Results 41 to 50 of about 5,571,062 (272)

Obesity accelerates epigenetic aging of human liver [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Because obese people are at an increased risk of many age-related diseases, it is a plausible hypothesis that obesity increases the biological age of some tissues and cell types. However, it has been difficult to detect such an accelerated aging effect because it is unclear how to measure tissue age.
Horvath, Steve, Erhart, Wiebke, Brosch, Mario, Ammerpohl, Ole, von Schönfels, Witigo, Ahrens, Markus, Heits, Nils, Bell, Jordana T, Tsai, Pei-Chien, Spector, Tim D, Deloukas, Panos, Siebert, Reiner, Sipos, Bence, Becker, Thomas, Röcken, Christoph, Schafmayer, Clemens, Hampe, Jochen   +16 more
openaire   +3 more sources

The early-life exposome and epigenetic age acceleration in children [PDF]

, 2021
The early-life exposome influences future health and accelerated biological aging has been proposed as one of the underlying biological mechanisms. We investigated the association between more than 100 exposures assessed during pregnancy and in childhood
Haug, Line Småstuen, Bustamante Pineda, Mariona, Mark J. Nieuwenhuijsen, Vives-Usano, M, Nieuwenhuijsen, Mark J., Bustamante, Mariona, Andrusaityte, S, Léa Maitre, Dadvand, P, Keun, HC, Maribel Casas, Slama, R, Carracedo, Ángel, Sunyer, J, Haug, LS, Ruiz Arenas, Carlos, 1990-, Rémy Slama, Hernandez-Ferrer, Carles, Nieuwenhuijsen, Mark, J, Pelegrí, Dolors, de Prado-Bert, Paula, McEachan, Rosie, Martine Vrijheid, Casas, M, Chatzi, L, Nieuwenhuijsen, MJ, Juan R. González, Andrusaityte, Sandra, Lepeule, Johanna, Haug, Line, S, Sunyer Deu, Jordi, González, Juan R., Ángel Carracedo, Haug, Line S., González, Juan Ramón, Robinson, O, Mariona Bustamante, Bustamante, M, Vives Usano, Marta, 1990-, Paula de Prado-Bert, Dolors Pelegrí, Sandra Andrusaityte, Oliver Robinson, Grazuleviciene, R, Cadiou, S, Payam Dadvand, Kristine B. Gutzkow, Ruiz-Arenas, C, Carracedo, Á, Pelegrí, D, Chatzi, Leda, Marta Vives-Usano, Vrijheid, M, Casas, Maribel, Keun, Hector, C, Maitre, Léa, González, Juan, R, Hernandez-Ferrer, C, Rosie McEachan, Vrijheid, Martine, Solène Cadiou, Johanna Lepeule, Nieuwenhuijsen, Mark, Gutzkow, Kristine, B, Carlos Ruiz-Arenas, Gutzkow, Kristine B., Lepeule, J, Gutzkow, KB, Hector C. Keun, Leda Chatzi, Prado Bert, Paula de, Carracedo Álvarez, Ángel, Gützkow, Kristine Bjerve, Vafeiadi, Marina, Jordi, Sunyer, Line S. Haug, McEachan, R, Sunyer, Jordi, Ruiz-Arenas, Carlos, de Prado-Bert, P, Dadvand, Payam, Robinson, Oliver, Keun, Hector C., Carles Hernandez-Ferrer, Jordi Sunyer, González, JR, Maitre, L, Vafeiadi, M, Grazuleviciene, Regina, Regina Grazuleviciene, Vives-Usano, Marta, Marina Vafeiadi, Cadiou, Soléne, Slama, Rémy   +93 more
core   +1 more source

Cumulative stress, PTSD, and emotion dysregulation during pregnancy and epigenetic age acceleration in Hispanic mothers and their newborn infants

Epigenetics, 2023
Pregnancy can exacerbate or prompt the onset of stress-related disorders, such as post-traumatic stress disorder (PTSD). PTSD is associated with heightened stress responsivity and emotional dysregulation, as well as increased risk of chronic disorders ...
Seyma Katrinli, Alicia K Smith, Stacy S. Drury, Jonathan Covault, Julian D. Ford, Vijender Singh, Bo Reese, Amy Johnson, Victoria Scranton, Pamela Fall, Margaret Briggs-Gowan, Damion J Grasso   +11 more
doaj   +1 more source

Cytomegalovirus infection accelerates epigenetic aging

Experimental Gerontology, 2015
Epigenetic mechanisms such as DNA methylation (DNAm) have a central role in the regulation of gene expression and thereby in cellular differentiation and tissue homeostasis. It has recently been shown that aging is associated with profound changes in DNAm. Several of these methylation changes take place in a clock-like fashion, i.e.
Jylhava Juulia, Kananen Laura, Jylha Marja, Marttila Saara, Nevalainen Tapio, Hervonen Antti, Hurme Mikko, Hurme Mikko   +7 more
openaire   +2 more sources

Epigenetic clock analysis of blood samples in drug-naive first-episode schizophrenia patients

BMC Psychiatry, 2023
Background Schizophrenia (SCZ) is a severe and chronic psychiatric disorder with premature age-related physiological changes. However, numerous previous studies examined the epigenetic age acceleration in SCZ patients and yielded inconclusive results. In
Zongchang Li, Xiaofen Zong, David Li, Ying He, Jinsong Tang, Maolin Hu, Xiaogang Chen   +6 more
doaj   +1 more source

Work-related stress and well-being in association with epigenetic age acceleration: a Northern Finland Birth Cohort 1966 Study [PDF]

, 2022
Recent evidence indicates consistent association of low socioeconomic status with epigenetic age acceleration, measured from DNA methylation. As work characteristics and job stressors are crucial components of socioeconomic status, we investigated their ...
Vineis, Paolo, Ala-Mursula, Leena, Järvelin, M.-R. (Marjo-Riitta), Virtanen, Marianna, Virtanen, M. (Marianna), Fiorito, G. (Giovanni), Robinson, O. (Oliver), Ronkainen, J, D’Errico, Angelo, Freni-Sterrantino, A, Fiorito, Giovanni, Ronkainen, J. (Justiina), Freni-Sterrantino, Anna, D'Errico, A, Vineis, P. (Paolo), Freni Sterrantino, Anna, Ala-Mursula, L, Fiorito, G, Oliver, Robinson, Järvelin, Marjo-Riitta, Jarvelin, M-R, Robinson, Oliver, Freni-Sterrantino, A. (Anna), D'errico, Angelo, Ronkainen, Justiina, Robinson, O, Virtanen, M,, Ala-Mursula, L. (Leena), Vineis, P, D’Errico, A. (Angelo), Jarvelin, Marjo Riitta   +30 more
core   +1 more source

Epigenetic clocks derived from western samples differentially reflect Taiwanese health outcomes

Frontiers in Genetics, 2023
Introduction: Several epigenetic clocks have been developed, with five measures of epigenetic age acceleration (EAA) especially receiving extensive investigations: HannumEAA, IEAA, PhenoEAA, GrimEAA, and DunedinPACE.
Wan-Yu Lin, Wan-Yu Lin, Wan-Yu Lin
doaj   +1 more source

Associations between prenatal phthalate exposure and childhood epigenetic age acceleration [PDF]

, 2023
BACKGROUND: Phthalates, a group of pervasive endocrine-disrupting chemicals found in plastics and personal care products, have been associated with a wide range of developmental and health outcomes.
Nina Holland, Holland, Nina, Julianna Deardorff, Khodasevich, Dennis, Alan Hubbard, Deardorff, Julianna, Eskenazi, Brenda, Andres Cardenas, Cardenas, Andres, Hubbard, Alan, Dennis Khodasevich, Kim Harley, Brenda Eskenazi, Harley, Kim   +13 more
core   +1 more source

Epigenetic Age Acceleration [PDF]

Circulation: Genomic and Precision Medicine, 2018
See Article by Roetker et al Epigenetic age seems like a concept pulled from a futuristic science-fiction movie where a drop of blood is fed into a machine, in which an algorithm churns through an accumulation of chemical groups coating a strand of DNA and spits out an individual’s true age reflecting a lifetime of experiences and exposures ...
openaire   +2 more sources

Short Sleep and Insomnia Are Associated With Accelerated Epigenetic Age

Psychosomatic Medicine, 2022
ABSTRACT Objective Short sleep and insomnia are each associated with a greater risk of age-related disease, which suggests that insufficient sleep may accelerate biological aging. We examine whether short sleep and insomnia alone or together relates to epigenetic age among older adults.
Cynthia D.J. Kusters, Eric T. Klopack, Eileen M. Crimmins, Teresa E. Seeman, Steve Cole, Judith E. Carroll   +5 more
openaire   +2 more sources