure during pregnancy has been associated with offspring health.
Irene Marques, Susana Santos, Giulietta S. Monasso, Serena Fossati, Martine Vrijheid, Mark Nieuwenhuijsen, Vincent W. V. Jaddoe, Janine F. Felix   +7 more
doaj   +1 more source

DNA repair‐deficient premature aging models display accelerated epigenetic age

Aging Cell, 2023
Abstract Several premature aging mouse models have been developed to study aging and identify interventions that can delay age‐related diseases. Yet, it is still unclear whether these models truly recapitulate natural aging.
Kevin Perez, Alberto Parras, Sara Picó, Cheyenne Rechsteiner, Amin Haghani, Robert Brooke, Calida Mrabti, Lucas Schoenfeldt, Steve Horvath, Alejandro Ocampo   +9 more
openaire   +3 more sources

Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study [PDF]

, 2016
Aging is associated with alterations in the content and patterns of DNA methylation virtually throughout the entire human lifespan. Reasons for these variations are not well understood.
Bacalini, MARIA GIULIA, Bernhardt, Jürgen, Breusing, Nicolle, Bürkle, Alexander, Caiafa, Paola, Calabrese, Roberta, Capri, Miriam, Ciccarone, Fabio, Dollé, Martijn, Franceschi, Claudio, Gonos, Efstathios S, Grubeck Loebenstein, Beatrix, Grune, Tilman, Guastafierro, Tiziana, Hervonen, Antti, Hurme, Mikko, Jansen, Eugène, Koller, Bernhard, Malavolta, Marco, Moreno Villanueva, María, Reale, Anna, Schӧn, Christiane, Sikora, Ewa, Sindlinger, Thilo, Slagboom, P. Eline, Toussaint, Olivier, Zampieri, Michele   +26 more
core   +2 more sources

Letter to the Editor:Moving science forward by increasing awareness of reporting and citation biases: a reply to Vrshek-Schallhorn et al. (2016) [PDF]

, 2016
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Bastiaansen, J A, de Vries, Y A, Franzen, M, Munafò, M R, Roest, A M   +4 more
core   +5 more sources

DNA methylation and the epigenetic clock in relation to physical frailty in older people: the Lothian Birth Cohort 1936

Clinical Epigenetics, 2018
Background The biological mechanisms underlying frailty in older people are poorly understood. There is some evidence to suggest that DNA methylation patterns may be altered in frail individuals.
Catharine R. Gale, Riccardo E. Marioni, Sarah E. Harris, John M. Starr, Ian J. Deary   +4 more
doaj   +1 more source

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]

, 2018
DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola, Ciccarone, Fabio, Tagliatesta, Stefano, Zampieri, Michele   +3 more
core   +1 more source

Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms [PDF]

, 2018
BACKGROUND: Premature aging and related diseases have been documented in HIV-infected adults. Data are now emerging also regarding accelerated aging process in HIV-infected children. METHODS: A narrative review was performed searching studies on PubMed
Bianconi, Martina, Chiappini, Elena, Dalzini, Annalisa, De Rossi, Anita, Galli, Luisa, Giaquinto, Carlo, Petrara, Maria Raffaella   +6 more
core   +1 more source